STAU2

STAU2
Identifikatori
Aliasi	STAU2
Vanjski ID-jevi	OMIM: 605920 MGI: 1352508 HomoloGene: 8666 GeneCards: STAU2
Lokacija gena (čovjek)
Hrom.	Hromosom 8 (čovjek)
Kraj	73,747,708 bp
Lokacija gena (miš)
Hrom.	Hromosom 1 (miš)
Kraj	16,590,336 bp
Obrazac RNK ekspresije
	Više referentnih podataka o ekspresiji
Ontologija gena
Molekularna funkcija	• double-stranded RNA binding; • GO:0001948, GO:0016582 vezivanje za proteine; • vezivanje sa RNK;
Ćelijska komponenta	• citoplazma; • Mikrotubula; • Jedarce; • Endoplazmatski retikulum; • membrana; • jedro;
Biološki proces	• GO:0015915 transport;
	Izvori:Amigo / QuickGO
Ortolozi
	27067
	29819
	ENSG00000040341
	ENSMUSG00000025920
	Q9NUL3
	Q8CJ67
NM_014393; NM_001164380; NM_001164381; NM_001164382; NM_001164383;
	NM_001164384; NM_001164385
	NM_001111272; NM_025303; NM_001347044; NM_001347045
NP_001157852; NP_001157853; NP_001157854; NP_001157855; NP_001157856;
	NP_001157857; NP_055208
	NP_001104742; NP_001333973; NP_001333974; NP_079579
	Wikipodaci
Pogledaj/uredi – čovjek	Pogledaj/uredi – miš

Staufenski homolog 2 dvolančano RNK-vezujućeg proteina je protein koji je kod ljudi kodiran genom STAU2.^[5]^[6]

Aminokiselinska sekvenca

Dužina polipeptidnog lanca je 570 aminokiselina, а molekulska težina 62.641 Da.^[7]

C: Cistein

D: Asparaginska kiselina

E: Glutaminska kiselina

F: Fenilalanin

G: Glicin

H: Histidin

I: Izoleucin

K: Lizin

L: Leucin

M: Metionin

N: Asparagin

P: Prolin

Q: Glutamin

R: Arginin

S: Serin

T: Treonin

V: Valin

W: Triptofan

Y: Tirozin

10	20	30	40	50
MANPKEKTAM	CLVNELARFN	RVQPQYKLLN	ERGPAHSKMF	SVQLSLGEQT
WESEGSSIKK	AQQAVANKAL	TESTLPKPVQ	KPPKSNVNNN	PGSITPTVEL
NGLAMKRGEP	AIYRPLDPKP	FPNYRANYNF	RGMYNQRYHC	PVPKIFYVQL
TVGNNEFFGE	GKTRQAARHN	AAMKALQALQ	NEPIPERSPQ	NGESGKDMDD
DKDANKSEIS	LVFEIALKRN	MPVSFEVIKE	SGPPHMKSFV	TRVSVGEFSA
EGEGNSKKLS	KKRAATTVLQ	ELKKLPPLPV	VEKPKLFFKK	RPKTIVKAGP
EYGQGMNPIS	RLAQIQQAKK	EKEPDYVLLS	ERGMPRRREF	VMQVKVGNEV
ATGTGPNKKI	AKKNAAEAML	LQLGYKASTN	LQDQLEKTGE	NKGWSGPKPG
FPEPTNNTPK	GILHLSPDVY	QEMEASRHKV	ISGTTLGYLS	PKDMNQPSSS
FFSISPTSNS	SATIARELLM	NGTSSTAEAI	GLKGSSPTPP	CSPVQPSKQL
EYLARIQGFQ	AALSALKQFS	EQGLDPIDGA	MNIEKGSLEK	QAKHLREKAD
NNQAPPGSIA	QDCKKSNSAV

Funkcija

Staufen homolog 2 je član porodice proteina koji se vezuju za dvolančanu RNK (dsRNK), uključeni u transport i/ili lokalizaciju iRNK u različite podćelijske odjele i/ili organele. Ove proteine karakterizira prisutnost više dsRNK-vezujućih domena, koji su potrebni za vezanje RNK sa dvolančanom sekundarnom strukturom. Staufenski homolog 2 ima 48,5% i 59,9% sličnosti sa staufenom kod Drosophila i ljudi. Tačna funkcija staufen homologa 2 nije poznata, ali budući da sadrži tri kopije konzerviranog domena vezanja dsRNK, mogla bi biti uključena u događaje vezanja za dvolančane RNK.^[6]

Reference

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000040341 - Ensembl, maj 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000025920 - Ensembl, maj 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Buchner G, Bassi MT, Andolfi G, Ballabio A, Franco B (novembar 1999). "Identification of a novel homolog of the Drosophila staufen protein in the chromosome 8q13-q21.1 region". Genomics. 62 (1): 113–8. doi:10.1006/geno.1999.6015. PMID 10585778.
^ ^a ^b "Entrez Gene: STAU2 staufen, RNA binding protein, homolog 2 (Drosophila)".
^ "UniProt, Q9NUL3" (jezik: engleski). Pristupljeno 21. 9. 2021.

Dopunska literatura

Kiebler MA, DesGroseillers L (januar 2000). "Molecular insights into mRNA transport and local translation in the mammalian nervous system". Neuron. 25 (1): 19–28. doi:10.1016/S0896-6273(00)80868-5. PMID 10707969. S2CID 2565210.
Furic L, Maher-Laporte M, DesGroseillers L (februar 2008). "A genome-wide approach identifies distinct but overlapping subsets of cellular mRNAs associated with Staufen1- and Staufen2-containing ribonucleoprotein complexes". RNA. 14 (2): 324–35. doi:10.1261/rna.720308. PMC 2212254. PMID 18094122.
Beausoleil SA, Villén J, Gerber SA, Rush J, Gygi SP (oktobar 2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nature Biotechnology. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID 16964243. S2CID 14294292.
Chatel-Chaix L, Clément JF, Martel C, Bériault V, Gatignol A, DesGroseillers L, Mouland AJ (april 2004). "Identification of Staufen in the human immunodeficiency virus type 1 Gag ribonucleoprotein complex and a role in generating infectious viral particles". Molecular and Cellular Biology. 24 (7): 2637–48. doi:10.1128/MCB.24.7.2637-2648.2004. PMC 371130. PMID 15024055.
Duchaîne TF, Hemraj I, Furic L, Deitinghoff A, Kiebler MA, DesGroseillers L (august 2002). "Staufen2 isoforms localize to the somatodendritic domain of neurons and interact with different organelles". Journal of Cell Science. 115 (Pt 16): 3285–95. PMID 12140260.

Vanjski linkovi

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000040341 - Ensembl, maj 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000025920 - Ensembl, maj 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10585778-5] Buchner G, Bassi MT, Andolfi G, Ballabio A, Franco B (novembar 1999). "Identification of a novel homolog of the Drosophila staufen protein in the chromosome 8q13-q21.1 region". Genomics. 62 (1): 113–8. doi:10.1006/geno.1999.6015. PMID 10585778.

[entrez-6] "Entrez Gene: STAU2 staufen, RNA binding protein, homolog 2 (Drosophila)".

[UniProt-7] "UniProt, Q9NUL3" (jezik: engleski). Pristupljeno 21. 9. 2021.

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