ST6GALNAC6

ST6GALNAC6
Identifikatori
Aliasi	ST6GALNAC6
Vanjski ID-jevi	OMIM: 610135 MGI: 1355316 HomoloGene: 8390 GeneCards: ST6GALNAC6
Lokacija gena (čovjek)
Hrom.	Hromosom 9 (čovjek)
Kraj	127,905,408 bp
Lokacija gena (miš)
Hrom.	Hromosom 2 (miš)
Kraj	32,510,818 bp
Ontologija gena
Molekularna funkcija	• aktivnost sa transferazom; • glycosyltransferase activity; • sialyltransferase activity; • alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity;
Ćelijska komponenta	• integral component of membrane; • Golđijev aparat; • membrana; • ćelijska membrana; • Golđijeva membrana; • citoplazma;
Biološki proces	• cell-cell recognition; • glycoprotein metabolic process; • glycosphingolipid metabolic process; • GO:0033578, GO:0033577, GO:0033575, GO:0033576 protein glycosylation; • glycosylceramide metabolic process; • oligosaccharide metabolic process; • sialylation; • protein N-linked glycosylation via asparagine; • ganglioside biosynthetic process; • oligosaccharide biosynthetic process;
	Izvori:Amigo / QuickGO
Ortolozi
	30815
	50935
	ENSG00000160408
	ENSMUSG00000026811
	Q969X2
	Q9JM95
NM_001286999; NM_001287000; NM_001287001; NM_001287002; NM_001287003;
	NM_013443; NM_001388489
NM_001025310; NM_001025311; NM_001289547; NM_001289548; NM_001289549;
	NM_016973
NP_001273928; NP_001273929; NP_001273930; NP_001273931; NP_001273932;
	NP_038471
NP_001020481; NP_001020482; NP_001276476; NP_001276477; NP_001276478;
	NP_058669
	Wikipodaci
Pogledaj/uredi – čovjek	Pogledaj/uredi – miš

Alfa-N-acetilgalaktozaminid alfa-2,6-sijaliltransferaza 6 je enzim koji je kod ljudi kodiran genom ST6GALNAC6.^[5]^[6]

Aminokiselinska sekvenca

Dužina polipeptidnog lanca je 333 aminokiseline, а molekulska težina 38.068 Da.^[7]

C: Cistein

D: Asparaginska kiselina

E: Glutaminska kiselina

F: Fenilalanin

G: Glicin

H: Histidin

I: Izoleucin

K: Lizin

L: Leucin

M: Metionin

N: Asparagin

P: Prolin

Q: Glutamin

R: Arginin

S: Serin

T: Treonin

V: Valin

W: Triptofan

Y: Tirozin

10	20	30	40	50
MACSRPPSQC	EPTSLPPGPP	AGRRHLPLSR	RRREMSSNKE	QRSAVFVILF
ALITILILYS	SNSANEVFHY	GSLRGRSRRP	VNLKKWSITD	GYVPILGNKT
LPSRCHQCVI	VSSSSHLLGT	KLGPEIERAE	CTIRMNDAPT	TGYSADVGNK
TTYRVVAHSS	VFRVLRRPQE	FVNRTPETVF	IFWGPPSKMQ	KPQGSLVRVI
QRAGLVFPNM	EAYAVSPGRM	RQFDDLFRGE	TGKDREKSHS	WLSTGWFTMV
IAVELCDHVH	VYGMVPPNYC	SQRPRLQRMP	YHYYEPKGPD	ECVTYIQNEH
SRKGNHHRFI	TEKRVFSSWA	QLYGITFSHP	SWT

Reference

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000160408 - Ensembl, maj 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000026811 - Ensembl, maj 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Tsuchida A, Okajima T, Furukawa K, Ando T, Ishida H, Yoshida A, Nakamura Y, Kannagi R, Kiso M, Furukawa K (Jun 2003). "Synthesis of disialyl Lewis a (Le(a)) structure in colon cancer cell lines by a sialyltransferase, ST6GalNAc VI, responsible for the synthesis of alpha-series gangliosides". J Biol Chem. 278 (25): 22787–94. doi:10.1074/jbc.M211034200. PMID 12668675.
^ "Entrez Gene: ST6GALNAC6 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6".
^ "UniProt, Q969X2". Pristupljeno 12. 9. 2021.

Dopunska literatura

Senda M, Ito A, Tsuchida A, et al. (2007). "Identification and expression of a sialyltransferase responsible for the synthesis of disialylgalactosylgloboside in normal and malignant kidney cells: downregulation of ST6GalNAc VI in renal cancers". Biochem. J. 402 (3): 459–70. doi:10.1042/BJ20061118. PMC 1863573. PMID 17123352.
Lim J, Hao T, Shaw C, et al. (2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell. 125 (4): 801–14. doi:10.1016/j.cell.2006.03.032. PMID 16713569. S2CID 13709685.
Harduin-Lepers A, Mollicone R, Delannoy P, Oriol R (2005). "The animal sialyltransferases and sialyltransferase-related genes: a phylogenetic approach". Glycobiology. 15 (8): 805–17. doi:10.1093/glycob/cwi063. PMID 15843597.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Clark HF, Gurney AL, Abaya E, et al. (2003). "The Secreted Protein Discovery Initiative (SPDI), a Large-Scale Effort to Identify Novel Human Secreted and Transmembrane Proteins: A Bioinformatics Assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Okajima T, Chen HH, Ito H, et al. (2000). "Molecular cloning and expression of mouse GD1alpha/GT1aalpha/GQ1balpha synthase (ST6GalNAc VI) gene". J. Biol. Chem. 275 (10): 6717–23. doi:10.1074/jbc.275.10.6717. PMID 10702226.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000160408 - Ensembl, maj 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000026811 - Ensembl, maj 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid12668675-5] Tsuchida A, Okajima T, Furukawa K, Ando T, Ishida H, Yoshida A, Nakamura Y, Kannagi R, Kiso M, Furukawa K (Jun 2003). "Synthesis of disialyl Lewis a (Le(a)) structure in colon cancer cell lines by a sialyltransferase, ST6GalNAc VI, responsible for the synthesis of alpha-series gangliosides". J Biol Chem. 278 (25): 22787–94. doi:10.1074/jbc.M211034200. PMID 12668675.

[entrez-6] "Entrez Gene: ST6GALNAC6 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6".

[UniProt-7] "UniProt, Q969X2". Pristupljeno 12. 9. 2021.

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