SSR1

Podjedinica alfa translokonu pridruženog proteina jest protein koji je kod ljudi kodiran genom SSR1.

SSR1
Identifikatori
Aliasi	SSR1
Vanjski ID-jevi	OMIM: 600868 MGI: 105082 HomoloGene: 2368 GeneCards: SSR1
Lokacija gena (čovjek) Hrom. Hromosom 6 (čovjek) Bend 6p24.3 Početak 7,268,306 bp Kraj 7,347,446 bp
Lokacija gena (miš) Hrom. Hromosom 13 (miš) Bend 13|13 A3.3 Početak 38,150,581 bp Kraj 38,178,193 bp
Obrazac RNK ekspresije Više referentnih podataka o ekspresiji
Ontologija gena Molekularna funkcija • GO:0001948, GO:0016582 vezivanje za proteine Ćelijska komponenta • integral component of membrane • endoplasmic reticulum membrane • membrana • Endoplazmatski retikulum Biološki proces • IRE1-mediated unfolded protein response • cotranslational protein targeting to membrane • positive regulation of cell population proliferation Izvori:Amigo / QuickGO
Ortolozi
Vrste	Čovjek	Miš
Entrez	6745	107513
Ensembl	ENSG00000124783	ENSMUSG00000021427
UniProt	P43307	Q9CY50
RefSeq (mRNK)	NM_001292008 NM_003144	NM_025965 NM_001360842
RefSeq (bjelančevina)	NP_001278937 NP_003135	NP_080241 NP_001347771
Lokacija (UCSC)	Chr 6: 7.27 – 7.35 Mb	Chr 13: 38.15 – 38.18 Mb
PubMed pretraga
Wikipodaci
Pogledaj/uredi – čovjek Pogledaj/uredi – miš

Aminokiselinska sekvenca

Dužina polipeptidnog lanca je 286 aminokiselina, а molekulska težina 32.235 Da.

• C: Cistein
• D: Asparaginska kiselina
• E: Glutaminska kiselina
• F: Fenilalanin
• G: Glicin
• H: Histidin
• I: Izoleucin
• K: Lizin
• L: Leucin
• M: Metionin
• N: Asparagin
• P: Prolin
• Q: Glutamin
• R: Arginin
• S: Serin
• T: Treonin
• V: Valin
• W: Triptofan
• Y: Tirozin

10		20		30		40		50
MRLLPRLLLL		LLLVFPATVL		FRGGPRGLLA		VAQDLTEDEE		TVEDSIIEDE
DDEAEVEEDE		PTDLVEDKEE		EDVSGEPEAS		PSADTTILFV		KGEDFPANNI
VKFLVGFTNK		GTEDFIVESL		DASFRYPQDY		QFYIQNFTAL		PLNTVVPPQR
QATFEYSFIP		AEPMGGRPFG		LVINLNYKDL		NGNVFQDAVF		NQTVTVIERE
DGLDGETIFM		YMFLAGLGLL		VIVGLHQLLE		SRKRKRPIQK		VEMGTSSQND
VDMSWIPQET		LNQINKASPR		RLPRKRAQKR		SVGSDE

Funkcija

Receptor signalne sekvence (SSR) je glikozilirani endoplazmatski retikulum (ER), membranski receptor povezan s translokacijom proteina preko membrane ER. SSR se sastoji od dvije podjedinice, 34-kD glikoproteina kodiranog ovim genom i 22-kD-skog glikoproteina. Ovaj gen stvara nekoliko tipova iRNK, kao rezultat složene alternativne poliadenilacije. Ovaj gen je neobičan po tome što koristi sekvence poliA signalnih sekvenci koje su isključivo nekanonske.

Dopunska literatura

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