SPATA5

SPATA5
Identifikatori
Aliasi	SPATA5
Vanjski ID-jevi	OMIM: 613940 MGI: 1927170 HomoloGene: 56920 GeneCards: SPATA5
Lokacija gena (čovjek)
Hrom.	Hromosom 4 (čovjek)
Kraj	123,319,433 bp
Lokacija gena (miš)
Hrom.	Hromosom 3 (miš)
Kraj	37,633,245 bp
Obrazac RNK ekspresije
	; ; ; ;
	Više referentnih podataka o ekspresiji
Ontologija gena
Molekularna funkcija	• nucleotide binding; • ATP binding; • ATPase activity; • hydrolase activity;
Ćelijska komponenta	• citoplazma; • mitohondrija;
Biološki proces	• multicellular organism development; • Ćelijska diferencijacija; • brain development; • Spermatogeneza;
	Izvori:Amigo / QuickGO
Ortolozi
	166378
	57815
	ENSG00000145375
	ENSMUSG00000027722
	Q8NB90
	Q3UMC0
	NM_145207; NM_001317799; NM_001345856
	NM_001163511; NM_021343; NM_001310473
	NP_001304728; NP_001332785; NP_660208
	NP_001156983; NP_001297402; NP_067318
	Wikipodaci
Pogledaj/uredi – čovjek	Pogledaj/uredi – miš

Spermatogenezno-pridruženi protein 5 jest protein koji je kod ljudi kodiran genom SPATA5 sa hromosoma 4.^[5]^[6]

Aminokiselinska sekvenca

Dužina polipeptidnog lanca je 893 aminokiseline, а molekulska težina 97.904 Da.^[7].

C: Cistein

D: Asparaginska kiselina

E: Glutaminska kiselina

F: Fenilalanin

G: Glicin

H: Histidin

I: Izoleucin

K: Lizin

L: Leucin

M: Metionin

N: Asparagin

P: Prolin

Q: Glutamin

R: Arginin

S: Serin

T: Treonin

V: Valin

W: Triptofan

Y: Tirozin

10	20	30	40	50
MSSKKNRKRL	NQSAENGSSL	PSAASSCAEA	RAPSAGSDFA	ATSGTLTVTN
LLEKVDDKIP	KTFQNSLIHL	GLNTMKSANI	CIGRPVLLTS	LNGKQEVYTA
WPMAGFPGGK	VGLSEMAQKN	VGVRPGDAIQ	VQPLVGAVLQ	AEEMDVALSD
KDMEINEEEL	TGCILRKLDG	KIVLPGNFLY	CTFYGRPYKL	QVLRVKGADG
MILGGPQSDS	DTDAQRMAFE	QSSMETSSLE	LSLQLSQLDL	EDTQIPTSRS
TPYKPIDDRI	TNKASDVLLD	VTQSPGDGSG	LMLEEVTGLK	CNFESAREGN
EQLTEEERLL	KFSIGAKCNT	DTFYFISSTT	RVNFTEIDKN	SKEQDNQFKV
TYDMIGGLSS	QLKAIREIIE	LPLKQPELFK	SYGIPAPRGV	LLYGPPGTGK
TMIARAVANE	VGAYVSVING	PEIISKFYGE	TEAKLRQIFA	EATLRHPSII
FIDELDALCP	KREGAQNEVE	KRVVASLLTL	MDGIGSEVSE	GQVLVLGATN
RPHALDAALR	RPGRFDKEIE	IGVPNAQDRL	DILQKLLRRV	PHLLTEAELL
QLANSAHGYV	GADLKVLCNE	AGLCALRRIL	KKQPNLPDVK	VAGLVKITLK
DFLQAMNDIR	PSAMREIAID	VPNVSWSDIG	GLESIKLKLE	QAVEWPLKHP
ESFIRMGIQP	PKGVLLYGPP	GCSKTMIAKA	LANESGLNFL	AIKGPELMNK
YVGESERAVR	ETFRKARAVA	PSIIFFDELD	ALAVERGSSL	GAGNVADRVL
AQLLTEMDGI	EQLKDVTILA	ATNRPDRIDK	ALMRPGRIDR	IIYVPLPDAA
TRREIFKLQF	HSMPVSNEVD	LDELILQTDA	YSGAEIVAVC	REAALLALEE
DIQANLIMKR	HFTQALSTVT	PRIPESLRRF	YEDYQEKSGL	HTL

Reference

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000145375 - Ensembl, maj 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000027722 - Ensembl, maj 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Katoh Y, Katoh M (Feb 2006). "FGF signaling inhibitor, SPRY4, is evolutionarily conserved target of WNT signaling pathway in progenitor cells". International Journal of Molecular Medicine. 17 (3): 529–32. doi:10.3892/ijmm.17.3.529. PMID 16465403.
^ "Entrez Gene: SPATA5 spermatogenesis associated 5".
^ "UniProt, Q8NB90" (jezik: engleski). Pristupljeno 31. 10. 2021.

Dopunska literatura

Liu Y, Black J, Kisiel N, Kulesz-Martin MF (2000). "SPAF, a new AAA-protein specific to early spermatogenesis and malignant conversion". Oncogene. 19 (12): 1579–88. doi:10.1038/sj.onc.1203442. PMID 10734318.
Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination". Genome Research. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Research. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
Simpson JC, Wellenreuther R, Poustka A, et al. (2001). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing". EMBO Reports. 1 (3): 287–92. doi:10.1093/embo-reports/kvd058. PMC 1083732. PMID 11256614.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proceedings of the National Academy of Sciences of the United States of America. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nature Genetics. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to biology: a functional genomics pipeline". Genome Research. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Research. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006". Nucleic Acids Research. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000145375 - Ensembl, maj 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000027722 - Ensembl, maj 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid16465403-5] Katoh Y, Katoh M (Feb 2006). "FGF signaling inhibitor, SPRY4, is evolutionarily conserved target of WNT signaling pathway in progenitor cells". International Journal of Molecular Medicine. 17 (3): 529–32. doi:10.3892/ijmm.17.3.529. PMID 16465403.

[entrez-6] "Entrez Gene: SPATA5 spermatogenesis associated 5".

[UniProt-7] "UniProt, Q8NB90" (jezik: engleski). Pristupljeno 31. 10. 2021.

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