Protein SMG7 jest protein koji je kod ljudi kodiran genom SMG7 sa hromosoma 1.[5][6][7][8]

SMG7
Dostupne strukture
PDBPretraga ortologa: PDBe RCSB
Spisak PDB ID kodova

1YA0

Identifikatori
AliasiSMG7
Vanjski ID-jeviOMIM: 610964 MGI: 2682334 HomoloGene: 32235 GeneCards: SMG7
Lokacija gena (čovjek)
Hromosom 1 (čovjek)
Hrom.Hromosom 1 (čovjek)[1]
Hromosom 1 (čovjek)
Genomska lokacija za SMG7
Genomska lokacija za SMG7
Bend1q25.3Početak183,472,216 bp[1]
Kraj183,598,246 bp[1]
Lokacija gena (miš)
Hromosom 1 (miš)
Hrom.Hromosom 1 (miš)[2]
Hromosom 1 (miš)
Genomska lokacija za SMG7
Genomska lokacija za SMG7
Bend1|1 G3Početak152,712,746 bp[2]
Kraj152,778,397 bp[2]
Obrazac RNK ekspresije




Više referentnih podataka o ekspresiji
Ontologija gena
Molekularna funkcija protein phosphatase 2A binding
GO:0001948, GO:0016582 vezivanje za proteine
telomeric DNA binding
ribonuclease activity
ribonucleoprotein complex binding
telomerase RNA binding
Ćelijska komponenta citoplazma
intermediate filament cytoskeleton
jedro
telomerase holoenzyme complex
citosol
Biološki proces regulation of dephosphorylation
Nonsens-posredovano propadanje iRNK
mRNA export from nucleus
telomere maintenance via telomerase
regulation of RNA stability
RNA phosphodiester bond hydrolysis
regulation of telomere maintenance via telomerase
Izvori:Amigo / QuickGO
Ortolozi
VrsteČovjekMiš
Entrez
Ensembl
UniProt
RefSeq (mRNK)
NM_001174061
NM_014837
NM_173156
NM_201568
NM_201569

NM_001331007
NM_001350219
NM_001350220
NM_001350221
NM_001350222
NM_001375584
NM_001375585

NM_001005507
NM_001160256
NM_001160257
NM_001359257

RefSeq (bjelančevina)
NP_001167532
NP_001317936
NP_775179
NP_963862
NP_963863

NP_001337148
NP_001337149
NP_001337150
NP_001337151
NP_001362513
NP_001362514

NP_001005507
NP_001153728
NP_001153729
NP_001346186

Lokacija (UCSC)Chr 1: 183.47 – 183.6 MbChr 1: 152.71 – 152.78 Mb
PubMed pretraga[3][4]
Wikipodaci
Pogledaj/uredi – čovjekPogledaj/uredi – miš

Aminokiselinska sekvenca

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Dužina polipeptidnog lanca je 1.137 aminokiselina, a molekulska 127.282 težina Da.[9]

1020304050
MSLQSAQYLRQAEVLKADMTDSKLGPAEVWTSRQALQDLYQKMLVTDLEY
ALDKKVEQDLWNHAFKNQITTLQGQAKNRANPNRSEVQANLSLFLEAASG
FYTQLLQELCTVFNVDLPCRVKSSQLGIISNKQTHTSAIVKPQSSSCSYI
CQHCLVHLGDIARYRNQTSQAESYYRHAAQLVPSNGQPYNQLAILASSKG
DHLTTIFYYCRSIAVKFPFPAASTNLQKALSKALESRDEVKTKWGVSDFI
KAFIKFHGHVYLSKSLEKLSPLREKLEEQFKRLLFQKAFNSQQLVHVTVI
NLFQLHHLRDFSNETEQHTYSQDEQLCWTQLLALFMSFLGILCKCPLQNE
SQEESYNAYPLPAVKVSMDWLRLRPRVFQEAVVDERQYIWPWLISLLNSF
HPHEEDLSSISATPLPEEFELQGFLALRPSFRNLDFSKGHQGITGDKEGQ
QRRIRQQRLISIGKWIADNQPRLIQCENEVGKLLFITEIPELILEDPSEA
KENLILQETSVIESLAADGSPGLKSVLSTSRNLSNNCDTGEKPVVTFKEN
IKTREVNRDQGRSFPPKEVRRDYSKGITVTKNDGKKDNNKRKTETKKCTL
EKLQETGKQNVAVQVKSQTELRKTPVSEARKTPVTQTPTQASNSQFIPIH
HPGAFPPLPSRPGFPPPTYVIPPPVAFSMGSGYTFPAGVSVPGTFLQPTA
HSPAGNQVQAGKQSHIPYSQQRPSGPGPMNQGPQQSQPPSQQPLTSLPAQ
PTAQSTSQLQVQALTQQQQSPTKAVPALGKSPPHHSGFQQYQQADASKQL
WNPPQVQGPLGKIMPVKQPYYLQTQDPIKLFEPSLQPPVMQQQPLEKKMK
PFPMEPYNHNPSEVKVPEFYWDSSYSMADNRSVMAQQANIDRRGKRSPGV
FRPEQDPVPRMPFEKSLLEKPSELMSHSSSFLSLTGFSLNQERYPNNSMF
NEVYGKNLTSSSKAELSPSMAPQETSLYSLFEGTPWSPSLPASSDHSTPA
SQSPHSSNPSSLPSSPPTHNHNSVPFSNFGPIGTPDNRDRRTADRWKTDK
PAMGGFGIDYLSATSSSESSWHQASTPSGTWTGHGPSMEDSSAVLMESLK
SIWSSSMMHPGPSALEQLLMQQKQKQQRGQGTMNPPH

Reference

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000116698 - Ensembl, maj 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000042772 - Ensembl, maj 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Ohnishi T, Yamashita A, Kashima I, Schell T, Anders KR, Grimson A, et al. (novembar 2003). "Phosphorylation of hUPF1 induces formation of mRNA surveillance complexes containing hSMG-5 and hSMG-7". Molecular Cell. 12 (5): 1187–200. doi:10.1016/S1097-2765(03)00443-X. PMID 14636577.
  6. ^ Fukuhara N, Ebert J, Unterholzner L, Lindner D, Izaurralde E, Conti E (februar 2005). "SMG7 is a 14-3-3-like adaptor in the nonsense-mediated mRNA decay pathway". Molecular Cell. 17 (4): 537–47. doi:10.1016/j.molcel.2005.01.010. PMID 15721257.
  7. ^ "Entrez Gene: SMG7 Smg-7 homolog, nonsense mediated mRNA decay factor (C. elegans)".
  8. ^ Yang L, Kraft VA, Pfeiffer S, Merl-Pham J, Bao X, An Y, et al. (juni 2020). "Nonsense-mediated decay factor SMG7 sensitizes cells to TNFα-induced apoptosis via CYLD tumor suppressor and the noncoding oncogene Pvt1". Molecular Oncology. 14 (10): 2420–2435. doi:10.1002/1878-0261.12754. PMC 7530794. PMID 32602581.
  9. ^ "UniProt, Q92540" (jezik: engleski). Pristupljeno 19. 12. 2021.

Dopunska literatura

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Vanjski linkovi

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