SLURP1
Lučeni Ly-6/uPAR-srodni protein 1 je protein koji je kod ljudi kodiran genom SLURP1.[5][6][7] Ima protivupalno djelovanje, kao supresor tumora i antagonizira nikotinske receptore.[8]
Aminokiselinska sekvenca
urediDužina polipeptidnog lanca je 103 aminokiseline, а molekulska težina 11.186 Da.[9]
| 10 | 20 | 30 | 40 | 50 | ||||
|---|---|---|---|---|---|---|---|---|
| MASRWAVQLL | LVAAWSMGCG | EALKCYTCKE | PMTSASCRTI | TRCKPEDTAC | ||||
| MTTLVTVEAE | YPFNQSPVVT | RSCSSSCVAT | DPDSIGAAHL | IFCCFRDLCN | ||||
| SEL |
Funkcija
urediProtein kodiran ovim genom član je porodice Ly6/uPAR, ali mu nedostaje signalna sekvenca za sidrenje GPI. Izlučuje se u krv[6], a ponekad se nalazi i u spermi, kada se ekstrahira u zigot koji se veže za receptor α7-acetilholina.[8] Prikazano je da djeluje kao endogeni supresor tumora smanjujući migraciju i invaziju stanica posredujući svoj vlastiti antitumorski učinak i antagonizirajući pro-maligne učinke nikotina.[8]
Mutacije u ovom genu povezane su s mljetskom bolešči (Mal de Meleda), rijetkim autosomno recesivnim kožnim poremećajem kojeg karakterizira upalna dlanskotabanska hiperkeratoza. To je posljedica gubitka SLURP1, što dovodi do disfunkcionalne epitelne diferencijacije.[10] and an increased secretion of the inflammatory cytokines TNFα, IL1, IL-6, and IL-8.[11][12]
Ovaj gen nalazi se u istoj hromosomskoj regiji kao i nekoliko članova porodice glikoproteinskih receptora Ly6/uPAR.[7]
Reference
uredi- ^ a b c GRCh38: Ensembl release 89: ENSG00000126233 - Ensembl, maj 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000022596 - Ensembl, maj 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Fischer J, Bouadjar B, Heilig R, Huber M, Lefèvre C, Jobard F, Macari F, Bakija-Konsuo A, Ait-Belkacem F, Weissenbach J, Lathrop M, Hohl D, Prud'homme JF (april 2001). "Mutations in the gene encoding SLURP-1 in Mal de Meleda". Human Molecular Genetics. 10 (8): 875–80. doi:10.1093/hmg/10.8.875. PMID 11285253.
- ^ a b Adermann K, Wattler F, Wattler S, Heine G, Meyer M, Forssmann WG, Nehls M (april 1999). "Structural and phylogenetic characterization of human SLURP-1, the first secreted mammalian member of the Ly-6/uPAR protein superfamily". Protein Science. 8 (4): 810–9. doi:10.1110/ps.8.4.810. PMC 2144295. PMID 10211827.
- ^ a b "Entrez Gene: SLURP1 secreted LY6/PLAUR domain containing 1".
- ^ a b c Throm VM, Männle D, Giese T, Bauer AS, Gaida MM, Kopitz J, Bruckner T, Plaschke K, Grekova SP, Felix K, Hackert T, Giese NA, Strobel O (februar 2018). "Endogenous CHRNA7-ligand SLURP1 as a potential tumor suppressor and anti-nicotinic factor in pancreatic cancer". Oncotarget. 9 (14): 11734–11751. doi:10.18632/oncotarget.24312. PMC 5837762. PMID 29545933.
- ^ "UniProt, P55000" (jezik: engleski). Pristupljeno 21. 9. 2021.
- ^ Favre B, Plantard L, Aeschbach L, Brakch N, Christen-Zaech S, de Viragh PA, Sergeant A, Huber M, Hohl D (februar 2007). "SLURP1 is a late marker of epidermal differentiation and is absent in Mal de Meleda". The Journal of Investigative Dermatology. 127 (2): 301–8. doi:10.1038/sj.jid.5700551. PMID 17008884.
- ^ Swamynathan S, Buela KA, Kinchington P, Lathrop KL, Misawa H, Hendricks RL, Swamynathan SK (decembar 2012). "Klf4 regulates the expression of Slurp1, which functions as an immunomodulatory peptide in the mouse cornea". Investigative Ophthalmology & Visual Science. 53 (13): 8433–46. doi:10.1167/iovs.12-10759. PMC 4113333. PMID 23139280.
- ^ Chernyavsky AI, Galitovskiy V, Shchepotin IB, Grando SA (2014). "Anti-inflammatory effects of the nicotinergic peptides SLURP-1 and SLURP-2 on human intestinal epithelial cells and immunocytes". BioMed Research International. 2014: 609086. doi:10.1155/2014/609086. PMC 4024406. PMID 24877120.
Dopunska literatura
uredi- Ridge RJ, Sloane NH (januar 1996). "Partial N-terminal amino acid sequence of the anti-neoplastic urinary protein (ANUP) and the anti-tumour effect of the N-terminal nonapeptide of the unique cytokine present in human granulocytes". Cytokine. 8 (1): 1–5. doi:10.1006/cyto.1996.0001. PMID 8742060.
- Fischer J, Bouadjar B, Heilig R, Fizames C, Prud'homme JF, Weissenbach J (1999). "Genetic linkage of Meleda disease to chromosome 8qter". European Journal of Human Genetics. 6 (6): 542–7. doi:10.1038/sj.ejhg.5200254. PMID 9887370.
- Eckl KM, Stevens HP, Lestringant GG, Westenberger-Treumann M, Traupe H, Hinz B, Frossard PM, Stadler R, Leigh IM, Nürnberg P, Reis A, Hennies HC (januar 2003). "Mal de Meleda (MDM) caused by mutations in the gene for SLURP-1 in patients from Germany, Turkey, Palestine, and the United Arab Emirates". Human Genetics. 112 (1): 50–6. doi:10.1007/s00439-002-0838-8. PMID 12483299. S2CID 317308.
- Marrakchi S, Audebert S, Bouadjar B, Has C, Lefèvre C, Munro C, Cure S, Jobard F, Morlot S, Hohl D, Prud'homme JF, Zahaf A, Turki H, Fischer J (mart 2003). "Novel mutations in the gene encoding secreted lymphocyte antigen-6/urokinase-type plasminogen activator receptor-related protein-1 (SLURP-1) and description of five ancestral haplotypes in patients with Mal de Meleda". The Journal of Investigative Dermatology. 120 (3): 351–5. doi:10.1046/j.1523-1747.2003.12062.x. PMID 12603845.
- Hu G, Yildirim M, Baysal V, Yerebakan O, Yilmaz E, Inaloz HS, Martinez-Mir A, Christiano AM, Celebi JT (juni 2003). "A recurrent mutation in the ARS (component B) gene encoding SLURP-1 in Turkish families with mal de Meleda: evidence of a founder effect". The Journal of Investigative Dermatology. 120 (6): 967–9. doi:10.1046/j.1523-1747.2003.12248.x. hdl:10261/39458. PMID 12787122.
- Chimienti F, Hogg RC, Plantard L, Lehmann C, Brakch N, Fischer J, Huber M, Bertrand D, Hohl D (novembar 2003). "Identification of SLURP-1 as an epidermal neuromodulator explains the clinical phenotype of Mal de Meleda". Human Molecular Genetics. 12 (22): 3017–24. doi:10.1093/hmg/ddg320. PMID 14506129.
- Charfeddine C, Mokni M, Ben Mousli R, Elkares R, Bouchlaka C, Boubaker S, Ghedamsi S, Baccouche D, Ben Osman A, Dellagi K, Abdelhak S (decembar 2003). "A novel missense mutation in the gene encoding SLURP-1 in patients with Mal de Meleda from northern Tunisia". The British Journal of Dermatology. 149 (6): 1108–15. doi:10.1111/j.1365-2133.2003.05606.x. PMID 14674887. S2CID 22999382.
- Mastrangeli R, Donini S, Kelton CA, He C, Bressan A, Milazzo F, Ciolli V, Borrelli F, Martelli F, Biffoni M, Serlupi-Crescenzi O, Serani S, Micangeli E, El Tayar N, Vaccaro R, Renda T, Lisciani R, Rossi M, Papoian R (2004). "ARS Component B: structural characterization, tissue expression and regulation of the gene and protein (SLURP-1) associated with Mal de Meleda". European Journal of Dermatology. 13 (6): 560–70. PMID 14721776.
- Mokni M, Charfeddine C, Ben Mously R, Baccouche D, Kaabi B, Ben Osman A, Dellagi K, Abdelhak S (mart 2004). "Heterozygous manifestations in female carriers of Mal de Meleda". Clinical Genetics. 65 (3): 244–6. doi:10.1111/j.0009-9163.2004.00224.x. PMID 14756676. S2CID 46140052.
- Chao SC, Lai FJ, Yang MH, Lee JY (april 2005). "Mal de Meleda in a taiwanese". Journal of the Formosan Medical Association = Taiwan Yi Zhi. 104 (4): 276–8. PMID 15909066.
- Arredondo J, Chernyavsky AI, Webber RJ, Grando SA (decembar 2005). "Biological effects of SLURP-1 on human keratinocytes". The Journal of Investigative Dermatology. 125 (6): 1236–41. doi:10.1111/j.0022-202X.2005.23973.x. PMID 16354194.
- Arredondo J, Chernyavsky AI, Grando SA (oktobar 2007). "Overexpression of SLURP-1 and -2 alleviates the tumorigenic action of tobacco-derived nitrosamine on immortalized oral epithelial cells". Biochemical Pharmacology. 74 (8): 1315–9. doi:10.1016/j.bcp.2007.06.026. PMC 2046218. PMID 17643396.