SLITRK5

SLITRK5
Identifikatori
Aliasi	SLITRK5
Vanjski ID-jevi	OMIM: 609680 MGI: 2679448 HomoloGene: 9193 GeneCards: SLITRK5
Lokacija gena (čovjek)
Hrom.	Hromosom 13 (čovjek)
Kraj	87,696,272 bp
Lokacija gena (miš)
Hrom.	Hromosom 14 (miš)
Kraj	111,920,573 bp
Obrazac RNK ekspresije
	Više referentnih podataka o ekspresiji
Ortolozi
	26050
	75409
	ENSG00000165300
	ENSMUSG00000033214
	O94991
	Q810B7
	NM_015567; NM_001384609; NM_001384610
	NM_029273; NM_198865; NM_001378768; NM_001378769; NM_001378770
	NP_056382
	NP_942565; NP_001365697; NP_001365698; NP_001365699
	Wikipodaci
Pogledaj/uredi – čovjek	Pogledaj/uredi – miš

SLIT i NTRK-liki protein 5 je protein koji je kod ljudi kodiran genom SLITRK5.^[5]^[6]^[7]

Aminokiselinska sekvenca uredi

Dužina polipeptidnog lanca je 958 aminokiselina, a molekulska težina 107.486 Da.^[8].

Simboli

C: Cistein
D: Asparaginska kiselina
E: Glutaminska kiselina
F: Fenilalanin
G: Glicin
H: Histidin
I: Izoleucin
K: Lizin
L: Leucin
M: Metionin
N: Asparagin

P: Prolin
Q: Glutamin
R: Arginin
S: Serin
T: Treonin
V: Valin
W: Triptofan
Y: Tirozin

10	20	30	40	50
MHTCCPPVTL	EQDLHRKMHS	WMLQTLAFAV	TSLVLSCAET	IDYYGEICDN
ACPCEEKDGI	LTVSCENRGI	ISLSEISPPR	FPIYHLLLSG	NLLNRLYPNE
FVNYTGASIL	HLGSNVIQDI	ETGAFHGLRG	LRRLHLNNNK	LELLRDDTFL
GLENLEYLQV	DYNYISVIEP	NAFGKLHLLQ	VLILNDNLLS	SLPNNLFRFV
PLTHLDLRGN	RLKLLPYVGL	LQHMDKVVEL	QLEENPWNCS	CELISLKDWL
DSISYSALVG	DVVCETPFRL	HGRDLDEVSK	QELCPRRLIS	DYEMRPQTPL
STTGYLHTTP	ASVNSVATSS	SAVYKPPLKP	PKGTRQPNKP	RVRPTSRQPS
KDLGYSNYGP	SIAYQTKSPV	PLECPTACSC	NLQISDLGLN	VNCQERKIES
IAELQPKPYN	PKKMYLTENY	IAVVRRTDFL	EATGLDLLHL	GNNRISMIQD
RAFGDLTNLR	RLYLNGNRIE	RLSPELFYGL	QSLQYLFLQY	NLIREIQSGT
FDPVPNLQLL	FLNNNLLQAM	PSGVFSGLTL	LRLNLRSNHF	TSLPVSGVLD
QLKSLIQIDL	HDNPWDCTCD	IVGMKLWVEQ	LKVGVLVDEV	ICKAPKKFAE
TDMRSIKSEL	LCPDYSDVVV	STPTPSSIQV	PARTSAVTPA	VRLNSTGAPA
SLGAGGGASS	VPLSVLILSL	LLVFIMSVFV	AAGLFVLVMK	RRKKNQSDHT
STNNSDVSSF	NMQYSVYGGG	GGTGGHPHAH	VHHRGPALPK	VKTPAGHVYE
YIPHPLGHMC	KNPIYRSREG	NSVEDYKDLH	ELKVTYSSNH	HLQQQQQPPP
PPQQPQQQPP	PQLQLQPGEE	ERRESHHLRS	PAYSVSTIEP	REDLLSPVQD
ADRFYRGILE	PDKHCSTTPA	GNSLPEYPKF	PCSPAAYTFS	PNYDLRRPHQ
YLHPGAGDSR	LREPVLYSPP	SAVFVEPNRN	EYLELKAKLN	VEPDYLEVLE
KQTTFSQF

Funkcija uredi

Članovi porodice SLITRK, poput SLITRK5, integralni su membranski proteini s dva N-terminalna ponavljajuća domena (LRR) bogata leucinom, sličnea onima SLIT proteina (vidi SLIT1; MIM 603742). Većina SLITRK-ova, uključujući SLITRK5, također imaju C-terminalne regije koje dijele homologiju s receptorima za neurotropine (vidi NTRK1; MIM 191315). SLITRK se eksprimiraju pretežno u neuronskim tkivima i imaju aktivnost moduliranja neurita (Aruga et al., 2003). [Dobavljač OMIM] (Aruga et al., 2003).[supplied by OMIM]^[7]

Reference uredi

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000165300 - Ensembl, maj 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000033214 - Ensembl, maj 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Nagase T, Ishikawa K, Suyama M, Kikuno R, Hirosawa M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (decembar 1998). "Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Research. 5 (6): 355–64. doi:10.1093/dnares/5.6.355. PMID 10048485.
^ Aruga J, Yokota N, Mikoshiba K (oktobar 2003). "Human SLITRK family genes: genomic organization and expression profiling in normal brain and brain tumor tissue". Gene. 315: 87–94. doi:10.1016/S0378-1119(03)00715-7. PMID 14557068.
^ ^a ^b "Entrez Gene: SLITRK5 SLIT and NTRK-like family, member 5".
^ "UniProt, O94991". Pristupljeno 5. 8. 2021.

Dopunska literatura uredi

Amanchy R, Kalume DE, Iwahori A, Zhong J, Pandey A (2006). "Phosphoproteome analysis of HeLa cells using stable isotope labeling with amino acids in cell culture (SILAC)". Journal of Proteome Research. 4 (5): 1661–71. doi:10.1021/pr050134h. PMID 16212419.
Aruga J, Mikoshiba K (septembar 2003). "Identification and characterization of Slitrk, a novel neuronal transmembrane protein family controlling neurite outgrowth". Molecular and Cellular Neurosciences. 24 (1): 117–29. doi:10.1016/S1044-7431(03)00129-5. PMID 14550773.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000165300 - Ensembl, maj 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000033214 - Ensembl, maj 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10048485-5] Nagase T, Ishikawa K, Suyama M, Kikuno R, Hirosawa M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (decembar 1998). "Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Research. 5 (6): 355–64. doi:10.1093/dnares/5.6.355. PMID 10048485.

[pmid14557068-6] Aruga J, Yokota N, Mikoshiba K (oktobar 2003). "Human SLITRK family genes: genomic organization and expression profiling in normal brain and brain tumor tissue". Gene. 315: 87–94. doi:10.1016/S0378-1119(03)00715-7. PMID 14557068.

[entrez-7] "Entrez Gene: SLITRK5 SLIT and NTRK-like family, member 5".

[UniProt-8] "UniProt, O94991". Pristupljeno 5. 8. 2021.

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