Cinkov transporter ZIP1 jest protein koji je kod ljudi kodiran genom SLC39A1 sa hromosoma 1.[5][6][7]

SLC50A1
Identifikatori
AliasiSLC50A1
Vanjski ID-jeviOMIM: 613683 MGI: 107417 HomoloGene: 40647 GeneCards: SLC50A1
Lokacija gena (čovjek)
Hromosom 1 (čovjek)
Hrom.Hromosom 1 (čovjek)[1]
Hromosom 1 (čovjek)
Genomska lokacija za SLC50A1
Genomska lokacija za SLC50A1
Bend1q22Početak155,135,344 bp[1]
Kraj155,138,857 bp[1]
Lokacija gena (miš)
Hromosom 3 (miš)
Hrom.Hromosom 3 (miš)[2]
Hromosom 3 (miš)
Genomska lokacija za SLC50A1
Genomska lokacija za SLC50A1
Bend3 F1|3 39.04 cMPočetak89,175,553 bp[2]
Kraj89,177,877 bp[2]
Ontologija gena
Molekularna funkcija glucoside transmembrane transporter activity
sugar transmembrane transporter activity
Ćelijska komponenta jedro
Golđijeva membrana
membrana
integral component of membrane
Golđijev aparat
Endomembranski sistem
ćelijska membrana
Biološki proces GO:0006859 carbohydrate transport
epigenetic maintenance of chromatin in transcription-competent conformation
glucoside transport
hexose transmembrane transport
Izvori:Amigo / QuickGO
Ortolozi
VrsteČovjekMiš
Entrez
Ensembl
UniProt
RefSeq (mRNK)
NM_001122837
NM_001122839
NM_001287586
NM_001287587
NM_001287588

NM_001287589
NM_001287590
NM_001287591
NM_001287592
NM_018845

NM_009057

RefSeq (bjelančevina)
NP_001116309
NP_001116311
NP_001274515
NP_001274516
NP_001274517

NP_001274518
NP_001274519
NP_001274520
NP_001274521
NP_061333

NP_033083

Lokacija (UCSC)Chr 1: 155.14 – 155.14 MbChr 3: 89.18 – 89.18 Mb
PubMed pretraga[3][4]
Wikipodaci
Pogledaj/uredi – čovjekPogledaj/uredi – miš

Aminokiselinska sekvenca

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Dužina polipeptidnog lanca je 324 aminokiselina, a molekulska težina 34.250 Da.[8]

1020304050
MGPWGEPELLVWRPEAVASEPPVPVGLEVKLGALVLLLVLTLLCSLVPIC
VLRRPGANHEGSASRQKALSLVSCFAGGVFLATCLLDLLPDYLAAIDEAL
AALHVTLQFPLQEFILAMGFFLVLVMEQITLAYKEQSGPSPLEETRALLG
TVNGGPQHWHDGPGVPQASGAPATPSALRACVLVFSLALHSVFEGLAVGL
QRDRARAMELCLALLLHKGILAVSLSLRLLQSHLRAQVVAGCGILFSCMT
PLGIGLGAALAESAGPLHQLAQSVLEGMAAGTFLYITFLEILPQELASSE
QRILKVILLLAGFALLTGLLFIQI

Funkcija

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Protein ZIP1 je odgovoran za aktivni transport cinka u ćelijama prostate. U mnogim karcinomima prostate SLC39A1 je utišan zbog čega ćelije raka prostate imaju nizak sadržaj cinka.[9]

Također pogledajte

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Reference

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000169241 - Ensembl, maj 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000027953 - Ensembl, maj 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Lioumi M, Ferguson CA, Sharpe PT, Freeman T, Marenholz I, Mischke D, Heizmann C, Ragoussis J (Feb 2000). "Isolation and characterization of human and mouse ZIRTL, a member of the IRT1 family of transporters, mapping within the epidermal differentiation complex". Genomics. 62 (2): 272–80. doi:10.1006/geno.1999.5993. PMID 10610721.
  6. ^ Gaither LA, Eide DJ (Mar 2000). "Functional expression of the human hZIP2 zinc transporter". J Biol Chem. 275 (8): 5560–4. doi:10.1074/jbc.275.8.5560. PMID 10681536.
  7. ^ "Entrez Gene: SLC39A1 solute carrier family 39 (zinc transporter), member 1".
  8. ^ "UniProt, Q9NY26" (jezik: engleski). Pristupljeno 19. 12. 2021.
  9. ^ Costello LC, Franklin RB (2006). "The clinical relevance of the metabolism of prostate cancer; zinc and tumor suppression: connecting the dots". Mol. Cancer. 5: 17. doi:10.1186/1476-4598-5-17. PMC 1481516. PMID 16700911.

Dopunska literatura

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Vanjski linkovi

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