SLC50A1

SLC50A1
Identifikatori
Aliasi	SLC50A1
Vanjski ID-jevi	OMIM: 613683 MGI: 107417 HomoloGene: 40647 GeneCards: SLC50A1
Lokacija gena (čovjek)
Hrom.	Hromosom 1 (čovjek)
Kraj	155,138,857 bp
Lokacija gena (miš)
Hrom.	Hromosom 3 (miš)
Kraj	89,177,877 bp
Ontologija gena
Molekularna funkcija	• glucoside transmembrane transporter activity; • sugar transmembrane transporter activity;
Ćelijska komponenta	• jedro; • Golđijeva membrana; • membrana; • integral component of membrane; • Golđijev aparat; • Endomembranski sistem; • ćelijska membrana;
Biološki proces	• GO:0006859 carbohydrate transport; • epigenetic maintenance of chromatin in transcription-competent conformation; • glucoside transport; • hexose transmembrane transport;
	Izvori:Amigo / QuickGO
Ortolozi
	55974
	19729
	ENSG00000169241
	ENSMUSG00000027953
	Q9BRV3
	Q9CXK4
NM_001122837; NM_001122839; NM_001287586; NM_001287587; NM_001287588;
	NM_001287589; NM_001287590; NM_001287591; NM_001287592; NM_018845
	NM_009057
NP_001116309; NP_001116311; NP_001274515; NP_001274516; NP_001274517;
	NP_001274518; NP_001274519; NP_001274520; NP_001274521; NP_061333
	NP_033083
	Wikipodaci
Pogledaj/uredi – čovjek	Pogledaj/uredi – miš

Cinkov transporter ZIP1 jest protein koji je kod ljudi kodiran genom SLC39A1 sa hromosoma 1.^[5]^[6]^[7]

Aminokiselinska sekvenca uredi

Dužina polipeptidnog lanca je 324 aminokiselina, a molekulska težina 34.250 Da.^[8]

C: Cistein

D: Asparaginska kiselina

E: Glutaminska kiselina

F: Fenilalanin

G: Glicin

H: Histidin

I: Izoleucin

K: Lizin

L: Leucin

M: Metionin

N: Asparagin

P: Prolin

Q: Glutamin

R: Arginin

S: Serin

T: Treonin

V: Valin

W: Triptofan

Y: Tirozin

10	20	30	40	50
MGPWGEPELL	VWRPEAVASE	PPVPVGLEVK	LGALVLLLVL	TLLCSLVPIC
VLRRPGANHE	GSASRQKALS	LVSCFAGGVF	LATCLLDLLP	DYLAAIDEAL
AALHVTLQFP	LQEFILAMGF	FLVLVMEQIT	LAYKEQSGPS	PLEETRALLG
TVNGGPQHWH	DGPGVPQASG	APATPSALRA	CVLVFSLALH	SVFEGLAVGL
QRDRARAMEL	CLALLLHKGI	LAVSLSLRLL	QSHLRAQVVA	GCGILFSCMT
PLGIGLGAAL	AESAGPLHQL	AQSVLEGMAA	GTFLYITFLE	ILPQELASSE
QRILKVILLL	AGFALLTGLL	FIQI

Funkcija uredi

Protein ZIP1 je odgovoran za aktivni transport cinka u ćelijama prostate. U mnogim karcinomima prostate SLC39A1 je utišan zbog čega ćelije raka prostate imaju nizak sadržaj cinka.^[9]

Također pogledajte uredi

Porodica rastvornih nosača

Reference uredi

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000169241 - Ensembl, maj 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000027953 - Ensembl, maj 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Lioumi M, Ferguson CA, Sharpe PT, Freeman T, Marenholz I, Mischke D, Heizmann C, Ragoussis J (Feb 2000). "Isolation and characterization of human and mouse ZIRTL, a member of the IRT1 family of transporters, mapping within the epidermal differentiation complex". Genomics. 62 (2): 272–80. doi:10.1006/geno.1999.5993. PMID 10610721.
^ Gaither LA, Eide DJ (Mar 2000). "Functional expression of the human hZIP2 zinc transporter". J Biol Chem. 275 (8): 5560–4. doi:10.1074/jbc.275.8.5560. PMID 10681536.
^ "Entrez Gene: SLC39A1 solute carrier family 39 (zinc transporter), member 1".
^ "UniProt, Q9NY26" (jezik: engleski). Pristupljeno 19. 12. 2021.
^ Costello LC, Franklin RB (2006). "The clinical relevance of the metabolism of prostate cancer; zinc and tumor suppression: connecting the dots". Mol. Cancer. 5: 17. doi:10.1186/1476-4598-5-17. PMC 1481516. PMID 16700911.

Dopunska literatura uredi

Lai CH, Chou CY, Ch'ang LY, et al. (2000). "Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics". Genome Res. 10 (5): 703–13. doi:10.1101/gr.10.5.703. PMC 310876. PMID 10810093.
Gaither LA, Eide DJ (2001). "The human ZIP1 transporter mediates zinc uptake in human K562 erythroleukemia cells". J. Biol. Chem. 276 (25): 22258–64. doi:10.1074/jbc.M101772200. PMID 11301334.
Milon B, Dhermy D, Pountney D, et al. (2001). "Differential subcellular localization of hZip1 in adherent and non-adherent cells". FEBS Lett. 507 (3): 241–6. doi:10.1016/S0014-5793(01)02950-7. PMID 11696349.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Franklin RB, Ma J, Zou J, et al. (2003). "Human ZIP1 is a major zinc uptake transporter for the accumulation of zinc in prostate cells". J. Inorg. Biochem. 96 (2–3): 435–42. doi:10.1016/S0162-0134(03)00249-6. PMC 4465841. PMID 12888280.
Dufner-Beattie J, Langmade SJ, Wang F, et al. (2004). "Structure, function, and regulation of a subfamily of mouse zinc transporter genes". J. Biol. Chem. 278 (50): 50142–50. doi:10.1074/jbc.M304163200. PMID 14525987.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Franklin RB, Feng P, Milon B, et al. (2006). "hZIP1 zinc uptake transporter down regulation and zinc depletion in prostate cancer". Mol. Cancer. 4: 32. doi:10.1186/1476-4598-4-32. PMC 1243239. PMID 16153295.
Tang Z, Sahu SN, Khadeer MA, et al. (2006). "Overexpression of the ZIP1 zinc transporter induces an osteogenic phenotype in mesenchymal stem cells". Bone. 38 (2): 181–98. doi:10.1016/j.bone.2005.08.010. PMID 16203195.
Otsuki T, Ota T, Nishikawa T, et al. (2007). "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries". DNA Res. 12 (2): 117–26. doi:10.1093/dnares/12.2.117. PMID 16303743.
Huang L, Kirschke CP (2007). "A di-leucine sorting signal in ZIP1 (SLC39A1) mediates endocytosis of the protein". FEBS J. 274 (15): 3986–97. doi:10.1111/j.1742-4658.2007.05933.x. PMID 17635580. S2CID 21792127.

Vanjski linkovi uredi

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000169241 - Ensembl, maj 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000027953 - Ensembl, maj 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10610721-5] Lioumi M, Ferguson CA, Sharpe PT, Freeman T, Marenholz I, Mischke D, Heizmann C, Ragoussis J (Feb 2000). "Isolation and characterization of human and mouse ZIRTL, a member of the IRT1 family of transporters, mapping within the epidermal differentiation complex". Genomics. 62 (2): 272–80. doi:10.1006/geno.1999.5993. PMID 10610721.

[pmid10681536-6] Gaither LA, Eide DJ (Mar 2000). "Functional expression of the human hZIP2 zinc transporter". J Biol Chem. 275 (8): 5560–4. doi:10.1074/jbc.275.8.5560. PMID 10681536.

[entrez-7] "Entrez Gene: SLC39A1 solute carrier family 39 (zinc transporter), member 1".

[UniProt-8] "UniProt, Q9NY26" (jezik: engleski). Pristupljeno 19. 12. 2021.

[pmid16700911-9] Costello LC, Franklin RB (2006). "The clinical relevance of the metabolism of prostate cancer; zinc and tumor suppression: connecting the dots". Mol. Cancer. 5: 17. doi:10.1186/1476-4598-5-17. PMC 1481516. PMID 16700911.

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