SLC10A4

SLC10A4
Identifikatori
Aliasi	SLC10A4
Vanjski ID-jevi	MGI: 3606480 HomoloGene: 15495 GeneCards: SLC10A4
Lokacija gena (čovjek)
Hrom.	Hromosom 4 (čovjek)
Kraj	48,489,526 bp
Lokacija gena (miš)
Hrom.	Hromosom 5 (miš)
Kraj	73,170,298 bp
Ontologija gena
Molekularna funkcija	• symporter activity; • bile acid:sodium symporter activity;
Ćelijska komponenta	• integral component of membrane; • ćelijska membrana; • membrana; • integral component of synaptic vesicle membrane; • dopaminergic synapse; • cholinergic synapse; • serotonergic synapse;
Biološki proces	• ion transport; • transmembrane transport; • sodium ion transport; • bile acid and bile salt transport; • adult behavior; • regulation of neurotransmitter loading into synaptic vesicle;
	Izvori:Amigo / QuickGO
Ortolozi
	201780
	231290
	ENSG00000145248
	ENSMUSG00000029219
	Q96EP9
	Q3UEZ8
	NM_152679
	NM_173403
	NP_689892
	NP_775579
	Wikipodaci
Pogledaj/uredi – čovjek	Pogledaj/uredi – miš

Član 4 porodice rastvornih nosača 10 jest protein koji je kod ljudi kodiran genom SLC10A4 sa hromosoma 4.^[5] Kod miševa, čini se da podstiče zakiseljavanje sinapsnih vezikula koje sadrže monoamine, poboljšavajući njihovo uzimanje i koeksprimira se s VMAT2 i VAChT.^[6]

Aminokiselinska sekvenca

Dužina polipeptidnog lanca je 437 aminokiselina, а molekulska težina 46.504 Da.^[7]

C: Cistein

D: Asparaginska kiselina

E: Glutaminska kiselina

F: Fenilalanin

G: Glicin

H: Histidin

I: Izoleucin

K: Lizin

L: Leucin

M: Metionin

N: Asparagin

P: Prolin

Q: Glutamin

R: Arginin

S: Serin

T: Treonin

V: Valin

W: Triptofan

Y: Tirozin

10	20	30	40	50
MDGNDNVTLL	FAPLLRDNYT	LAPNASSLGP	GTDLALAPAS	SAGPGPGLSL
GPGPSFGFSP	GPTPTPEPTT	SGLAGGAASH	GPSPFPRPWA	PHALPFWDTP
LNHGLNVFVG	AALCITMLGL	GCTVDVNHFG	AHVRRPVGAL	LAALCQFGLL
PLLAFLLALA	FKLDEVAAVA	VLLCGCCPGG	NLSNLMSLLV	DGDMNLSIIM
TISSTLLALV	LMPLCLWIYS	WAWINTPIVQ	LLPLGTVTLT	LCSTLIPIGL
GVFIRYKYSR	VADYIVKVSL	WSLLVTLVVL	FIMTGTMLGP	ELLASIPAAV
YVIAIFMPLA	GYASGYGLAT	LFHLPPNCKR	TVCLETGSQN	VQLCTAILKL
AFPPQFIGSM	YMFPLLYALF	QSAEAGIFVL	IYKMYGSEML	HKRDPLDEDE
DTDISYKKLK	EEEMADTSYG	TVKAENIIMM	ETAQTSL

Reference

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000145248 - Ensembl, maj 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000029219 - Ensembl, maj 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: Solute carrier family 10 member 4". Pristupljeno 17. 4. 2016.
^ Larhammar M, Patra K, Blunder M, Emilsson L, Peuckert C, Arvidsson E, Rönnlund D, Preobraschenski J, Birgner C, Limbach C, Widengren J, Blom H, Jahn R, Wallén-Mackenzie Å, Kullander K (mart 2015). "SLC10A4 is a vesicular amine-associated transporter modulating dopamine homeostasis". Biological Psychiatry. 77 (6): 526–36. doi:10.1016/j.biopsych.2014.07.017. hdl:11858/00-001M-0000-0025-7742-E. PMID 25176177. S2CID 6665524.
^ "UniProt, Q96EP9" (jezik: engleski). Pristupljeno 30. 10. 2021.

Dopunska literatura

Splinter PL, Lazaridis KN, Dawson PA, LaRusso NF (novembar 2006). "Cloning and expression of SLC10A4, a putative organic anion transport protein". World Journal of Gastroenterology. 12 (42): 6797–805. doi:10.3748/wjg.v12.i42.6797. PMC 4087434. PMID 17106928.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000145248 - Ensembl, maj 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000029219 - Ensembl, maj 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: Solute carrier family 10 member 4". Pristupljeno 17. 4. 2016.

[pmid25176177-6] Larhammar M, Patra K, Blunder M, Emilsson L, Peuckert C, Arvidsson E, Rönnlund D, Preobraschenski J, Birgner C, Limbach C, Widengren J, Blom H, Jahn R, Wallén-Mackenzie Å, Kullander K (mart 2015). "SLC10A4 is a vesicular amine-associated transporter modulating dopamine homeostasis". Biological Psychiatry. 77 (6): 526–36. doi:10.1016/j.biopsych.2014.07.017. hdl:11858/00-001M-0000-0025-7742-E. PMID 25176177. S2CID 6665524.

[UniProt-7] "UniProt, Q96EP9" (jezik: engleski). Pristupljeno 30. 10. 2021.

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