SEPT3

Neuronski-specifični septin-3 jest protein koji je kod ljudi kodiran genom SEPT3 sa hromosoma 22.

SEPT3
Dostupne strukture PDB Pretraga ortologa: PDBe RCSB Spisak PDB ID kodova 3SOP, 4Z51, 4Z54
Identifikatori
Aliasi	SEPTIN3
Vanjski ID-jevi	OMIM: 608314 MGI: 1345148 HomoloGene: 99740 GeneCards: SEPTIN3
Lokacija gena (čovjek) Hrom. Hromosom 22 (čovjek) Bend 22q13.2 Početak 41,969,475 bp Kraj 41,998,221 bp
Lokacija gena (miš) Hrom. Hromosom 15 (miš) Bend 15|15 E1 Početak 82,153,003 bp Kraj 82,178,775 bp
Ontologija gena Molekularna funkcija • nucleotide binding • GTP binding • GO:0001948, GO:0016582 vezivanje za proteine • vezivanje identičnih proteina • molekularna funkcija • GO:0006184 GTPase activity • GO:0032947 molecular adaptor activity Ćelijska komponenta • citoplazma • međućelijske veze • sinapsa • citoskelet • septin ring • microtubule cytoskeleton • septin complex • septin filament array • neuron projection • presynaptic cytoskeleton • presynapse Biološki proces • ćelijski ciklus • Ćelijska dioba • mitotic cytokinesis • septin ring assembly • cilium assembly • cytoskeleton-dependent cytokinesis Izvori:Amigo / QuickGO
Ortolozi
Vrste	Čovjek	Miš
Entrez	55964	24050
Ensembl	ENSG00000100167	ENSMUSG00000022456
UniProt	Q9UH03	Q9Z1S5
RefSeq (mRNK)	NM_145734 NM_019106 NM_145733 NM_001363845	NM_011889 NM_001358836 NM_001358837 NM_001368642 NM_001368643 NM_001368644 NM_001368645 NM_001368646 NM_001368647 NM_001368784 NM_001368785
RefSeq (bjelančevina)	NP_061979 NP_663786 NP_001350774	NP_036019 NP_001345765 NP_001345766
Lokacija (UCSC)	Chr 22: 41.97 – 42 Mb	Chr 15: 82.15 – 82.18 Mb
PubMed pretraga
Wikipodaci
Pogledaj/uredi – čovjek Pogledaj/uredi – miš

Aminokiselinska sekvenca

Dužina polipeptidnog lanca je 358 aminokiselina, a molekulska težina 40.704 Da.

• C: Cistein
• D: Asparaginska kiselina
• E: Glutaminska kiselina
• F: Fenilalanin
• G: Glicin
• H: Histidin
• I: Izoleucin
• K: Lizin
• L: Leucin
• M: Metionin
• N: Asparagin
• P: Prolin
• Q: Glutamin
• R: Arginin
• S: Serin
• T: Treonin
• V: Valin
• W: Triptofan
• Y: Tirozin

10		20		30		40		50
MSKGLPETRT		DAAMSELVPE		PRPKPAVPMK		PMSINSNLLG		YIGIDTIIEQ
MRKKTMKTGF		DFNIMVVGQS		GLGKSTLVNT		LFKSQVSRKA		SSWNREEKIP
KTVEIKAIGH		VIEEGGVKMK		LTVIDTPGFG		DQINNENCWE		PIEKYINEQY
EKFLKEEVNI		ARKKRIPDTR		VHCCLYFISP		TGHSLRPLDL		EFMKHLSKVV
NIIPVIAKAD		TMTLEEKSEF		KQRVRKELEV		NGIEFYPQKE		FDEDLEDKTE
NDKIRQESMP		FAVVGSDKEY		QVNGKRVLGR		KTPWGIIEVE		NLNHCEFALL
RDFVIRTHLQ		DLKEVTHNIH		YETYRAKRLN		DNGGLPPGEG		LLGTVLPPVP
ATPCPTAE

Funkcija

Ovaj gen pripada septinskoj porodici GTPaza. Članovi ove porodice su potrebni za citokinezu. Ekspresija je pojačana retinoinskom kiselinom u ljudskoj teratokarcinomskoj ćelijskoj liniji. Specifična funkcija ovog gena nije utvrđena. Alternativna prerada ovog gena rezultira višestrukim varijantama transkripta.

Dopunska literatura

• Bonaldo MF, Lennon G, Soares MB (septembar 1996). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Research. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
• Hartley JL, Temple GF, Brasch MA (novembar 2000). "DNA cloning using in vitro site-specific recombination". Genome Research. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
• Wiemann S, Weil B, Wellenreuther R, Gassenhuber J, Glassl S, Ansorge W, Böcher M, Blöcker H, Bauersachs S, Blum H, Lauber J, Düsterhöft A, Beyer A, Köhrer K, Strack N, Mewes HW, Ottenwälder B, Obermaier B, Tampe J, Heubner D, Wambutt R, Korn B, Klein M, Poustka A (mart 2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Research. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
• Methner A, Leypoldt F, Joost P, Lewerenz J (april 2001). "Human septin 3 on chromosome 22q13.2 is upregulated by neuronal differentiation". Biochemical and Biophysical Research Communications. 283 (1): 48–56. doi:10.1006/bbrc.2001.4741. PMID 11322766.
• Xue J, Milburn PJ, Hanna BT, Graham ME, Rostas JA, Robinson PJ (august 2004). "Phosphorylation of septin 3 on Ser-91 by cGMP-dependent protein kinase-I in nerve terminals". The Biochemical Journal. 381 (Pt 3): 753–60. doi:10.1042/BJ20040455. PMC 1133885. PMID 15107017.
• Collins JE, Wright CL, Edwards CA, Davis MP, Grinham JA, Cole CG, Goward ME, Aguado B, Mallya M, Mokrab Y, Huckle EJ, Beare DM, Dunham I (2005). "A genome annotation-driven approach to cloning the human ORFeome". Genome Biology. 5 (10): R84. doi:10.1186/gb-2004-5-10-r84. PMC 545604. PMID 15461802.
• Xue J, Tsang CW, Gai WP, Malladi CS, Trimble WS, Rostas JA, Robinson PJ (novembar 2004). "Septin 3 (G-septin) is a developmentally regulated phosphoprotein enriched in presynaptic nerve terminals". Journal of Neurochemistry. 91 (3): 579–90. doi:10.1111/j.1471-4159.2004.02755.x. PMID 15485489.
• Wiemann S, Arlt D, Huber W, Wellenreuther R, Schleeger S, Mehrle A, Bechtel S, Sauermann M, Korf U, Pepperkok R, Sültmann H, Poustka A (oktobar 2004). "From ORFeome to biology: a functional genomics pipeline". Genome Research. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
• Mehrle A, Rosenfelder H, Schupp I, del Val C, Arlt D, Hahne F, Bechtel S, Simpson J, Hofmann O, Hide W, Glatting KH, Huber W, Pepperkok R, Poustka A, Wiemann S (januar 2006). "The LIFEdb database in 2006". Nucleic Acids Research. 34 (Database issue): D415-8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.