RSU1

Ras supresorski protein 1 je protein koji je kod ljudi kodiran genom RSU1.

RSU1
Identifikatori
Aliasi	RSU1
Vanjski ID-jevi	OMIM: 179555 MGI: 103040 HomoloGene: 7521 GeneCards: RSU1
Lokacija gena (čovjek) Hrom. Hromosom 10 (čovjek) Bend 10p13 Početak 16,590,611 bp Kraj 16,817,463 bp
Lokacija gena (miš) Hrom. Hromosom 2 (miš) Bend 2|2 A1 Početak 13,081,632 bp Kraj 13,276,226 bp
Obrazac RNK ekspresije Više referentnih podataka o ekspresiji
Ontologija gena Molekularna funkcija • GO:0001948, GO:0016582 vezivanje za proteine Ćelijska komponenta • citosol • Egzosom • focal adhesion Biološki proces • GO:0032320, GO:0032321, GO:0032855, GO:0043089, GO:0032854 positive regulation of GTPase activity • regulation of cell-substrate adhesion • GO:0072468 Transdukcija signala • positive regulation of cell-substrate adhesion Izvori:Amigo / QuickGO
Ortolozi
Vrste	Čovjek	Miš
Entrez	6251	20163
Ensembl	ENSG00000148484	ENSMUSG00000026727
UniProt	Q15404	Q01730
RefSeq (mRNK)	NM_012425 NM_152724	NM_009105
RefSeq (bjelančevina)	NP_036557 NP_689937	n/a
Lokacija (UCSC)	Chr 10: 16.59 – 16.82 Mb	Chr 2: 13.08 – 13.28 Mb
PubMed pretraga
Wikipodaci
Pogledaj/uredi – čovjek Pogledaj/uredi – miš

Ovaj gen kodira protein koji je uključen u put transdukcije Ras signala, inhibiciju rasta i procese diferencijacije izazvane nervnim faktorom rasta, kako je utvrđeno u studijama mišje ćelijske linije. Kod miša, kodirani protein je u početku izoliran na osnovu njegove sposobnosti da inhibira v-Ras transformaciju. Prijavljeno je više alternativno prerađenih varijanti transkripta za ovaj gen; jedna od ovih varijanti pronađena je samo u tumorima glioma. Također se vidi da RSU-1 djeluje kao strukturni protein u integrinski posredovanim kompleksima fokusne adhezije. Snažno se veže za protein PINCH.

Aminokiselinska sekvenca

Dužina polipeptidnog lanca je 277 aminokiselina, а molekulska težina 31.540 Da.

10		20		30		40		50
MSKSLKKLVE		ESREKNQPEV		DMSDRGISNM		LDVNGLFTLS		HITQLVLSHN
KLTMVPPNIA		ELKNLEVLNF		FNNQIEELPT		QISSLQKLKH		LNLGMNRLNT
LPRGFGSLPA		LEVLDLTYNN		LSENSLPGNF		FYLTTLRALY		LSDNDFEILP
PDIGKLTKLQ		ILSLRDNDLI		SLPKEIGELT		QLKELHIQGN		RLTVLPPELG
NLDLTGQKQV		FKAENNPWVT		PIADQFQLGV		SHVFEYIRSE		TYKYLYGRHM
QANPEPPKKN		NDKSKKISRK		PLAAKNR

C: Cistein

D: Asparaginska kiselina

E: Glutaminska kiselina

F: Fenilalanin

G: Glicin

H: Histidin

I: Izoleucin

K: Lizin

L: Leucin

M: Metionin

N: Asparagin

P: Prolin

Q: Glutamin

R: Arginin

S: Serin

T: Treonin

V: Valin

W: Triptofan

Y: Tirozin

Dopunska literatura

• Cutler ML, Bassin RH, Zanoni L, Talbot N (1992). "Isolation of rsp-1, a novel cDNA capable of suppressing v-Ras transformation". Mol. Cell. Biol. 12 (9): 3750–6. doi:10.1128/MCB.12.9.3750. PMC 360236. PMID 1508180.
• Tsuda T, Marinetti MR, Masuelli L, Cutler ML (1995). "The Ras suppressor RSU-1 localizes to 10p13 and its expression in the U251 glioblastoma cell line correlates with a decrease in growth rate and tumorigenic potential". Oncogene. 11 (2): 397–403. PMID 7624154.
• Matoba R, Okubo K, Hori N, et al. (1994). "The addition of 5'-coding information to a 3'-directed cDNA library improves analysis of gene expression". Gene. 146 (2): 199–207. doi:10.1016/0378-1119(94)90293-3. PMID 8076819.
• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Masuelli L, Cutler ML (1996). "Increased expression of the Ras suppressor Rsu-1 enhances Erk-2 activation and inhibits Jun kinase activation". Mol. Cell. Biol. 16 (10): 5466–76. doi:10.1128/MCB.16.10.5466. PMC 231547. PMID 8816460.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Chunduru S, Kawami H, Gullick R, et al. (2003). "Identification of an alternatively spliced RNA for the Ras suppressor RSU-1 in human gliomas". J. Neurooncol. 60 (3): 201–11. doi:10.1023/A:1021130620178. PMID 12510772. S2CID 34539.
• Gevaert K, Goethals M, Martens L, et al. (2004). "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides". Nat. Biotechnol. 21 (5): 566–9. doi:10.1038/nbt810. PMID 12665801. S2CID 23783563.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Aboulaich N, Vainonen JP, Strålfors P, Vener AV (2005). "Vectorial proteomics reveal targeting, phosphorylation and specific fragmentation of polymerase I and transcript release factor (PTRF) at the surface of caveolae in human adipocytes". Biochem. J. 383 (Pt 2): 237–48. doi:10.1042/BJ20040647. PMC 1134064. PMID 15242332.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Dougherty GW, Chopp T, Qi SM, Cutler ML (2005). "The Ras suppressor Rsu-1 binds to the LIM 5 domain of the adaptor protein PINCH1 and participates in adhesion-related functions". Exp. Cell Res. 306 (1): 168–79. doi:10.1016/j.yexcr.2005.01.025. PMID 15878342.
• Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein–protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.