Aminokiselinska sekvenca
uredi
Dužina polipeptidnog lanca je 1.297 aminokiselina , а molekulska težina 143.702 Da .[ 9]
10 20 30 40 50
MGRSGKLPSG VSAKLKRWKK GHSSDSNPAI CRHRQAARSR FFSRPSGRSD
LTVDAVKLHN ELQSGSLRLG KSEAPETPME EEAELVLTEK SSGTFLSGLS
DCTNVTFSKV QRFWESNSAA HKEICAVLAA VTEVIRSQGG KETETEYFAA
LMTTMEAVES PESLAAVAYL LNLVLKRVPS PVLIKKFSDT SKAFMDIMSA
QASSGSTSVL RWVLSCLATL LRKQDLEAWG YPVTLQVYHG LLSFTVHPKP
KIRKAAQHGV CSVLKGSEFM FEKAPAHHPA AISTAKFCIQ EIEKSGGSKE
ATTTLHMLTL LKDLLPCFPE GLVKSCSETL LRVMTLSHVL VTACAMQAFH
SLFHARPGLS TLSAELNAQI ITALYDYVPS ENDLQPLLAW LKVMEKAHIN
LVRLQWDLGL GHLPRFFGTA VTCLLSPHSQ VLTAATQSLK EILKECVAPH
MADIGSVTSS ASGPAQSVAK MFRAVEEGLT YKFHAAWSSV LQLLCVFFEA
CGRQAHPVMR KCLQSLCDLR LSPHFPHTAA LDQAVGAAVT SMGPEVVLQA
VPLEIDGSEE TLDFPRSWLL PVIRDHVQET RLGFFTTYFL PLANTLKSKA
MDLAQAGSTV ESKIYDTLQW QMWTLLPGFC TRPTDVAISF KGLARTLGMA
ISERPDLRVT VCQALRTLIT KGCQAEADRA EVSRFAKNFL PILFNLYGQP
VAAGDTPAPR RAVLETIRTY LTITDTQLVN SLLEKASEKV LDPASSDFTR
LSVLDLVVAL APCADEAAIS KLYSTIRPYL ESKAHGVQKK AYRVLEEVCA
SPQGPGALFV QSHLEDLKKT LLDSLRSTSS PAKRPRLKCL LHIVRKLSAE
HKEFITALIP EVILCTKEVS VGARKNAFAL LVEMGHAFLR FGSNQEEALQ
CYLVLIYPGL VGAVTMVSCS ILALTHLLFE FKGLMGTSTV EQLLENVCLL
LASRTRDVVK SALGFIKVAV TVMDVAHLAK HVQLVMEAIG KLSDDMRRHF
RMKLRNLFTK FIRKFGFELV KRLLPEEYHR VLVNIRKAEA RAKRHRALSQ
AAVEEEEEEE EEEEPAQGKG DSIEEILADS EDEEDNEEEE RSRGKEQRKL
ARQRSRAWLK EGGGDEPLNF LDPKVAQRVL ATQPGPGRGR KKDHGFKVSA
DGRLIIREEA DGNKMEEEEG AKGEDEEMAD PMEDVIIRNK KHQKLKHQKE
AEEEELEIPP QYQAGGSGIH RPVAKKAMPG AEYKAKKAKG DVKKKGRPDP
YAYIPLNRSK LNRRKKMKLQ GQFKGLVKAA RRGSQVGHKN RRKDRRP
^ a b c GRCh38: Ensembl release 89: ENSG00000052749 - Ensembl , maj 2017
^ a b c GRCm38: Ensembl release 89: ENSMUSG00000035049 - Ensembl , maj 2017
^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^ Ishikawa K, Nagase T, Suyama M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (juni 1998). "Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro" . DNA Research . 5 (3): 169–76. doi :10.1093/dnares/5.3.169 . PMID 9734811 .
^ "Entrez Gene: RRP12 ribosomal RNA processing 12 homolog (S. cerevisiae)" .
^ Oeffinger M, Dlakic M, Tollervey D (januar 2004). "A pre-ribosome-associated HEAT-repeat protein is required for export of both ribosomal subunits" . Genes & Development (jezik: engleski). 18 (2): 196–209. doi :10.1101/gad.285604 . PMC 324425 . PMID 14729571 .
^ Moriggi G, Nieto B, Dosil M (decembar 2014). "Rrp12 and the Exportin Crm1 participate in late assembly events in the nucleolus during 40S ribosomal subunit biogenesis" . PLOS Genetics . 10 (12): e1004836. doi :10.1371/journal.pgen.1004836 . PMC 4256259 . PMID 25474739 .
^ "UniProt, Q5JTH9" . Pristupljeno 4. 9. 2021 .
Dopunska literatura
uredi
Andersen JS, Lyon CE, Fox AH, Leung AK, Lam YW, Steen H, Mann M, Lamond AI (januar 2002). "Directed proteomic analysis of the human nucleolus" . Current Biology . 12 (1): 1–11. doi :10.1016/S0960-9822(01)00650-9 . PMID 11790298 .
Nakayama M, Kikuno R, Ohara O (novembar 2002). "Protein-protein interactions between large proteins: two-hybrid screening using a functionally classified library composed of long cDNAs" . Genome Research . 12 (11): 1773–84. doi :10.1101/gr.406902 . PMC 187542 . PMID 12421765 .
Scherl A, Couté Y, Déon C, Callé A, Kindbeiter K, Sanchez JC, Greco A, Hochstrasser D, Diaz JJ (novembar 2002). "Functional proteomic analysis of human nucleolus" . Molecular Biology of the Cell . 13 (11): 4100–9. doi :10.1091/mbc.E02-05-0271 . PMC 133617 . PMID 12429849 .
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Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Villén J, Li J, Cohn MA, Cantley LC, Gygi SP (august 2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins" . Proceedings of the National Academy of Sciences of the United States of America . 101 (33): 12130–5. doi :10.1073/pnas.0404720101 . PMC 514446 . PMID 15302935 .
Andersen JS, Lam YW, Leung AK, Ong SE, Lyon CE, Lamond AI, Mann M (januar 2005). "Nucleolar proteome dynamics". Nature . 433 (7021): 77–83. doi :10.1038/nature03207 . PMID 15635413 . S2CID 4344740 .
Nousiainen M, Silljé HH, Sauer G, Nigg EA, Körner R (april 2006). "Phosphoproteome analysis of the human mitotic spindle" . Proceedings of the National Academy of Sciences of the United States of America . 103 (14): 5391–6. doi :10.1073/pnas.0507066103 . PMC 1459365 . PMID 16565220 .
Beausoleil SA, Villén J, Gerber SA, Rush J, Gygi SP (oktobar 2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization" . Nature Biotechnology . 24 (10): 1285–92. doi :10.1038/nbt1240 . PMID 16964243 . S2CID 14294292 .
Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M (novembar 2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks" . Cell . 127 (3): 635–48. doi :10.1016/j.cell.2006.09.026 . PMID 17081983 .
Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry" . Molecular Systems Biology . 3 (1): 89. doi :10.1038/msb4100134 . PMC 1847948 . PMID 17353931 .