Homolog A proteina 1 prerade ribosomske RNK jest protein koji je kod ljudi kodiran genom RRP1 sa hromosoma 21.[3][4][5]

RRP1
Identifikatori
AliasiRRP1
Vanjski ID-jeviOMIM: 610653 HomoloGene: 90906 GeneCards: RRP1
Lokacija gena (čovjek)
Hromosom 21 (čovjek)
Hrom.Hromosom 21 (čovjek)[1]
Hromosom 21 (čovjek)
Genomska lokacija za RRP1
Genomska lokacija za RRP1
Bend21q22.3Početak43,789,513 bp[1]
Kraj43,805,293 bp[1]
Obrazac RNK ekspresije
Više referentnih podataka o ekspresiji
Ontologija gena
Molekularna funkcija vezivanje sa RNK
GO:0001948, GO:0016582 vezivanje za proteine
Ćelijska komponenta jedro
Jedarce
preribosome, small subunit precursor
preribosome, large subunit precursor
Biološki proces rRNA processing
Izvori:Amigo / QuickGO
Ortolozi
VrsteČovjekMiš
Entrez
Ensembl
UniProt
RefSeq (mRNK)

NM_003683

n/a

RefSeq (bjelančevina)

NP_003674

n/a

Lokacija (UCSC)Chr 21: 43.79 – 43.81 Mbn/a
PubMed pretraga[2]n/a
Wikipodaci
Pogledaj/uredi – čovjek

Aminokiselinska sekvenca uredi

Dužina polipeptidnog lanca je 461 aminokiselina, a molekulska težina 52.839 Da.[5]

1020304050
MVSRVQLPPEIQLAQRLAGNEQVTRDRAVRKLRKYIVARTQRAAGGFTHD
ELLKVWKGLFYCMWMQDKPLLQEELGRTISQLVHAFQTTEAQHLFLQAFW
QTMNREWTGIDRLRLDKFYMLMRMVLNESLKVLKMQGWEERQIEELLELL
MTEILHPSSQAPNGVKSHFIEIFLEELTKVGAEELTADQNLKFIDPFCRI
AARTKDSLVLNNITRGIFETIVEQAPLAIEDLLNELDTQDEEVASDSDES
SEGGERGDALSQKRSEKPPAGSICRAEPEAGEEQAGDDRDSGGPVLQFDY
EAVANRLFEMASRQSTPSQNRKRLYKVIRKLQDLAGGIFPEDEIPEKACR
RLLEGRRQKKTKKQKRLLRLQQERGKGEKEPPSPGMERKRSRRRGVGADP
EARAEAGEQPGTAERALLRDQPRGRGQRGARQRRRTPRPLTSARAKAANV
QEPEKKKKRRE

Funkcija uredi

Protein kodiran ovim genom je pretpostavljeni homolog kvašćčeve ribosomske RNK koji obrađuje protein RRP1. Kodirani protein je uključen u kasne faze nukleologeneze na kraju mitoza i može biti potreban za stvaranje 28S rRNK.[5]

Reference uredi

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000160214 - Ensembl, maj 2017
  2. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. ^ Hattori M, Fujiyama A, Taylor TD, Watanabe H, Yada T, Park HS, Toyoda A, Ishii K, Totoki Y, Choi DK, Groner Y, Soeda E, Ohki M, Takagi T, Sakaki Y, Taudien S, Blechschmidt K, Polley A, Menzel U, Delabar J, Kumpf K, Lehmann R, Patterson D, Reichwald K, Rump A, Schillhabel M, Schudy A, Zimmermann W, Rosenthal A, Kudoh J, Schibuya K, Kawasaki K, Asakawa S, Shintani A, Sasaki T, Nagamine K, Mitsuyama S, Antonarakis SE, Minoshima S, Shimizu N, Nordsiek G, Hornischer K, Brant P, Scharfe M, Schon O, Desario A, Reichelt J, Kauer G, Blocker H, Ramser J, Beck A, Klages S, Hennig S, Riesselmann L, Dagand E, Haaf T, Wehrmeyer S, Borzym K, Gardiner K, Nizetic D, Francis F, Lehrach H, Reinhardt R, Yaspo ML (Jun 2000). "The DNA sequence of human chromosome 21". Nature. 405 (6784): 311–9. Bibcode:2000Natur.405..311H. doi:10.1038/35012518. PMID 10830953.
  4. ^ Savino TM, Bastos R, Jansen E, Hernandez-Verdun D (Aug 1999). "The nucleolar antigen Nop52, the human homologue of the yeast ribosomal RNA processing RRP1, is recruited at late stages of nucleologenesis". J Cell Sci. 112. ( Pt 12) (12): 1889–900. doi:10.1242/jcs.112.12.1889. PMID 10341208.
  5. ^ a b c "Entrez Gene: D21S2056E DNA segment on chromosome 21 (unique) 2056 expressed sequence".

Dopunska literatura uredi