RNF11

RNF11
Identifikatori
Aliasi	RNF11
Vanjski ID-jevi	OMIM: 612598 MGI: 1352759 HomoloGene: 32195 GeneCards: RNF11
Lokacija gena (čovjek)
Hrom.	Hromosom 1 (čovjek)
Kraj	51,273,447 bp
Lokacija gena (miš)
Hrom.	Hromosom 4 (miš)
Kraj	109,341,925 bp
Obrazac RNK ekspresije
	Više referentnih podataka o ekspresiji
Ontologija gena
Molekularna funkcija	• vezivanje sa DNK; • GO:0001948, GO:0016582 vezivanje za proteine; • vezivanje iona metala; • GO:0050372 aktivnost sa transferazom ubikvitina; • GO:1904264, GO:1904822, GO:0090622, GO:0090302 ubiquitin protein ligase activity; • vezivanje iona cinka;
Ćelijska komponenta	• kompleks ubikvitin-ligaze; • citoplazma; • reciklirajući endosom; • endozom; • early endosome; • Egzosom; • jedro;
Biološki proces	• ubiquitin-dependent protein catabolic process; • protein autoubiquitination; • proteasome-mediated ubiquitin-dependent protein catabolic process;
	Izvori:Amigo / QuickGO
Ortolozi
	26994
	29864
	ENSG00000123091
	ENSMUSG00000028557
	Q9Y3C5
	Q9QYK7
	NM_014372
	NM_013876
	NP_055187
	NP_038904
	Wikipodaci
Pogledaj/uredi – čovjek	Pogledaj/uredi – miš

Protein 11 RING-prsta jest protein koji je kod ljudi kodiran genom RNF11 sa hromosoma 1.^[5]^[6]^[7]

Aminokiselinska sekvenca uredi

Dužina polipeptidnog lanca je 154 aminokiseline, a molekulska težina 17.444 Da.^[8]

C: Cistein

D: Asparaginska kiselina

E: Glutaminska kiselina

F: Fenilalanin

G: Glicin

H: Histidin

I: Izoleucin

K: Lizin

L: Leucin

M: Metionin

N: Asparagin

P: Prolin

Q: Glutamin

R: Arginin

S: Serin

T: Treonin

V: Valin

W: Triptofan

Y: Tirozin

10	20	30	40	50
MGNCLKSPTS	DDISLLHESQ	SDRASFGEGT	EPDQEPPPPY	QEQVPVPVYH
PTPSQTRLAT	QLTEEEQIRI	AQRIGLIQHL	PKGVYDPGRD	GSEKKIRECV
ICMMDFVYGD	PIRFLPCMHI	YHLDCIDDWL	MRSFTCPSCM	EPVDAALLSS
YETN

Funkcija uredi

Protein kodiran ovim genom sadrži motiv prsta RING-H2, za koji se zna da je važan za interakcije protein-protein. Pokazalo se da je ekspresija ovog gena indukovana mutantnim RET proteinima (MEN2A/MEN2B). Poznato je da su mutacije zametne linije u genu RET odgovorne za razvoj višestruke endokrine neoplazije (MEN).^[7]

Interakcije uredi

Pokazalo se da RNF11 raguje sa RIPK1^[9] i STAMBP.^[10]

Također pogledajte uredi

Domen RING-prsta

Reference uredi

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000123091 - Ensembl, maj 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000028557 - Ensembl, maj 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Seki N, Hattori A, Hayashi A, Kozuma S, Sasaki M, Suzuki Y, Sugano S, Muramatsu MA, Saito T (decembar 1999). "Cloning and expression profile of mouse and human genes, Rnf11/RNF11, encoding a novel RING-H2 finger protein". Biochim. Biophys. Acta. 1489 (2–3): 421–7. doi:10.1016/s0167-4781(99)00190-6. PMID 10673045.
^ Lai CH, Chou CY, Ch'ang LY, Liu CS, Lin W (august 2000). "Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics". Genome Res. 10 (5): 703–13. doi:10.1101/gr.10.5.703. PMC 310876. PMID 10810093.
^ ^a ^b "Entrez Gene: RNF11 ring finger protein 11".
^ "UniProt, Q9Y3C5" (jezik: eng.). Pristupljeno 4. 12. 2021.CS1 održavanje: nepoznati jezik (link)
^ Shembade N, Parvatiyar K, Harhaj NS, Harhaj EW (mart 2009). "The ubiquitin-editing enzyme A20 requires RNF11 to downregulate NF-kappaB signalling". EMBO J. 28 (5): 513–22. doi:10.1038/emboj.2008.285. PMC 2657574. PMID 19131965.
^ Li H, Seth A (mart 2004). "An RNF11: Smurf2 complex mediates ubiquitination of the AMSH protein". Oncogene. 23 (10): 1801–8. doi:10.1038/sj.onc.1207319. PMID 14755250.

Dopunska literatura uredi

Burger A, Amemiya Y, Kitching R, Seth AK (2006). "Novel RING E3 ubiquitin ligases in breast cancer". Neoplasia. 8 (8): 689–95. doi:10.1593/neo.06469. PMC 1601945. PMID 16925951.
Jolliffe CN, Harvey KF, Haines BP, Parasivam G, Kumar S (2000). "Identification of multiple proteins expressed in murine embryos as binding partners for the WW domains of the ubiquitin-protein ligase Nedd4". Biochem. J. 351 Pt 3 (3): 557–65. doi:10.1042/0264-6021:3510557. PMC 1221394. PMID 11042109.
Watanabe T, Ichihara M, Hashimoto M, Shimono K, Shimoyama Y, Nagasaka T, Murakumo Y, Murakami H, Sugiura H, Iwata H, Ishiguro N, Takahashi M (2002). "Characterization of gene expression induced by RET with MEN2A or MEN2B mutation". Am. J. Pathol. 161 (1): 249–56. doi:10.1016/S0002-9440(10)64176-4. PMC 1850689. PMID 12107109.
Kitching R, Wong MJ, Koehler D, Burger AM, Landberg G, Gish G, Seth A (2003). "The RING-H2 protein RNF11 is differentially expressed in breast tumours and interacts with HECT-type E3 ligases". Biochim. Biophys. Acta. 1639 (2): 104–12. doi:10.1016/j.bbadis.2003.07.001. PMID 14559117.
Subramaniam V, Li H, Wong M, Kitching R, Attisano L, Wrana J, Zubovits J, Burger AM, Seth A (2003). "The RING-H2 protein RNF11 is overexpressed in breast cancer and is a target of Smurf2 E3 ligase". Br. J. Cancer. 89 (8): 1538–44. doi:10.1038/sj.bjc.6601301. PMC 2394340. PMID 14562029.
Li H, Seth A (2004). "An RNF11: Smurf2 complex mediates ubiquitination of the AMSH protein". Oncogene. 23 (10): 1801–8. doi:10.1038/sj.onc.1207319. PMID 14755250.
Colland F, Jacq X, Trouplin V, Mougin C, Groizeleau C, Hamburger A, Meil A, Wojcik J, Legrain P, Gauthier JM (2004). "Functional proteomics mapping of a human signaling pathway". Genome Res. 14 (7): 1324–32. doi:10.1101/gr.2334104. PMC 442148. PMID 15231748.
Connor MK, Azmi PB, Subramaniam V, Li H, Seth A (2005). "Molecular characterization of ring finger protein 11". Mol. Cancer Res. 3 (8): 453–61. doi:10.1158/1541-7786.MCR-04-0166. PMID 16123141.
Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
Kimura K, Wakamatsu A, Suzuki Y, Ota T, Nishikawa T, Yamashita R, Yamamoto J, Sekine M, Tsuritani K, Wakaguri H, Ishii S, Sugiyama T, Saito K, Isono Y, Irie R, Kushida N, Yoneyama T, Otsuka R, Kanda K, Yokoi T, Kondo H, Wagatsuma M, Murakawa K, Ishida S, Ishibashi T, Takahashi-Fujii A, Tanase T, Nagai K, Kikuchi H, Nakai K, Isogai T, Sugano S (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
Anderson LR, Betarbet R, Gearing M, Gulcher J, Hicks AA, Stefánsson K, Lah JJ, Levey AI (2007). "PARK10 candidate RNF11 is expressed by vulnerable neurons and localizes to Lewy bodies in Parkinson disease brain". J. Neuropathol. Exp. Neurol. 66 (10): 955–64. doi:10.1097/nen.0b013e3181567f17. PMID 17917589.

Vanjski linkovi uredi

RNF11 protein, human na US National Library of Medicine Medical Subject Headings (MeSH)

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000123091 - Ensembl, maj 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000028557 - Ensembl, maj 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10673045-5] Seki N, Hattori A, Hayashi A, Kozuma S, Sasaki M, Suzuki Y, Sugano S, Muramatsu MA, Saito T (decembar 1999). "Cloning and expression profile of mouse and human genes, Rnf11/RNF11, encoding a novel RING-H2 finger protein". Biochim. Biophys. Acta. 1489 (2–3): 421–7. doi:10.1016/s0167-4781(99)00190-6. PMID 10673045.

[pmid10810093-6] Lai CH, Chou CY, Ch'ang LY, Liu CS, Lin W (august 2000). "Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics". Genome Res. 10 (5): 703–13. doi:10.1101/gr.10.5.703. PMC 310876. PMID 10810093.

[entrez-7] "Entrez Gene: RNF11 ring finger protein 11".

[UniProt-8] "UniProt, Q9Y3C5" (jezik: eng.). Pristupljeno 4. 12. 2021.CS1 održavanje: nepoznati jezik (link)

[pmid19131965-9] Shembade N, Parvatiyar K, Harhaj NS, Harhaj EW (mart 2009). "The ubiquitin-editing enzyme A20 requires RNF11 to downregulate NF-kappaB signalling". EMBO J. 28 (5): 513–22. doi:10.1038/emboj.2008.285. PMC 2657574. PMID 19131965.

[pmid14755250-10] Li H, Seth A (mart 2004). "An RNF11: Smurf2 complex mediates ubiquitination of the AMSH protein". Oncogene. 23 (10): 1801–8. doi:10.1038/sj.onc.1207319. PMID 14755250.

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