RNK-egzonukleaza 4 je enzim koji je kod ljudi kodiran genom REXO4.[5][6]

REXO4
Identifikatori
AliasiREXO4
Vanjski ID-jeviOMIM: 602930 MGI: 2684957 HomoloGene: 133948 GeneCards: REXO4
Lokacija gena (čovjek)
Hromosom 9 (čovjek)
Hrom.Hromosom 9 (čovjek)[1]
Hromosom 9 (čovjek)
Genomska lokacija za REXO4
Genomska lokacija za REXO4
Bend9q34.2Početak133,406,059 bp[1]
Kraj133,418,096 bp[1]
Lokacija gena (miš)
Hromosom 2 (miš)
Hrom.Hromosom 2 (miš)[2]
Hromosom 2 (miš)
Genomska lokacija za REXO4
Genomska lokacija za REXO4
Bend2|2 A3Početak26,843,575 bp[2]
Kraj26,854,398 bp[2]
Obrazac RNK ekspresije
Više referentnih podataka o ekspresiji
Ontologija gena
Molekularna funkcija GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity
nuclease activity
exonuclease activity
hydrolase activity
nucleic acid binding
vezivanje sa RNK
single-stranded DNA binding
GO:0001105 transcription coactivator activity
endonuclease activity
3'-5' exonuclease activity
Ćelijska komponenta Jedarce
jedro
nuclear speck
Biološki proces GO:0009373 regulation of transcription, DNA-templated
nucleic acid phosphodiester bond hydrolysis
DNA catabolic process, endonucleolytic
DNA catabolic process, exonucleolytic
rRNA processing
GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II
Izvori:Amigo / QuickGO
Ortolozi
VrsteČovjekMiš
Entrez
Ensembl
UniProt
RefSeq (mRNK)

NM_001279349
NM_001279350
NM_001279351
NM_020385

NM_207234
NM_001362876

RefSeq (bjelančevina)

NP_001266278
NP_001266279
NP_001266280
NP_065118

NP_997117
NP_001349805

Lokacija (UCSC)Chr 9: 133.41 – 133.42 MbChr 2: 26.84 – 26.85 Mb
PubMed pretraga[3][4]
Wikipodaci
Pogledaj/uredi – čovjekPogledaj/uredi – miš

Aminokiselinska sekvenca

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Dužina polipeptidnog lanca je 422 aminokiseline, а molekulska težina 46.672 Da.[7]

1020304050
MGKAKVPASKRAPSSPVAKPGPVKTLTRKKNKKKKRFWKSKAREVSKKPA
SGPGAVVRPPKAPEDFSQNWKALQEWLLKQKSQAPEKPLVISQMGSKKKP
KIIQQNKKETSPQVKGEEMPAGKDQEASRGSVPSGSKMDRRAPVPRTKAS
GTEHNKKGTKERTNGDIVPERGDIEHKKRKAKEAAPAPPTEEDIWFDDVD
PADIEAAIGPEAAKIARKQLGQSEGSVSLSLVKEQAFGGLTRALALDCEM
VGVGPKGEESMAARVSIVNQYGKCVYDKYVKPTEPVTDYRTAVSGIRPEN
LKQGEELEVVQKEVAEMLKGRILVGHALHNDLKVLFLDHPKKKIRDTQKY
KPFKSQVKSGRPSLRLLSEKILGLQVQQAEHCSIQDAQAAMRLYVMVKKE
WESMARDRRPLLTAPDHCSDDA

Reference

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  1. ^ a b c ENSG00000148300 GRCh38: Ensembl release 89: ENSG00000280706, ENSG00000148300 - Ensembl, maj 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000052406 - Ensembl, maj 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Kwiatkowska J, Slomski R, Jozwiak S, Short MP, Kwiatkowski DJ (Nov 1997). "Human XPMC2H: cDNA cloning, mapping to 9q34, genomic structure, and evaluation as TSC1". Genomics. 44 (3): 350–4. doi:10.1006/geno.1997.4874. PMID 9325058.
  6. ^ "Entrez Gene: REXO4 REX4, RNA exonuclease 4 homolog (S. cerevisiae)".
  7. ^ "UniProt, Q9GZR2". Pristupljeno 11. 9. 2021.

Dopunska literatura

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Vanjski linkovi

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