RCBTB2
RCC1 i BTB protein 2 sa domenom je protein koji je kod ljudi kodiran genom RCBTB2.[5][6]
Ovaj gen kodira člana porodice GEF, povezane sa RCC1. N-terminalna polovina kodirane aminokiselinske sekvence pokazuje sličnost s regulatorom kondenzacije hromosoma RCC1, koji djeluje kao faktor izmjene guaninskih nukleotida (GEF) za Ras srodnu GTPazu Ran.[6]
Aminokiselinska sekvenca
urediDužina polipeptidnog lanca je 551 aminokiselina, a molekulska težina 60.315 Da.[7].
| 10 | 20 | 30 | 40 | 50 | ||||
|---|---|---|---|---|---|---|---|---|
| MEEELPLFSG | DSGKPVQATL | SSLKMLDVGK | WPIFSLCSEE | ELQLIRQACV | ||||
| FGSAGNEVLY | TTVNDEIFVL | GTNCCGCLGL | GDVQSTIEPR | RLDSLNGKKI | ||||
| ACLSYGSGPH | IVLATTEGEV | FTWGHNAYSQ | LGNGTTNHGL | VPCHISTNLS | ||||
| NKQVIEVACG | SYHSLVLTSD | GEVFAWGYNN | SGQVGSGSTV | NQPIPRRVTG | ||||
| CLQNKVVVTI | ACGQMCCMAV | VDTGEVYVWG | YNGNGQLGLG | NSGNQPTPCR | ||||
| VAALQGIRVQ | RVACGYAHTL | VLTDEGQVYA | WGANSYGQLG | TGNKSNQSYP | ||||
| TPVTVEKDRI | IEIAACHSTH | TSAAKTQGGH | VYMWGQCRGQ | SVILPHLTHF | ||||
| SCTDDVFACF | ATPAVTWRLL | SVEPDDHLTV | AESLKREFDN | PDTADLKFLV | ||||
| DGKYIYAHKV | LLKIRCEHFR | SSLEDNEDDI | VEMSEFSYPV | YRAFLEYLYT | ||||
| DSISLSPEEA | VGLLDLATFY | RENRLKKLCQ | QTIKQGICEE | NAIALLSAAV | ||||
| KYDAQDLEEF | CFRFCINHLT | VVTQTSGFAE | MDHDLLKNFI | SKASRVGAFK | ||||
| N |
- Simboli
Reference
uredi- ^ a b c GRCh38: Ensembl release 89: ENSG00000136161 - Ensembl, maj 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000022106 - Ensembl, maj 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Devilder MC, Cadoret E, Cherel M, Moreau I, Rondeau G, Bezieau S, Moisan JP (Jan 1999). "cDNA cloning, gene characterization and 13q14.3 chromosomal assignment of CHC1-L, a chromosome condensation regulator-like guanine nucleotide exchange factor". Genomics. 54 (1): 99–106. doi:10.1006/geno.1998.5498. PMID 9806834.
- ^ a b "Entrez Gene: RCBTB2 regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2".
- ^ "UniProt, O95199". Pristupljeno 4. 8. 2021.
Dopunska literatura
uredi- Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Dunham A, Matthews LH, Burton J, et al. (2004). "The DNA sequence and analysis of human chromosome 13". Nature. 428 (6982): 522–8. doi:10.1038/nature02379. PMC 2665288. PMID 15057823.
- Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Latil A, Morant P, Fournier G, et al. (2002). "CHC1-L, a candidate gene for prostate carcinogenesis at 13q14.2, is frequently affected by loss of heterozygosity and underexpressed in human prostate cancer". Int. J. Cancer. 99 (5): 689–96. doi:10.1002/ijc.10393. PMID 12115502.
- Renault L, Nassar N, Wittinghofer A, et al. (1999). "Crystallization and preliminary X-ray analysis of human RCC1, the regulator of chromosome condensation". Acta Crystallogr. D. 55 (Pt 1): 272–5. doi:10.1107/S0907444998007768. PMID 10089422.