RABIF
Guaninsko-nukleotidni razmjenski faktor MSS4 jest protein koji je kod ljudi kodiran genom RABIF sa hromosoma 1.[5][6][7]
Aminokiselinska sekvenca
urediDužina polipeptidnog lanca je 123 aminokiseline, a molekulska težina 13.839 Da.[8]
| 10 | 20 | 30 | 40 | 50 | ||||
|---|---|---|---|---|---|---|---|---|
| MEPAEQPSEL | VSAEGRNRKA | VLCQRCGSRV | LQPGTALFSR | RQLFLPSMRK | ||||
| KPALSDGSNP | DGDLLQEHWL | VEDMFIFENV | GFTKDVGNIK | FLVCADCEIG | ||||
| PIGWHCLDDK | NSFYVALERV | SHE |
Funkcija
urediMali GTP-vezujući proteini, povezani sa Sec4/Rab, uključeni su u regulaciju unutarćelijskog vezikulskog transporta. Mss4 stimulira razmjenu GTP-GDP u Sec4 i Rab i veže se za podskup genetički srodnih Rab proteina.[7]
Reference
uredi- ^ a b c GRCh38: Ensembl release 89: ENSG00000183155 - Ensembl, maj 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000042229 - Ensembl, maj 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Müller-Pillasch F, Zimmerhackl F, Lacher U, Schultz N, Hameister H, Varga G, Friess H, Büchler M, Adler G, Gress TM (Mar 1998). "Cloning of novel transcripts of the human guanine-nucleotide-exchange factor Mss4: in situ chromosomal mapping and expression in pancreatic cancer". Genomics. 46 (3): 389–96. doi:10.1006/geno.1997.5049. PMID 9441742.
- ^ Yu H, Schreiber SL (Aug 1995). "Cloning, Zn2+ binding, and structural characterization of the guanine nucleotide exchange factor human Mss4". Biochemistry. 34 (28): 9103–10. CiteSeerX 10.1.1.540.2153. doi:10.1021/bi00028a020. PMID 7619808.
- ^ a b "Entrez Gene: RABIF RAB interacting factor".
- ^ "UniProt, P47224" (jezik: engleski). Pristupljeno 17. 12. 2021.
Dopunska literatura
uredi- Yu H, Schreiber SL (1995). "Structure of guanine-nucleotide-exchange factor human Mss4 and identification of its Rab-interacting surface". Nature. 376 (6543): 788–91. Bibcode:1995Natur.376..788Y. doi:10.1038/376788a0. PMID 7651540. S2CID 4368525.
- Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
- Burton JL, Slepnev V, De Camilli PV (1997). "An evolutionarily conserved domain in a subfamily of Rabs is crucial for the interaction with the guanyl nucleotide exchange factor Mss4". J. Biol. Chem. 272 (6): 3663–8. doi:10.1074/jbc.272.6.3663. PMID 9013620.
- Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
- Wixler V, Laplantine E, Geerts D, Sonnenberg A, Petersohn D, Eckes B, Paulsson M, Aumailley M (1999). "Identification of novel interaction partners for the conserved membrane proximal region of alpha-integrin cytoplasmic domains". FEBS Lett. 445 (2–3): 351–5. doi:10.1016/S0014-5793(99)00151-9. PMID 10094488.
- Strick DJ, Francescutti DM, Zhao Y, Elferink LA (2002). "Mammalian suppressor of Sec4 modulates the inhibitory effect of Rab15 during early endocytosis". J. Biol. Chem. 277 (36): 32722–9. doi:10.1074/jbc.M205101200. PMID 12105226.
- Stelzl U, Worm U, Lalowski M, Haenig C, Brembeck FH, Goehler H, Stroedicke M, Zenkner M, Schoenherr A, Koeppen S, Timm J, Mintzlaff S, Abraham C, Bock N, Kietzmann S, Goedde A, Toksöz E, Droege A, Krobitsch S, Korn B, Birchmeier W, Lehrach H, Wanker EE (2005). "A human protein-protein interaction network: a resource for annotating the proteome". Cell. 122 (6): 957–68. doi:10.1016/j.cell.2005.08.029. hdl:11858/00-001M-0000-0010-8592-0. PMID 16169070. S2CID 8235923.