PTPRCAP

Receptorski tip C-pridruženog proteina tirozin-fosfataze je enzim koji je kod ljudi kodiran genom PTPRCAP.

PTPRCAP
Identifikatori
Aliasi	PTPRCAP
Vanjski ID-jevi	OMIM: 601577 MGI: 97811 HomoloGene: 48358 GeneCards: PTPRCAP
Lokacija gena (čovjek) Hrom. Hromosom 11 (čovjek) Bend 11q13.2 Početak 67,435,510 bp Kraj 67,437,682 bp
Lokacija gena (miš) Hrom. Hromosom 19 (miš) Bend 19 A|19 3.86 cM Početak 4,203,603 bp Kraj 4,206,750 bp
Ortolozi
Vrste	Čovjek	Miš
Entrez	5790	19265
Ensembl	ENSG00000213402	ENSMUSG00000045826
UniProt	Q14761	Q64697
RefSeq (mRNK)	NM_005608	NM_016933
RefSeq (bjelančevina)	NP_005599	NP_058629
Lokacija (UCSC)	Chr 11: 67.44 – 67.44 Mb	Chr 19: 4.2 – 4.21 Mb
PubMed pretraga
Wikipodaci
Pogledaj/uredi – čovjek Pogledaj/uredi – miš

Protein kodiran ovim genom identificiran je kao transmembranski fosfoprotein specifično povezan s tirozin-fosfatazom PTPRC/CD45, ključnim regulatorom aktivacije T– i B-limfocita. Za stabilnu ekspresiju ovog proteina može biti potrebna interakcija s PTPRC.

Aminokiselinska sekvenca

Dužina polipeptidnog lanca je 206 aminokiselina, a molekulska težina 21.196 Da.

10		20		30		40		50
MALPCTLGLG		MLLALPGALG		SGGSAEDSVG		SSSVTVVLLL		LLLLLLATGL
ALAWRRLSRD		SGGYYHPARL		GAALWGRTRR		LLWASPPGRW		LQARAELGST
DNDLERQEDE		QDTDYDHVAD		GGLQADPGEG		EQQCGEASSP		EQVPVRAEEA
RDSDTEGDLV		LGSPGPASAG		GSAEALLSDL		HAFAGSAAWD		DSARAAGGQG
LHVTAL

• C: Cistein
• D: Asparaginska kiselina
• E: Glutaminska kiselina
• F: Fenilalanin
• G: Glicin
• H: Histidin
• I: Izoleucin
• K: Lizin
• L: Leucin
• M: Metionin
• N: Asparagin
• P: Prolin
• Q: Glutamin
• R: Arginin
• S: Serin
• T: Treonin
• V: Valin
• W: Triptofan
• Y: Tirozin

Dopunska literatura

• Schraven B, Schoenhaut D, Bruyns E, et al. (1994). "LPAP, a novel 32-kDa phosphoprotein that interacts with CD45 in human lymphocytes". J. Biol. Chem. 269 (46): 29102–11. PMID 7961877.
• Bruyns E, Hendricks-Taylor LR, Meuer S, et al. (1996). "Identification of the sites of interaction between lymphocyte phosphatase-associated phosphoprotein (LPAP) and CD45". J. Biol. Chem. 270 (52): 31372–6. doi:10.1074/jbc.270.52.31372. PMID 8537410.
• Bruyns E, Mincheva A, Bruyns RM, et al. (1997). "Sequence, genomic organization, and chromosomal localization of the human LPAP (PTPRCAP) and mouse CD45-AP/LSM-1 genes". Genomics. 38 (1): 79–83. doi:10.1006/geno.1996.0595. PMID 8954783.
• Kung C, Okumura M, Seavitt JR, et al. (2000). "CD45-associated protein is not essential for the regulation of antigen receptor-mediated signal transduction". Eur. J. Immunol. 29 (12): 3951–5. doi:10.1002/(SICI)1521-4141(199912)29:12<3951::AID-IMMU3951>3.0.CO;2-9. PMID 10602003.
• Woods ML, Kivens WJ, Adelsman MA, et al. (2001). "A novel function for the Tec family tyrosine kinase Itk in activation of β1 integrins by the T-cell receptor". EMBO J. 20 (6): 1232–44. doi:10.1093/emboj/20.6.1232. PMC 145515. PMID 11250890.
• Kirchgessner H, Dietrich J, Scherer J, et al. (2001). "The Transmembrane Adaptor Protein Trim Regulates T Cell Receptor (Tcr) Expression and Tcr-Mediated Signaling via an Association with the Tcr ζ Chain". J. Exp. Med. 193 (11): 1269–84. doi:10.1084/jem.193.11.1269. PMC 2193385. PMID 11390434.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Vogel A, Strassburg CP, Manns MP (2003). "77 C/G mutation in the tyrosine phosphatase CD45 gene and autoimmune hepatitis: evidence for a genetic link". Genes Immun. 4 (1): 79–81. doi:10.1038/sj.gene.6363918. PMID 12595907.
• Cocco E, Murru MR, Melis C, et al. (2004). "PTPRC (CD45) C77G mutation does not contribute to multiple sclerosis susceptibility in Sardinian patients". J. Neurol. 251 (9): 1085–8. doi:10.1007/s00415-004-0485-1. PMID 15372250. S2CID 35718298.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.