Polipeptidoliki proaktivator 1 jest protein koji je kod ljudi kodiran genom PSAPL1 sa hromosoma 4. Član je proteinske porodice sapozina. [5]

PSAPL1
Identifikatori
AliasiPSAPL1
Vanjski ID-jeviMGI: 1924193 HomoloGene: 105928 GeneCards: PSAPL1
Lokacija gena (čovjek)
Hromosom 4 (čovjek)
Hrom.Hromosom 4 (čovjek)[1]
Hromosom 4 (čovjek)
Genomska lokacija za PSAPL1
Genomska lokacija za PSAPL1
Bend4p16.1Početak7,430,285 bp[1]
Kraj7,434,930 bp[1]
Lokacija gena (miš)
Hromosom 5 (miš)
Hrom.Hromosom 5 (miš)[2]
Hromosom 5 (miš)
Genomska lokacija za PSAPL1
Genomska lokacija za PSAPL1
Bend5|5 B3Početak36,361,365 bp[2]
Kraj36,363,912 bp[2]
Ontologija gena
Molekularna funkcija GO:0010577 enzyme activator activity
G protein-coupled receptor binding
Ćelijska komponenta extracellular region
Lizozom
Vanćelijsko
citoplazma
citosol
Biološki proces regulation of lipid metabolic process
prostate gland growth
adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway
epithelial cell differentiation involved in prostate gland development
sphingolipid metabolic process
lipid metabolism
GO:0048554 positive regulation of catalytic activity
Izvori:Amigo / QuickGO
Ortolozi
VrsteČovjekMiš
Entrez
Ensembl
UniProt
RefSeq (mRNK)

NM_001085382

NM_175249

RefSeq (bjelančevina)

NP_001078851

NP_780458

Lokacija (UCSC)Chr 4: 7.43 – 7.43 MbChr 5: 36.36 – 36.36 Mb
PubMed pretraga[3][4]
Wikipodaci
Pogledaj/uredi – čovjekPogledaj/uredi – miš

Aminokiselinska sekvenca

uredi

Dužina polipeptidnog lanca je 521 aminokiselina, а molekulska težina 56.627 Da.[6]

1020304050
MLCALLLLPSLLGATRASPTSGPQECAKGSTVWCQDLQTAARCGAVGYCQ
GAVWNKPTAKSLPCDVCQDIAAAAGNGLNPDATESDILALVMKTCEWLPS
QESSAGCKWMVDAHSSAILSMLRGAPDSAPAQVCTALSLCEPLQRHLATL
RPLSKEDTFEAVAPFMANGPLTFHPRQAPEGALCQDCVRQVSRLQEAVRS
NLTLADLNIQEQCESLGPGLAVLCKNYLFQFFVPADQALRLLPPQELCRK
GGFCEELGAPARLTQVVAMDGVPSLELGLPRKQSEMQMKAGVTCEVCMNV
VQKLDHWLMSNSSELMITHALERVCSVMPASITKECIILVDTYSPSLVQL
VAKITPEKVCKFIRLCGNRRRARAVHDAYAIVPSPEWDAENQGSFCNGCK
RLLTVSSHNLESKSTKRDILVAFKGGCSILPLPYMIQCKHFVTQYEPVLI
ESLKDMMDPVAVCKKVGACHGPRTPLLGTDQCALGPSFWCRSQEAAKLCN
AVQHCQKHVWKEMHLHAGEHA

Reference

uredi
  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000178597 - Ensembl, maj 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000043430 - Ensembl, maj 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: Prosaposin-like 1 (gene/pseudogene)". Pristupljeno 11. 4. 2013.
  6. ^ "UniProt, Q6NUJ1" (jezik: eng). Pristupljeno 30. 10. 2021.CS1 održavanje: nepoznati jezik (link)