PROSC

Kotranskribirani bakterijski homologni protein prolin-sintetaza je protein/enzim koji je kod ljudi kodiran genom PROSC.

PROSC
Identifikatori
Aliasi	PLPBP
Vanjski ID-jevi	OMIM: 604436 MGI: 1891207 HomoloGene: 5211 GeneCards: PLPBP
Lokacija gena (miš) Hrom. Hromosom 8 (miš) Bend 8|8 A2 Početak 27,532,583 bp Kraj 27,546,160 bp
Obrazac RNK ekspresije Više referentnih podataka o ekspresiji
Ontologija gena Molekularna funkcija • pyridoxal phosphate binding Ćelijska komponenta • citoplazma • intracellular anatomical structure Biološki proces • GO:0022610 biološki proces Izvori:Amigo / QuickGO
Ortolozi
Vrste	Čovjek	Miš
Entrez	11212	114863
Ensembl	ENSG00000147471	ENSMUSG00000031485
UniProt	O94903	Q9Z2Y8
RefSeq (mRNK)	NM_007198	NM_001039077 NM_001039078 NM_054057 NM_001363479
RefSeq (bjelančevina)	NP_009129 NP_001336275 NP_001336276 NP_001336277 NP_001336278	NP_001034166 NP_001034167 NP_473398 NP_001350408
Lokacija (UCSC)	n/a	Chr 8: 27.53 – 27.55 Mb
PubMed pretraga
Wikipodaci
Pogledaj/uredi – čovjek Pogledaj/uredi – miš

Aminokiselinska sekvenca

Dužina polipeptidnog lanca je 275 aminokiselina, а molekulska težina 30.344 Da.

• C: Cistein
• D: Asparaginska kiselina
• E: Glutaminska kiselina
• F: Fenilalanin
• G: Glicin
• H: Histidin
• I: Izoleucin
• K: Lizin
• L: Leucin
• M: Metionin
• N: Asparagin
• P: Prolin
• Q: Glutamin
• R: Arginin
• S: Serin
• T: Treonin
• V: Valin
• W: Triptofan
• Y: Tirozin

10		20		30		40		50
MWRAGSMSAE		LGVGCALRAV		NERVQQAVAR		RPRDLPAIQP		RLVAVSKTKP
ADMVIEAYGH		GQRTFGENYV		QELLEKASNP		KILSLCPEIK		WHFIGHLQKQ
NVNKLMAVPN		LFMLETVDSV		KLADKVNSSW		QRKGSPERLK		VMVQINTSGE
ESKHGLPPSE		TIAIVEHINA		KCPNLEFVGL		MTIGSFGHDL		SQGPNPDFQL
LLSLREELCK		KLNIPADQVE		LSMGMSADFQ		HAVEVGSTNV		RIGSTIFGER
DYSKKPTPDK		CAADVKAPLE		VAQEH

Dopunska literatura

• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Simpson JC, Wellenreuther R, Poustka A, et al. (2001). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing". EMBO Rep. 1 (3): 287–92. doi:10.1093/embo-reports/kvd058. PMC 1083732. PMID 11256614.
• Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
• Ikegawa S, Isomura M, Koshizuka Y, Nakamura Y (1999). "Cloning and characterization of human and mouse PROSC (proline synthetase co-transcribed) genes". J. Hum. Genet. 44 (5): 337–42. doi:10.1007/s100380050172. PMID 10496079.
• Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.