PREPL

PREPL
Identifikatori
Aliasi	PREPL
Vanjski ID-jevi	OMIM: 609557 MGI: 2441932 HomoloGene: 15481 GeneCards: PREPL
Lokacija gena (čovjek)
Hrom.	Hromosom 2 (čovjek)
Kraj	44,361,862 bp
Lokacija gena (miš)
Hrom.	Hromosom 17 (miš)
Kraj	85,397,669 bp
Obrazac RNK ekspresije
	; ; ; ;
	Više referentnih podataka o ekspresiji
Ontologija gena
Molekularna funkcija	• serine-type exopeptidase activity; • GO:0070122 peptidase activity; • serine-type peptidase activity; • hydrolase activity; • serine-type endopeptidase activity; • GO:0001948, GO:0016582 vezivanje za proteine;
Ćelijska komponenta	• citoplazma; • citosol; • Golđijev aparat; • citoskelet;
Biološki proces	• Proteoliza; • regulation of synaptic vesicle exocytosis;
	Izvori:Amigo / QuickGO
Ortolozi
	9581
	213760
	ENSG00000138078
	ENSMUSG00000024127
	Q4J6C6
	Q8C167
NM_001042385; NM_001042386; NM_001171603; NM_001171606; NM_001171613;
	NM_001171617; NM_006036; NM_001374275; NM_001374276; NM_001374277
	NM_001163622; NM_001163623; NM_001163624; NM_145984
NP_001035844; NP_001035845; NP_001165074; NP_001165077; NP_001165084;
	NP_001165088; NP_006027; NP_001361204; NP_001361205; NP_001361206
	NP_001157094; NP_001157095; NP_001157096; NP_666096
	Wikipodaci
Pogledaj/uredi – čovjek	Pogledaj/uredi – miš

Prolil-endopeptidazoliki protein jest enzim koji je kod ljudi kodiran genom PREPL sa hromosoma 2.^[5]^[6]

Amiokiselininska sekvenca

Dužina polipeptidnog lanca je 727 aminokiselina, a molekulska težina 83.927 Da.^[7]

C: Cistein

D: Asparaginska kiselina

E: Glutaminska kiselina

F: Fenilalanin

G: Glicin

H: Histidin

I: Izoleucin

K: Lizin

L: Leucin

M: Metionin

N: Asparagin

P: Prolin

Q: Glutamin

R: Arginin

S: Serin

T: Treonin

V: Valin

W: Triptofan

Y: Tirozin

10	20	30	40	50
MQQKTKLFLQ	ALKYSIPHLG	KCMQKQHLNH	YNFADHCYNR	IKLKKYHLTK
CLQNKPKISE	LARNIPSRSF	SCKDLQPVKQ	ENEKPLPENM	DAFEKVRTKL
ETQPQEEYEI	INVEVKHGGF	VYYQEGCCLV	RSKDEEADND	NYEVLFNLEE
LKLDQPFIDC	IRVAPDEKYV	AAKIRTEDSE	ASTCVIIKLS	DQPVMEASFP
NVSSFEWVKD	EEDEDVLFYT	FQRNLRCHDV	YRATFGDNKR	NERFYTEKDP
SYFVFLYLTK	DSRFLTINIM	NKTTSEVWLI	DGLSPWDPPV	LIQKRIHGVL
YYVEHRDDEL	YILTNVGEPT	EFKLMRTAAD	TPAIMNWDLF	FTMKRNTKVI
DLDMFKDHCV	LFLKHSNLLY	VNVIGLADDS	VRSLKLPPWA	CGFIMDTNSD
PKNCPFQLCS	PIRPPKYYTY	KFAEGKLFEE	TGHEDPITKT	SRVLRLEAKS
KDGKLVPMTV	FHKTDSEDLQ	KKPLLVHVYG	AYGMDLKMNF	RPERRVLVDD
GWILAYCHVR	GGGELGLQWH	ADGRLTKKLN	GLADLEACIK	TLHGQGFSQP
SLTTLTAFSA	GGVLAGALCN	SNPELVRAVT	LEAPFLDVLN	TMMDTTLPLT
LEELEEWGNP	SSDEKHKNYI	KRYCPYQNIK	PQHYPSIHIT	AYENDERVPL
KGIVSYTEKL	KEAIAEHAKD	TGEGYQTPNI	ILDIQPGGNH	VIEDSHKKIT
AQIKFLYEEL	GLDSTSVFED	LKKYLKF

Funkcija

Prema OMIM-u, PREPL pripada potporodici proteina serinskih peptidaznih proliloligopeptidaza (Parvari et al., 2005).^[6]

Reference

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000138078 - Ensembl, maj 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000024127 - Ensembl, maj 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Parvari R, Brodyansky I, Elpeleg O, Moses S, Landau D, Hershkovitz E (Sep 2001). "A recessive contiguous gene deletion of chromosome 2p16 associated with cystinuria and a mitochondrial disease". Am J Hum Genet. 69 (4): 869–875. doi:10.1086/323624. PMC 1226072. PMID 11524703.
^ ^a ^b "Entrez Gene: PREPL prolyl endopeptidase-like".
^ "UniProt, Q4J6C6" (jezik: engleski). Pristupljeno 14. 11. 2021.

Dopunska literatura

Martens K, Derua R, Meulemans S, et al. (2006). "PREPL: a putative novel oligopeptidase propelled into the limelight". Biol. Chem. 387 (7): 879–883. doi:10.1515/BC.2006.111. PMID 16913837. S2CID 7983864.
Robertson NG, Khetarpal U, Gutiérrez-Espeleta GA, et al. (1995). "Isolation of novel and known genes from a human fetal cochlear cDNA library using subtractive hybridization and differential screening". Genomics. 23 (1): 42–50. doi:10.1006/geno.1994.1457. PMID 7829101.
Ishikawa K, Nagase T, Nakajima D, et al. (1998). "Prediction of the coding sequences of unidentified human genes. VIII. 78 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 4 (5): 307–313. doi:10.1093/dnares/4.5.307. PMID 9455477.
Kim DK, Kanai Y, Choi HW, et al. (2002). "Characterization of the system L amino acid transporter in T24 human bladder carcinoma cells". Biochim. Biophys. Acta. 1565 (1): 112–122. doi:10.1016/S0005-2736(02)00516-3. PMID 12225859.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–16903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Parvari R, Gonen Y, Alshafee I, et al. (2005). "The 2p21 deletion syndrome: characterization of the transcription content". Genomics. 86 (2): 195–211. doi:10.1016/j.ygeno.2005.04.001. PMID 15913950.
Szeltner Z, Alshafee I, Juhász T, et al. (2005). "The PREPL A protein, a new member of the prolyl oligopeptidase family, lacking catalytic activity". Cell. Mol. Life Sci. 62 (19–20): 2376–2381. doi:10.1007/s00018-005-5262-5. PMID 16143824. S2CID 11081394.
Jaeken J, Martens K, Francois I, et al. (2006). "Deletion of PREPL, a gene encoding a putative serine oligopeptidase, in patients with hypotonia-cystinuria syndrome". Am. J. Hum. Genet. 78 (1): 38–51. doi:10.1086/498852. PMC 1380222. PMID 16385448.

Vanjski linkovi

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000138078 - Ensembl, maj 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000024127 - Ensembl, maj 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid11524703-5] Parvari R, Brodyansky I, Elpeleg O, Moses S, Landau D, Hershkovitz E (Sep 2001). "A recessive contiguous gene deletion of chromosome 2p16 associated with cystinuria and a mitochondrial disease". Am J Hum Genet. 69 (4): 869–875. doi:10.1086/323624. PMC 1226072. PMID 11524703.

[entrez-6] "Entrez Gene: PREPL prolyl endopeptidase-like".

[UniProt-7] "UniProt, Q4J6C6" (jezik: engleski). Pristupljeno 14. 11. 2021.

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