POP7

Proteinska podjedinica p20 ribonukleaze P je enzim koji je kod ljudi kodiran genom POP7.

POP7
Identifikatori
Aliasi	POP7
Vanjski ID-jevi	OMIM: 606113 MGI: 1921347 HomoloGene: 4262 GeneCards: POP7
Lokacija gena (čovjek) Hrom. Hromosom 7 (čovjek) Bend 7q22.1 Početak 100,706,121 bp Kraj 100,707,486 bp
Lokacija gena (miš) Hrom. Hromosom 5 (miš) Bend 5|5 G2 Početak 137,499,700 bp Kraj 137,500,780 bp
Obrazac RNK ekspresije Više referentnih podataka o ekspresiji
Ontologija gena Molekularna funkcija • nucleic acid binding • GO:0001948, GO:0016582 vezivanje za proteine • hydrolase activity • vezivanje sa RNK • ribonuclease P activity Ćelijska komponenta • citoplazma • Jedarce • jedro • nucleolar ribonuclease P complex • nukleoplazma • ribonuclease MRP complex • multimeric ribonuclease P complex Biološki proces • tRNA processing • RNA phosphodiester bond hydrolysis, endonucleolytic • tRNA 5'-leader removal • RNA phosphodiester bond hydrolysis Izvori:Amigo / QuickGO
Ortolozi
Vrste	Čovjek	Miš
Entrez	10248	74097
Ensembl	ENSG00000172336	ENSMUSG00000029715
UniProt	O75817	Q9DCH2
RefSeq (mRNK)	NM_005837	NM_028753
RefSeq (bjelančevina)	NP_005828	NP_083029
Lokacija (UCSC)	Chr 7: 100.71 – 100.71 Mb	Chr 5: 137.5 – 137.5 Mb
PubMed pretraga
Wikipodaci
Pogledaj/uredi – čovjek Pogledaj/uredi – miš

Aminokiselinska sekvenca

Dužina polipeptidnog lanca je 140 aminokiselina, а molekulska težina Da. 15 651

• C: Cistein
• D: Asparaginska kiselina
• E: Glutaminska kiselina
• F: Fenilalanin
• G: Glicin
• H: Histidin
• I: Izoleucin
• K: Lizin
• L: Leucin
• M: Metionin
• N: Asparagin
• P: Prolin
• Q: Glutamin
• R: Arginin
• S: Serin
• T: Treonin
• V: Valin
• W: Triptofan
• Y: Tirozin

10		20		30		40		50
MAENREPRGA		VEAELDPVEY		TLRKRLPSRL		PRRPNDIYVN		MKTDFKAQLA
RCQKLLDGGA		RGQNACSEIY		IHGLGLAINR		AINIALQLQA		GSFGSLQVAA
NTSTVELVDE		LEPETDTREP		LTRIRNNSAI		HIRVFRVTPK

Dopuska literatura

• Stolc V, Katz A, Altman S (1998). "Rpp2, an essential protein subunit of nuclear RNase P, is required for processing of precursor tRNAs and 35S precursor rRNA in Saccharomyces cerevisiae". Proc. Natl. Acad. Sci. U.S.A. 95 (12): 6716–21. doi:10.1073/pnas.95.12.6716. PMC 22609. PMID 9618478.
• Jiang T, Altman S (2001). "Protein-protein interactions with subunits of human nuclear RNase P." Proc. Natl. Acad. Sci. U.S.A. 98 (3): 920–5. doi:10.1073/pnas.021561498. PMC 14685. PMID 11158571.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Scherer SW, Cheung J, MacDonald JR, et al. (2003). "Human chromosome 7: DNA sequence and biology". Science. 300 (5620): 767–72. doi:10.1126/science.1083423. PMC 2882961. PMID 12690205.
• Hua Y, Zhou J (2004). "Rpp20 interacts with SMN and is re-distributed into SMN granules in response to stress". Biochem. Biophys. Res. Commun. 314 (1): 268–76. doi:10.1016/j.bbrc.2003.12.084. PMID 14715275.
• Welting TJ, van Venrooij WJ, Pruijn GJ (2004). "Mutual interactions between subunits of the human RNase MRP ribonucleoprotein complex". Nucleic Acids Res. 32 (7): 2138–46. doi:10.1093/nar/gkh539. PMC 407822. PMID 15096576.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Andersen JS, Lam YW, Leung AK, et al. (2005). "Nucleolar proteome dynamics". Nature. 433 (7021): 77–83. doi:10.1038/nature03207. PMID 15635413. S2CID 4344740.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.

Vanjski linkovi

• POP7 lokacija ljudskog genoma UCSC Genome Browser.

POP7 detalji ljudskog genoma u UCSC Genome Browser.