Fosfatidilinozitol-5-fosfat 4-kinaza, tip II, gama je enzim koji je kod ljudi kodiran genom PIP4K2C.[5] Jedan je od fosfatidilinozitol 4-fosfat 5-kinaza.

PIP4K2C
Dostupne strukture
PDBPretraga ortologa: PDBe RCSB
Spisak PDB ID kodova

2GK9

Identifikatori
AliasiPIP4K2C
Vanjski ID-jeviOMIM: 617104 MGI: 2152214 HomoloGene: 23484 GeneCards: PIP4K2C
Lokacija gena (čovjek)
Hromosom 12 (čovjek)
Hrom.Hromosom 12 (čovjek)[1]
Hromosom 12 (čovjek)
Genomska lokacija za PIP4K2C
Genomska lokacija za PIP4K2C
Bend12q13.3Početak57,591,174 bp[1]
Kraj57,603,418 bp[1]
Lokacija gena (miš)
Hromosom 10 (miš)
Hrom.Hromosom 10 (miš)[2]
Hromosom 10 (miš)
Genomska lokacija za PIP4K2C
Genomska lokacija za PIP4K2C
Bend10|10 D3Početak127,032,936 bp[2]
Kraj127,047,454 bp[2]
Ontologija gena
Molekularna funkcija aktivnost sa transferazom
nucleotide binding
kinase activity
phosphatidylinositol phosphate kinase activity
vezivanje identičnih proteina
ATP binding
1-phosphatidylinositol-5-phosphate 4-kinase activity
Ćelijska komponenta citoplazma
citosol
membrana
Autofagosom
Egzosom
Biološki proces phosphatidylinositol metabolic process
positive regulation of autophagosome assembly
Fosforilacija
phosphatidylinositol phosphate biosynthetic process
regulation of autophagy
phosphatidylinositol biosynthetic process
regulation of phosphatidylinositol 3-kinase signaling
Izvori:Amigo / QuickGO
Ortolozi
VrsteČovjekMiš
Entrez
Ensembl
UniProt
RefSeq (mRNK)

NM_001146258
NM_001146259
NM_001146260
NM_024779

NM_054097
NM_001359280

RefSeq (bjelančevina)

NP_001139730
NP_001139731
NP_001139732
NP_079055

NP_473438
NP_001346209

Lokacija (UCSC)Chr 12: 57.59 – 57.6 MbChr 10: 127.03 – 127.05 Mb
PubMed pretraga[3][4]
Wikipodaci
Pogledaj/uredi – čovjekPogledaj/uredi – miš

Aminokiselinska sekvenca

uredi

Dužina polipeptidnog lanca je 421 aminokiselina, a molekulska težina 47.300 Da.[6]

Simboli
1020304050
MASSSVPPATVSAATAGPGPGFGFASKTKKKHFVQQKVKVFRAADPLVGV
FLWGVAHSINELSQVPPPVMLLPDDFKASSKIKVNNHLFHRENLPSHFKF
KEYCPQVFRNLRDRFGIDDQDYLVSLTRNPPSESEGSDGRFLISYDRTLV
IKEVSSEDIADMHSNLSNYHQYIVKCHGNTLLPQFLGMYRVSVDNEDSYM
LVMRNMFSHRLPVHRKYDLKGSLVSREASDKEKVKELPTLKDMDFLNKNQ
KVYIGEEEKKIFLEKLKRDVEFLVQLKIMDYSLLLGIHDIIRGSEPEEEA
PVREDESEVDGDCSLTGPPALVGSYGTSPEGIGGYIHSHRPLGPGEFESF
IDVYAIRSAEGAPQKEVYFMGLIDILTQYDAKKKAAHAAKTVKHGAGAEI
STVHPEQYAKRFLDFITNIFA

Reference

uredi
  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000166908 - Ensembl, maj 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000025417 - Ensembl, maj 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: Phosphatidylinositol-5-phosphate 4-kinase, type II, gamma".
  6. ^ "UniProt, Q8TBX8". Pristupljeno 12. 8. 2021.

Vanjski linkovi

uredi
  • PDBe-KB provides an overview of all the structure information available in the PDB for Human Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma (PIP4K2C)