14-kilodaltonska fosfohistidin-fosfataza je enzim koji je kod ljudi kodiran genom PHPT1.[5][6][7]

PHPT1
Dostupne strukture
PDBPretraga ortologa: PDBe RCSB
Spisak PDB ID kodova

2AI6, 2HW4, 2NMM, 2OZW, 2OZX

Identifikatori
AliasiPHPT1
Vanjski ID-jeviOMIM: 610167 MGI: 1922704 HomoloGene: 8573 GeneCards: PHPT1
Lokacija gena (čovjek)
Hromosom 9 (čovjek)
Hrom.Hromosom 9 (čovjek)[1]
Hromosom 9 (čovjek)
Genomska lokacija za PHPT1
Genomska lokacija za PHPT1
Bend9q34.3Početak136,848,724 bp[1]
Kraj136,851,027 bp[1]
Lokacija gena (miš)
Hromosom 2 (miš)
Hrom.Hromosom 2 (miš)[2]
Hromosom 2 (miš)
Genomska lokacija za PHPT1
Genomska lokacija za PHPT1
Bend2|2 A3Početak25,463,442 bp[2]
Kraj25,465,236 bp[2]
Ontologija gena
Molekularna funkcija calcium channel inhibitor activity
phosphoprotein phosphatase activity
hydrolase activity
transmembrane transporter binding
GO:0001948, GO:0016582 vezivanje za proteine
protein histidine phosphatase activity
Ćelijska komponenta citoplazma
citosol
Egzosom
Biološki proces negative regulation of lyase activity
positive regulation of insulin secretion involved in cellular response to glucose stimulus
GO:0016576 protein dephosphorylation
regulation of actin cytoskeleton reorganization
peptidyl-histidine dephosphorylation
negative regulation of ATP citrate synthase activity
positive regulation of cell motility
negative regulation of T cell receptor signaling pathway
Izvori:Amigo / QuickGO
Ortolozi
VrsteČovjekMiš
Entrez
Ensembl
UniProt
RefSeq (mRNK)

NM_001135860
NM_001135861
NM_001287342
NM_001287343
NM_014172

NM_029293

RefSeq (bjelančevina)

NP_001129333
NP_001274271
NP_001274272
NP_054891

NP_083569

Lokacija (UCSC)Chr 9: 136.85 – 136.85 MbChr 2: 25.46 – 25.47 Mb
PubMed pretraga[3][4]
Wikipodaci
Pogledaj/uredi – čovjekPogledaj/uredi – miš

Aminokiselinska sekvenca

uredi

Dužina polipeptidnog lanca je 125 aminokiselina, а molekulska težina 13.833 Da.[8]

1020304050
MAVADLALIPDVDIDSDGVFKYVLIRVHSAPRSGAPAAESKEIVRGYKWA
EYHADIYDKVSGDMQKQGCDCECLGGGRISHQSQDKKIHVYGYSMAYGPA
QHAISTEKIKAKYPDYEVTWANDGY

Reference

uredi
  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000054148 - Ensembl, maj 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000036504 - Ensembl, maj 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Zhang QH, Ye M, Wu XY, Ren SX, Zhao M, Zhao CJ, Fu G, Shen Y, Fan HY, Lu G, Zhong M, Xu XR, Han ZG, Zhang JW, Tao J, Huang QH, Zhou J, Hu GX, Gu J, Chen SJ, Chen Z (Nov 2000). "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells". Genome Res. 10 (10): 1546–60. doi:10.1101/gr.140200. PMC 310934. PMID 11042152.
  6. ^ Andersson B, Wentland MA, Ricafrente JY, Liu W, Gibbs RA (Jun 1996). "A "double adaptor" method for improved shotgun library construction". Anal Biochem. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474.
  7. ^ "Entrez Gene: PHPT1 phosphohistidine phosphatase 1".
  8. ^ "UniProt, Q9NRX4". Pristupljeno 2021-09-10.

Dopunska literatura

uredi

Vanjski linkovi

uredi