PHF2
Protein PHD-prsta 2 je protein koji je kod ljudi kodiran genom PHF2.[5]
Aminokiselinska sekvenca
urediDužina polipeptidnog lanca je 1.096 aminokiselina, а molekulska težina Da. 120 775[6]
10 | 20 | 30 | 40 | 50 | ||||
---|---|---|---|---|---|---|---|---|
MATVPVYCVC | RLPYDVTRFM | IECDACKDWF | HGSCVGVEEE | EAPDIDIYHC | ||||
PNCEKTHGKS | TLKKKRTWHK | HGPGQAPDVK | PVQNGSQLFI | KELRSRTFPS | ||||
AEDVVARVPG | SQLTLGYMEE | HGFTEPILVP | KKDGLGLAVP | APTFYVSDVE | ||||
NYVGPERSVD | VTDVTKQKDC | KMKLKEFVDY | YYSTNRKRVL | NVTNLEFSDT | ||||
RMSSFVEPPD | IVKKLSWVEN | YWPDDALLAK | PKVTKYCLIC | VKDSYTDFHI | ||||
DSGGASAWYH | VLKGEKTFYL | IRPASANISL | YERWRSASNH | SEMFFADQVD | ||||
KCYKCIVKQG | QTLFIPSGWI | YATLTPVDCL | AFAGHFLHSL | SVEMQMRAYE | ||||
VERRLKLGSL | TQFPNFETAC | WYMGKHLLEA | FKGSHKSGKQ | LPPHLVQGAK | ||||
ILNGAFRSWT | KKQALAEHED | ELPEHFKPSQ | LIKDLAKEIR | LSENASKAVR | ||||
PEVNTVASSD | EVCDGDREKE | EPPSPIEATP | PQSLLEKVSK | KKTPKTVKMP | ||||
KPSKIPKPPK | PPKPPRPPKT | LKLKDGGKKK | GKKSRESASP | TIPNLDLLEA | ||||
HTKEALTKME | PPKKGKATKS | VLSVPNKDVV | HMQNDVERLE | IREQTKSKSE | ||||
AKWKYKNSKP | DSLLKMEEEQ | KLEKSPLAGN | KDNKFSFSFS | NKKLLGSKAL | ||||
RPPTSPGVFG | ALQNFKEDKP | KPVRDEYEYV | SDDGELKIDE | FPIRRKKNAP | ||||
KRDLSFLLDK | KAVLPTPVTK | PKLDSAAYKS | DDSSDEGSLH | IDTDTKPGRN | ||||
ARVKKESGSS | AAGILDLLQA | SEEVGALEYN | PSSQPPASPS | TQEAIQGMLS | ||||
MANLQASDSC | LQTTWGAGQA | KGSSLAAHGA | RKNGGGSGKS | AGKRLLKRAA | ||||
KNSVDLDDYE | EEQDHLDACF | KDSDYVYPSL | ESDEDNPIFK | SRSKKRKGSD | ||||
DAPYSPTARV | GPSVPRQDRP | VREGTRVASI | ETGLAAAAAK | LSQQEEQKSK | ||||
KKKSAKRKLT | PNTTSPSTST | SISAGTTSTS | TTPASTTPAS | TTPASTSTAS | ||||
SQASQEGSSP | EPPPESHSSS | LADHEYTAAG | TFTGAQAGRT | SQPMAPGVFL | ||||
TQRRPSASSP | NNNTAAKGKR | TKKGMATAKQ | RLGKILKIHR | NGKLLL |
Funkcija
urediOvaj gen kodira protein koji sadrži prst poput cinkovog prsta PHD (biljni homeodomen), za razliku od drugih klasa motiva cinkovog prsta, te hidrofobni i visoko konzervirani domen . PHD prst prikazuje tipski aranžman Cys4–His–Cys3. Smatra se da geni PHD-prstiju pripadaju raznolikoj skupini transkripcijskih regulatora koji mogu uticati na ekspresiju gena eukariota, utičući na strukturu hromatina.
Reference
uredi- ^ a b c GRCh38: Ensembl release 89: ENSG00000197724 - Ensembl, maj 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000038025 - Ensembl, maj 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Entrez Gene: PHD finger protein 2". Pristupljeno 9. 4. 2016.
- ^ "UniProt, O75151". Pristupljeno 10. 9. 2021.
Dopunska literatura
uredi- Sinha S, Singh RK, Alam N, Roy A, Roychoudhury S, Panda CK (2008). "Alterations in candidate genes PHF2, FANCC, PTCH1 and XPA at chromosomal 9q22.3 region: pathological significance in early- and late-onset breast carcinoma". Mol. Cancer. 7: 84. doi:10.1186/1476-4598-7-84. PMC 2633285. PMID 18990233.