PGA3

Pepsinogen 3 grupe I (pepsinogen A) je protein koji je kod ljudi kodiran genom PGA3.

PGA3
Identifikatori
Aliasi	PGA3
Vanjski ID-jevi	HomoloGene: 68135 GeneCards: PGA3
Lokacija gena (čovjek) Hrom. Hromosom 11 (čovjek) Bend 11q12.2 Početak 61,203,307 bp Kraj 61,213,098 bp
Ontologija gena Molekularna funkcija • hydrolase activity • GO:0070122 peptidase activity • aspartic-type endopeptidase activity Ćelijska komponenta • extracellular region • Egzosom • multivesicular body lumen Biološki proces • varenje • Proteoliza • Autofagija • GO:0044257 protein catabolic process Izvori:Amigo / QuickGO
Ortolozi
Vrste	Čovjek	Miš
Entrez	643834	n/a
Ensembl	ENSG00000229859	n/a
UniProt	P0DJD8	n/a
RefSeq (mRNK)	NM_001079807	n/a
RefSeq (bjelančevina)	NP_001073275	n/a
Lokacija (UCSC)	Chr 11: 61.2 – 61.21 Mb	n/a
PubMed pretraga		n/a
Wikipodaci
Pogledaj/uredi – čovjek

Aminokiselinska sekvenca

Dužina polipeptidnog lanca je 388 aminokiselina, a molekulska težina 41.976 Da.

• C: Cistein
• D: Asparaginska kiselina
• E: Glutaminska kiselina
• F: Fenilalanin
• G: Glicin
• H: Histidin
• I: Izoleucin
• K: Lizin
• L: Leucin
• M: Metionin
• N: Asparagin
• P: Prolin
• Q: Glutamin
• R: Arginin
• S: Serin
• T: Treonin
• V: Valin
• W: Triptofan
• Y: Tirozin

10		20		30		40		50
MKWLLLLGLV		ALSECIMYKV		PLIRKKSLRR		TLSERGLLKD		FLKKHNLNPA
RKYFPQWKAP		TLVDEQPLEN		YLDMEYFGTI		GIGTPAQDFT		VVFDTGSSNL
WVPSVYCSSL		ACTNHNRFNP		EDSSTYQSTS		ETVSITYGTG		SMTGILGYDT
VQVGGISDTN		QIFGLSETEP		GSFLYYAPFD		GILGLAYPSI		SSSGATPVFD
NIWNQGLVSQ		DLFSVYLSAD		DQSGSVVIFG		GIDSSYYTGS		LNWVPVTVEG
YWQITVDSIT		MNGEAIACAE		GCQAIVDTGT		SLLTGPTSPI		ANIQSDIGAS
ENSDGDMVVS		CSAISSLPDI		VFTINGVQYP		VPPSAYILQS		EGSCISGFQG
MNLPTESGEL		WILGDVFIRQ		YFTVFDRANN		QVGLAPVA

Funkcija

Ovaj gen kodira proteinski prekursor probavnog enzima pepsina, člana A1 porodice peptidaznih endopeptidaza. Kodirani prekursor izlučuju glavne ćelije želuca i podvrgavaju se autokatalitskom cijepanju u kiselim uvjetima, kako bi se formirao aktivni enzim, koji funkcionira u probavi proteina u prehrani. Ovaj gen nalazi se u grupi povezanih gena na hromosomu 11, od kojih svaki kodira jedan od više pepsinogena. Nivo pepsinogena u serumu može poslužiti kao biomarker za atrofijski gastritis i rak želuca.

Dopunska literatura

• Shiotani A, Iishi H, Uedo N, Kumamoto M, Nakae Y, Ishiguro S, Tatsuta M, Graham DY (2005). "Histologic and serum risk markers for noncardia early gastric cancer". Int. J. Cancer. 115 (3): 463–9. doi:10.1002/ijc.20852. PMID 15688378. S2CID 41463184.
• Pimanov SI, Makarenko EV, Voropaeva AV, Matveenko ME, Voropaev EV (2008). "Helicobacter pylori eradication improves gastric histology and decreases serum gastrin, pepsinogen I and pepsinogen II levels in patients with duodenal ulcer". J. Gastroenterol. Hepatol. 23 (11): 1666–71. doi:10.1111/j.1440-1746.2007.04983.x. PMID 17559360. S2CID 30895361.
• Kamangar F, Diaw L, Wei WQ, Abnet CC, Wang GQ, Roth MJ, Liu B, Lu N, Giffen C, Qiao YL, Dawsey SM (2009). "Serum pepsinogens and risk of esophageal squamous dysplasia". Int. J. Cancer. 124 (2): 456–60. doi:10.1002/ijc.23918. PMC 2605159. PMID 18844222.
• Abe Y, Iijima K, Koike T, Asanuma K, Imatani A, Ohara S, Shimosegawa T (2009). "Barrett's esophagus is characterized by the absence of Helicobacter pylori infection and high levels of serum pepsinogen I concentration in Japan". J. Gastroenterol. Hepatol. 24 (1): 129–34. doi:10.1111/j.1440-1746.2008.05691.x. PMID 19196398. S2CID 2816506.
• Peitz U, Wex T, Vieth M, Stolte M, Willich S, Labenz J, Jaspersen D, Lind T, Malfertheiner P (2011). "Correlation of serum pepsinogens and gastrin-17 with atrophic gastritis in gastroesophageal reflux patients: a matched-pairs study". J. Gastroenterol. Hepatol. 26 (1): 82–9. doi:10.1111/j.1440-1746.2010.06413.x. PMID 21175799. S2CID 23091933.
• Shafaghi A, Mansour-Ghanaei F, Joukar F, Sharafkhah M, Mesbah A, Askari K, Geranmayeh S, Mehrvarz A, Souti F, Sokhanvar H, Fakhrieh S, Aminian K, Yousefi-Mashhour M, Khosh-Sorur M, Rasoulian J (2013). "Serum gastrin and the pepsinogen I/II ratio as markers for diagnosis of premalignant gastric lesions". Asian Pac. J. Cancer Prev. 14 (6): 3931–6. doi:10.7314/apjcp.2013.14.6.3931. PMID 23886209.
• Tu H, Sun L, Dong X, Gong Y, Xu Q, Jing J, Long Q, Flanders WD, Bostick RM, Yuan Y (2015). "Temporal changes in serum biomarkers and risk for progression of gastric precancerous lesions: a longitudinal study". Int. J. Cancer. 136 (2): 425–34. doi:10.1002/ijc.29005. PMC 4354768. PMID 24895149.