PELI1

Prenilcistein-oksidaza 1 jest enzim koji je kod ljudi kodiran genom PCYOX1 sa hromosoma 2.

PELI1
Identifikatori
Aliasi	PELI1
Vanjski ID-jevi	OMIM: 614797 MGI: 1914495 HomoloGene: 23243 GeneCards: PELI1
Lokacija gena (čovjek) Hrom. Hromosom 2 (čovjek) Bend 2p14 Početak 64,092,652 bp Kraj 64,144,420 bp
Lokacija gena (miš) Hrom. Hromosom 11 (miš) Bend 11 A3.1|11 13.81 cM Početak 21,041,291 bp Kraj 21,100,323 bp
Obrazac RNK ekspresije Više referentnih podataka o ekspresiji
Ontologija gena Molekularna funkcija • GO:0050372 aktivnost sa transferazom ubikvitina • GO:0001948, GO:0016582 vezivanje za proteine • ubiquitin-ubiquitin ligase activity • protein serine/threonine kinase activity • aktivnost sa transferazom • GO:1904264, GO:1904822, GO:0090622, GO:0090302 ubiquitin protein ligase activity Ćelijska komponenta • citosol • jedro Biološki proces • response to dsRNA • positive regulation of toll-like receptor 3 signaling pathway • GO:0032737 positive regulation of cytokine production • protein polyubiquitination • negative regulation of T cell proliferation • response to lipopolysaccharide • positive regulation of B cell proliferation • protein ubiquitination • positive regulation of toll-like receptor 4 signaling pathway • positive regulation of I-kappaB kinase/NF-kappaB signaling • positive regulation of B cell activation • negative regulation of NF-kappaB transcription factor activity • positive regulation of protein ubiquitination • negative regulation of T cell activation • protein phosphorylation • GO:0046730, GO:0046737, GO:0046738, GO:0046736 Imuni odgovor • Toll signaling pathway • protein K48-linked ubiquitination • interleukin-1-mediated signaling pathway • proteasome-mediated ubiquitin-dependent protein catabolic process • negative regulation of necroptotic process • protein K63-linked ubiquitination • regulation of Toll signaling pathway Izvori:Amigo / QuickGO
Ortolozi
Vrste	Čovjek	Miš
Entrez	57162	67245
Ensembl	ENSG00000197329	ENSMUSG00000020134
UniProt	Q96FA3	Q8C669
RefSeq (mRNK)	NM_020651	NM_023324
RefSeq (bjelančevina)	NP_065702	NP_075813
Lokacija (UCSC)	Chr 2: 64.09 – 64.14 Mb	Chr 11: 21.04 – 21.1 Mb
PubMed pretraga
Wikipodaci
Pogledaj/uredi – čovjek Pogledaj/uredi – miš

Amiokiselininska sekvenca

Dužina polipeptidnog lanca je 505 aminokiselina, a molekulska težina 56.640 Da.

• C: Cistein
• D: Asparaginska kiselina
• E: Glutaminska kiselina
• F: Fenilalanin
• G: Glicin
• H: Histidin
• I: Izoleucin
• K: Lizin
• L: Leucin
• M: Metionin
• N: Asparagin
• P: Prolin
• Q: Glutamin
• R: Arginin
• S: Serin
• T: Treonin
• V: Valin
• W: Triptofan
• Y: Tirozin

10		20		30		40		50
MGRVVAELVS		SLLGLWLLLC		SCGCPEGAEL		RAPPDKIAII		GAGIGGTSAA
YYLRQKFGKD		VKIDLFEREE		VGGRLATMMV		QGQEYEAGGS		VIHPLNLHMK
RFVKDLGLSA		VQASGGLLGI		YNGETLVFEE		SNWFIINVIK		LVWRYGFQSL
RMHMWVEDVL		DKFMRIYRYQ		SHDYAFSSVE		KLLHALGGDD		FLGMLNRTLL
ETLQKAGFSE		KFLNEMIAPV		MRVNYGQSTD		INAFVGAVSL		SCSDSGLWAV
EGGNKLVCSG		LLQASKSNLI		SGSVMYIEEK		TKTKYTGNPT		KMYEVVYQIG
TETRSDFYDI		VLVATPLNRK		MSNITFLNFD		PPIEEFHQYY		QHIVTTLVKG
ELNTSIFSSR		PIDKFGLNTV		LTTDNSDLFI		NSIGIVPSVR		EKEDPEPSTD
GTYVWKIFSQ		ETLTKAQILK		LFLSYDYAVK		KPWLAYPHYK		PPEKCPSIIL
HDRLYYLNGI		ECAASAMEMS		AIAAHNAALL		AYHRWNGHTD		MIDQDGLYEK
LKTEL

Također pogledajte

• Prenilcistein-oksidaza

Dopunska literatura

• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Zhang L, Tschantz WR, Casey PJ (1997). "Isolation and characterization of a prenylcysteine lyase from bovine brain". J. Biol. Chem. 272 (37): 23354–9. doi:10.1074/jbc.272.37.23354. PMID 9287348.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Nagase T, Ishikawa K, Suyama M, et al. (1999). "Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 5 (6): 355–64. doi:10.1093/dnares/5.6.355. PMID 10048485.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Clark HF, Gurney AL, Abaya E, et al. (2003). "The Secreted Protein Discovery Initiative (SPDI), a Large-Scale Effort to Identify Novel Human Secreted and Transmembrane Proteins: A Bioinformatics Assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Liu T, Qian WJ, Gritsenko MA, et al. (2006). "Human Plasma N-Glycoproteome Analysis by Immunoaffinity Subtraction, Hydrazide Chemistry, and Mass Spectrometry". J. Proteome Res. 4 (6): 2070–80. doi:10.1021/pr0502065. PMC 1850943. PMID 16335952.
• Wouters MM, Neefs JM, Kerchove d'Exaerde A, et al. (2006). "Downregulation of two novel genes in Sl/Sld and W(LacZ)/Wv mouse jejunum". Biochem. Biophys. Res. Commun. 346 (2): 491–500. doi:10.1016/j.bbrc.2006.05.132. PMID 16765319.