PDCD7

PDCD7
Identifikatori
Aliasi	PDCD7
Vanjski ID-jevi	OMIM: 608138 MGI: 1859170 HomoloGene: 4170 GeneCards: PDCD7
Lokacija gena (čovjek)
Hrom.	Hromosom 15 (čovjek)
Kraj	65,133,808 bp
Lokacija gena (miš)
Hrom.	Hromosom 9 (miš)
Kraj	65,266,925 bp
Ortolozi
	10081
	50996
	ENSG00000090470
	ENSMUSG00000041837
	Q8N8D1
	Q9WTY1
	NM_005707
	NM_016688
	NP_005698
	n/a
	Wikipodaci
Pogledaj/uredi – čovjek	Pogledaj/uredi – miš

Protein 7 programirane ćelijske smrti je protein koji je kod ljudi kodiran genom PDCD7.^[5]^[6]

Ovaj gen kodira protein slične sekvence mišjeg proteina koji je izvorno identificiran u embrionskim matičnim ćelijaka. U mišjim T-ćelijskim linijama ovaj protein povezan je sa glukokortikoidima i apoptotskim putevima izazvanim staurinom i povezan sa keramid omposredovanom signalizacijom. Ova zapažanja sugeriraju da je ovaj genski proizvod uključen u specifične apoptozne procese u T-ćelijama.^[6]

Aminokiselinska sekvenca

Dužina polipeptidnog lanca je 485 aminokiselina, a molekulska težina 54.700 Da.^[7].

10	20	30	40	50
MALPPFFGQG	RPGPPPPQPP	PPAPFGCPPP	PLPSPAFPPP	LPQRPGPFPG
ASAPFLQPPL	ALQPRASAEA	SRGGGGAGAF	YPVPPPPLPP	PPPQCRPFPG
TDAGERPRPP	PPGPGPPWSP	RWPEAPPPPA	DVLGDAALQR	LRDRQWLEAV
FGTPRRAGCP	VPQRTHAGPS	LGEVRARLLR	ALRLVRRLRG	LSQALREAEA
DGAAWVLLYS	QTAPLRAELA	ERLQPLTQAA	YVGEARRRLE	RVRRRRLRLR
ERAREREAER	EAEAARAVER	EQEIDRWRVK	CVQEVEEKKR	EQELKAAADG
VLSEVRKKQA	DTKRMVDILR	ALEKLRKLRK	EAAARKGVCP	PASADETFTH
HLQRLRKLIK	KRSELYEAEE	RALRVMLEGE	QEEERKRELE	KKQRKEKEKI
LLQKREIESK	LFGDPDEFPL	AHLLEPFRQY	YLQAEHSLPA	LIQIRHDWDQ
YLVPSDHPKG	NFVPQGWVLP	PLPSNDIWAT	AVKLH

Simboli

C: Cistein
D: Asparaginska kiselina
E: Glutaminska kiselina
F: Fenilalanin
G: Glicin
H: Histidin
I: Izoleucin
K: Lizin
L: Leucin
M: Metionin
N: Asparagin
P: Prolin
Q: Glutamin
R: Arginin
S: Serin
T: Treonin
V: Valin
W: Triptofan
Y: Tirozin

Reference

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000090470 - Ensembl, maj 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000041837 - Ensembl, maj 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Park EJ, Kim JH, Seong RH, Kim CG, Park SD, Hong SH (Apr 1999). "Characterization of a novel mouse cDNA, ES18, involved in apoptotic cell death of T-cells". Nucleic Acids Res. 27 (6): 1524–30. doi:10.1093/nar/27.6.1524. PMC 148348. PMID 10037816.
^ ^a ^b "Entrez Gene: PDCD7 programmed cell death 7".
^ "UniProt, Q8N8D1". Pristupljeno 16. 7. 2021.

Dopunska literatura

Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Colland F, Jacq X, Trouplin V, et al. (2004). "Functional Proteomics Mapping of a Human Signaling Pathway". Genome Res. 14 (7): 1324–32. doi:10.1101/gr.2334104. PMC 442148. PMID 15231748.
Will CL, Schneider C, Hossbach M, et al. (2004). "The human 18S U11/U12 snRNP contains a set of novel proteins not found in the U2-dependent spliceosome". RNA. 10 (6): 929–41. doi:10.1261/rna.7320604. PMC 1370585. PMID 15146077.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.

Vanjski linkovi

PDCD7 lokacija ljudskog genoma UCSC Genome Browser.

PDCD7 detalji ljudskog genoma u UCSC Genome Browser.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000090470 - Ensembl, maj 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000041837 - Ensembl, maj 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10037816-5] Park EJ, Kim JH, Seong RH, Kim CG, Park SD, Hong SH (Apr 1999). "Characterization of a novel mouse cDNA, ES18, involved in apoptotic cell death of T-cells". Nucleic Acids Res. 27 (6): 1524–30. doi:10.1093/nar/27.6.1524. PMC 148348. PMID 10037816.

[entrez-6] "Entrez Gene: PDCD7 programmed cell death 7".

[UniProt-7] "UniProt, Q8N8D1". Pristupljeno 16. 7. 2021.

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