OTUD1

OTUD1
Dostupne strukture
PDB	Pretraga ortologa: PDBe RCSB
Spisak PDB ID kodova
	4BOP
Identifikatori
Aliasi	OTUD1
Vanjski ID-jevi	OMIM: 612022 MGI: 1918448 HomoloGene: 45953 GeneCards: OTUD1
Lokacija gena (čovjek)
Hrom.	Hromosom 10 (čovjek)
Kraj	23,442,377 bp
Lokacija gena (miš)
Hrom.	Hromosom 2 (miš)
Kraj	19,665,394 bp
Ortolozi
	220213
	71198
	ENSG00000165312
	ENSMUSG00000043415
	Q5VV17
	Q9CUB6
	NM_001145373
	NM_027715
	NP_001138845
	NP_081991
	Wikipodaci
Pogledaj/uredi – čovjek	Pogledaj/uredi – miš

OTU deubikvitinaza 1je protein koji je kod ljudi kodiran genom OTUD1.^[5]

Aminokiselinska sekvenca

Dužina polipeptidnog lanca je481 aminokiselina, а molekulska težina 51.063 Da.^[6]

C: Cistein

D: Asparaginska kiselina

E: Glutaminska kiselina

F: Fenilalanin

G: Glicin

H: Histidin

I: Izoleucin

K: Lizin

L: Leucin

M: Metionin

N: Asparagin

P: Prolin

Q: Glutamin

R: Arginin

S: Serin

T: Treonin

V: Valin

W: Triptofan

Y: Tirozin

10	20	30	40	50
MQLYSSVCTH	YPAGAPGPTA	AAPAPPAAAT	PFKVSLQPPG	AAGAAPEPET
GECQPAAAAE	HREAAAVPAA	KMPAFSSCFE	VVSGAAAPAS	AAAGPPGASC
KPPLPPHYTS	TAQITVRALG	ADRLLLHGPD	PVPGAAGSAA	APRGRCLLLA
PAPAAPVPPR	RGSSAWLLEE	LLRPDCPEPA	GLDATREGPD	RNFRLSEHRQ
ALAAAKHRGP	AATPGSPDPG	PGPWGEEHLA	ERGPRGWERG	GDRCDAPGGD
AARRPDPEAE	APPAGSIEAA	PSSAAEPVIV	SRSDPRDEKL	ALYLAEVEKQ
DKYLRQRNKY	RFHIIPDGNC	LYRAVSKTVY	GDQSLHRELR	EQTVHYIADH
LDHFSPLIEG	DVGEFIIAAA	QDGAWAGYPE	LLAMGQMLNV	NIHLTTGGRL
ESPTVSTMIH	YLGPEDSLRP	SIWLSWLSNG	HYDAVFDHSY	PNPEYDNWCK
QTQVQRKRDE	ELAKSMAISL	SKMYIEQNAC	S

Funkcija

Deubikvitinirajući enzimi (DUB; vidi MIM 603478) su proteaze koje specifično cijepaju veze ubikvitina (MIM 191339), negirajući djelovanje ubikvitinskih ligaza. DUBA7 pripada potporodici DUB koju karakterizira domen tumora jajnika (OTU).

Reference

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000165312 - Ensembl, maj 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000043415 - Ensembl, maj 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: OTU deubiquitinase 1". Pristupljeno 13. 3. 2016.
^ "UniProt, Q5VV17". Pristupljeno 3. 9. 2021.

Vanjski linkovi

PDBe-KB provides an overview of all the structure information available in the PDB for Human OTU domain-containing protein 1

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000165312 - Ensembl, maj 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000043415 - Ensembl, maj 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: OTU deubiquitinase 1". Pristupljeno 13. 3. 2016.

[UniProt-6] "UniProt, Q5VV17". Pristupljeno 3. 9. 2021.

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