OLFM1

OLFM1
Dostupne strukture
PDB	Pretraga ortologa: PDBe RCSB
Spisak PDB ID kodova
	4XAT
Identifikatori
Aliasi	OLFM1
Vanjski ID-jevi	OMIM: 605366 MGI: 1860437 HomoloGene: 8612 GeneCards: OLFM1
Lokacija gena (čovjek)
Hrom.	Hromosom 9 (čovjek)
Kraj	135,121,180 bp
Lokacija gena (miš)
Hrom.	Hromosom 2 (miš)
Kraj	28,120,748 bp
Obrazac RNK ekspresije
	; ; ; ;
	Više referentnih podataka o ekspresiji
Ontologija gena
Molekularna funkcija	• GO:0001948, GO:0016582 vezivanje za proteine;
Ćelijska komponenta	• extracellular region; • međućelijske veze; • Akson; • soma; • perikaryon; • axonal growth cone; • sinapsa; • projekcija ćelije; • Endoplazmatski retikulum; • Vanćelijsko;
Biološki proces	• multicellular organism development; • atrioventricular valve formation; • neuronal signal transduction; • GO:1901313 positive regulation of gene expression; • regulation of axon extension; • positive regulation of epithelial to mesenchymal transition; • negative regulation of gene expression; • nervous system development; • cardiac epithelial to mesenchymal transition; • positive regulation of apoptotic process;
	Izvori:Amigo / QuickGO
Ortolozi
	10439
	56177
	ENSG00000130558
	ENSMUSG00000026833
	Q99784
	O88998
	NM_058199; NM_001282611; NM_001282612; NM_006334; NM_014279
	NM_001038612; NM_001038613; NM_001038614; NM_019498
	NP_001269540; NP_001269541; NP_006325; NP_055094
	NP_001033701; NP_001033702; NP_001033703; NP_062371
	Wikipodaci
Pogledaj/uredi – čovjek	Pogledaj/uredi – miš

Olfaktomedin 1, znan i kao noelin 1 ili pankortin, je protein koji je kod ljudi kodiran genom OLFM1.^[5]^[6] The name noelin stands for "neuronal olfactomedin-related endoplasmic reticulum-localized 1".^[7]

Aminokiselinska sekvenca

Dužina polipeptidnog lanca je 485 aminokiselina, а molekulska težina 55.343 Da.^[8]

C: Cistein

D: Asparaginska kiselina

E: Glutaminska kiselina

F: Fenilalanin

G: Glicin

H: Histidin

I: Izoleucin

K: Lizin

L: Leucin

M: Metionin

N: Asparagin

P: Prolin

Q: Glutamin

R: Arginin

S: Serin

T: Treonin

V: Valin

W: Triptofan

Y: Tirozin

10	20	30	40	50
MSVPLLKIGV	VLSTMAMITN	WMSQTLPSLV	GLNTTKLSAA	GGGTLDRSTG
VLPTNPEESW	QVYSSAQDSE	GRCICTVVAP	QQTMCSRDAR	TKQLRQLLEK
VQNMSQSIEV	LDRRTQRDLQ	YVEKMENQMK	GLESKFKQVE	ESHKQHLARQ
FKAIKAKMDE	LRPLIPVLEE	YKADAKLVLQ	FKEEVQNLTS	VLNELQEEIG
AYDYDELQSR	VSNLEERLRA	CMQKLACGKL	TGISDPVTVK	TSGSRFGSWM
TDPLAPEGDN	RVWYMDGYHN	NRFVREYKSM	VDFMNTDNFT	SHRLPHPWSG
TGQVVYNGSI	YFNKFQSHII	IRFDLKTETI	LKTRSLDYAG	YNNMYHYAWG
GHSDIDLMVD	ESGLWAVYAT	NQNAGNIVVS	RLDPVSLQTL	QTWNTSYPKR
SAGEAFIICG	TLYVTNGYSG	GTKVHYAYQT	NASTYEYIDI	PFQNKYSHIS
MLDYNPKDRA	LYAWNNGHQI	LYNVTLFHVI	RSDEL

Funkcija

Ovaj genski proizvod ima veliku sličnost sekvence sa proteinom pacovskih neuronskih olfaktomedina povezanih sa proteinom u endoplazamatskom retikulumu (ER). Iako tačna funkcija kodiranog proteina nije poznata, njegova obilna ekspresija u mozgu sugerira da može imati bitnu ulogu u živčanom tkivu. Za ovaj gen pronađeno je nekoliko alternativno prerađenih transkripata koji kodiraju različite izoforme.^[6]

Kancer

Otkriveno je da gen OLFM1 progresivno aktivan u papiloma virus-pozitivanim neoplazmatskim keratinocitima izvedenim iz cerviksa materice preneoplazijske lezije na različitim nivoima malignosti.^[9] Zato je ovaj gen vjerovatno povezan s tumorigenezom i može biti potencijalni prognostički marker za napredovanje raka cerviksa maternice preneoplazijske lezije.^[9]

Reference

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000130558 - Ensembl, maj 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000026833 - Ensembl, maj 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Yokoyama M, Nishi Y, Yoshii J, Okubo K, Matsubara K (maj 1997). "Identification and cloning of neuroblastoma-specific and nerve tissue-specific genes through compiled expression profiles". DNA Res. 3 (5): 311–20. doi:10.1093/dnares/3.5.311. PMID 9039501.
^ ^a ^b "Entrez Gene: OLFM1 olfactomedin 1".
^ Anholt, Robert R. H. (2014). "Olfactomedin proteins: central players in development and disease". Frontiers in Cell and Developmental Biology. 2: 6. doi:10.3389/fcell.2014.00006. PMC 4206993. PMID 25364714.
^ "UniProt, Q99784". Pristupljeno 10. 9. 2021.
^ ^a ^b Rotondo JC, Bosi S, Bassi C, Ferracin M, Lanza G, Gafà R, Magri E, Selvatici R, Torresani S, Marci R, Garutti P, Negrini M, Tognon M, Martini F (april 2015). "Gene expression changes in progression of cervical neoplasia revealed by microarray analysis of cervical neoplastic keratinocytes". J Cell Physiol. 230 (4): 802–812. doi:10.1002/jcp.24808. PMID 25205602. S2CID 24986454.

Dopunska literatura

Andersson B, Wentland MA, Ricafrente JY, et al. (1996). "A "double adaptor" method for improved shotgun library construction". Anal. Biochem. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474.
Yu W, Andersson B, Worley KC, et al. (1997). "Large-Scale Concatenation cDNA Sequencing". Genome Res. 7 (4): 353–8. doi:10.1101/gr.7.4.353. PMC 139146. PMID 9110174.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Liu T, Qian WJ, Gritsenko MA, et al. (2006). "Human Plasma N-Glycoproteome Analysis by Immunoaffinity Subtraction, Hydrazide Chemistry, and Mass Spectrometry". J. Proteome Res. 4 (6): 2070–80. doi:10.1021/pr0502065. PMC 1850943. PMID 16335952.
Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
Camargo LM, Collura V, Rain JC, et al. (2007). "Disrupted in Schizophrenia 1 Interactome: evidence for the close connectivity of risk genes and a potential synaptic basis for schizophrenia". Mol. Psychiatry. 12 (1): 74–86. doi:10.1038/sj.mp.4001880. PMID 17043677.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000130558 - Ensembl, maj 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000026833 - Ensembl, maj 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9039501-5] Yokoyama M, Nishi Y, Yoshii J, Okubo K, Matsubara K (maj 1997). "Identification and cloning of neuroblastoma-specific and nerve tissue-specific genes through compiled expression profiles". DNA Res. 3 (5): 311–20. doi:10.1093/dnares/3.5.311. PMID 9039501.

[entrez-6] "Entrez Gene: OLFM1 olfactomedin 1".

[7] Anholt, Robert R. H. (2014). "Olfactomedin proteins: central players in development and disease". Frontiers in Cell and Developmental Biology. 2: 6. doi:10.3389/fcell.2014.00006. PMC 4206993. PMID 25364714.

[UniProt-8] "UniProt, Q99784". Pristupljeno 10. 9. 2021.

[Rotondo_2015-9] Rotondo JC, Bosi S, Bassi C, Ferracin M, Lanza G, Gafà R, Magri E, Selvatici R, Torresani S, Marci R, Garutti P, Negrini M, Tognon M, Martini F (april 2015). "Gene expression changes in progression of cervical neoplasia revealed by microarray analysis of cervical neoplastic keratinocytes". J Cell Physiol. 230 (4): 802–812. doi:10.1002/jcp.24808. PMID 25205602. S2CID 24986454.

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