NXPH1

NXPH1
Identifikatori
Aliasi	NXPH1
Vanjski ID-jevi	OMIM: 604639 MGI: 107492 HomoloGene: 8284 GeneCards: NXPH1
Lokacija gena (čovjek)
Hrom.	Hromosom 7 (čovjek)
Kraj	8,752,961 bp
Lokacija gena (miš)
Hrom.	Hromosom 6 (miš)
Kraj	9,249,032 bp
Obrazac RNK ekspresije
	Više referentnih podataka o ekspresiji
Ortolozi
	30010
	18231
	ENSG00000122584
	ENSMUSG00000046178
	P58417
	Q61200
	NM_152745
	NM_008751
	NP_689958
	NP_032777
	Wikipodaci
Pogledaj/uredi – čovjek	Pogledaj/uredi – miš

Neureksofilin-1 je protein koji je kod ljudi kodiran genom NXPH1.^[5]^[6]

Aminokiselinska sekvenca uredi

Dužina polipeptidnog lanca je 271 aminokiselina, а molekulska težina 31.082 Da.^[7]

C: Cistein

D: Asparaginska kiselina

E: Glutaminska kiselina

F: Fenilalanin

G: Glicin

H: Histidin

I: Izoleucin

K: Lizin

L: Leucin

M: Metionin

N: Asparagin

P: Prolin

Q: Glutamin

R: Arginin

S: Serin

T: Treonin

V: Valin

W: Triptofan

Y: Tirozin

10	20	30	40	50
MQAACWYVLF	LLQPTVYLVT	CANLTNGGKS	ELLKSGSSKS	TLKHIWTESS
KDLSISRLLS	QTFRGKENDT	DLDLRYDTPE	PYSEQDLWDW	LRNSTDLQEP
RPRAKRRPIV	KTGKFKKMFG	WGDFHSNIKT	VKLNLLITGK	IVDHGNGTFS
VYFRHNSTGQ	GNVSVSLVPP	TKIVEFDLAQ	QTVIDAKDSK	SFNCRIEYEK
VDKATKNTLC	NYDPSKTCYQ	EQTQSHVSWL	CSKPFKVICI	YISFYSTDYK
LVQKVCPDYN	YHSDTPYFPS	G

Funkcija uredi

Ovaj gen je član porodice neureksofilina i kodira izlučeni protein s varijabilnim N-terminalnim domenom, visoko konzerviranim N-glikoziliranim centralnim domenom, kratkom veznom regijom i C-terminalnim domenom bogatim cisteinom . Ovaj protein tvori vrlo čvrst kompleks s alfa neureksinima, skupinom proteina koji podstiču prianjanje između dendrita i aksona.^[6]

Reference uredi

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000122584 - Ensembl, maj 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000046178 - Ensembl, maj 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Missler M, Sudhof TC (Jun 1998). "Neurexophilins form a conserved family of neuropeptide-like glycoproteins". J Neurosci. 18 (10): 3630–8. doi:10.1523/JNEUROSCI.18-10-03630.1998. PMC 6793134. PMID 9570794.
^ ^a ^b "Entrez Gene: NXPH1 neurexophilin 1".
^ "UniProt, P58417" (jezik: engleski). Pristupljeno 28. 9. 2021.

Dopunska literatura uredi

Ohira M, Morohashi A, Nakamura Y, et al. (2003). "Neuroblastoma oligo-capping cDNA project: toward the understanding of the genesis and biology of neuroblastoma". Cancer Lett. 197 (1–2): 63–68. doi:10.1016/S0304-3835(03)00085-5. PMID 12880961.
Petrenko AG, Ullrich B, Missler M, et al. (1996). "Structure and evolution of neurexophilin". J. Neurosci. 16 (14): 4360–9. doi:10.1523/JNEUROSCI.16-14-04360.1996. PMC 6578849. PMID 8699246.
Missler M, Hammer RE, Südhof TC (1999). "Neurexophilin binding to alpha-neurexins. A single LNS domain functions as an independently folding ligand-binding unit". J. Biol. Chem. 273 (52): 34716–34723. doi:10.1074/jbc.273.52.34716. PMID 9856994.
Clarris HJ, McKeown S, Key B (2003). "Expression of neurexin ligands, the neuroligins and the neurexophilins, in the developing and adult rodent olfactory bulb". Int. J. Dev. Biol. 46 (4): 649–52. PMID 12141453.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–16903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Scherer SW, Cheung J, MacDonald JR, et al. (2003). "Human chromosome 7: DNA sequence and biology". Science. 300 (5620): 767–772. Bibcode:2003Sci...300..767S. doi:10.1126/science.1083423. PMC 2882961. PMID 12690205.
Hillier LW, Fulton RS, Fulton LA, et al. (2003). "The DNA sequence of human chromosome 7". Nature. 424 (6945): 157–164. Bibcode:2003Natur.424..157H. doi:10.1038/nature01782. PMID 12853948.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–45. doi:10.1038/ng1285. PMID 14702039.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–2127. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000122584 - Ensembl, maj 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000046178 - Ensembl, maj 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9570794-5] Missler M, Sudhof TC (Jun 1998). "Neurexophilins form a conserved family of neuropeptide-like glycoproteins". J Neurosci. 18 (10): 3630–8. doi:10.1523/JNEUROSCI.18-10-03630.1998. PMC 6793134. PMID 9570794.

[entrez-6] "Entrez Gene: NXPH1 neurexophilin 1".

[UniProt-7] "UniProt, P58417" (jezik: engleski). Pristupljeno 28. 9. 2021.

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