NVL (gen)

NVL (gen)
Dostupne strukture
PDB	Pretraga ortologa: PDBe RCSB
Spisak PDB ID kodova
	2X8A
Identifikatori
Aliasi	NVL
Vanjski ID-jevi	OMIM: 602426 MGI: 1914709 HomoloGene: 1902 GeneCards: NVL
Lokacija gena (čovjek)
Hrom.	Hromosom 1 (čovjek)
Kraj	224,330,189 bp
Lokacija gena (miš)
Hrom.	Hromosom 1 (miš)
Kraj	180,971,769 bp
Obrazac RNK ekspresije
	Više referentnih podataka o ekspresiji
Ontologija gena
Molekularna funkcija	• nucleotide binding; • preribosome binding; • GO:0001948, GO:0016582 vezivanje za proteine; • ATP binding; • vezivanje sa RNK; • ATPase activity;
Ćelijska komponenta	• Jedarce; • membrana; • jedro; • telomerase holoenzyme complex; • nukleoplazma; • nuclear exosome (RNase complex);
Biološki proces	• ribosome biogenesis; • positive regulation of telomerase activity; • rRNA processing; • positive regulation of protein binding; • ribosomal large subunit biogenesis; • regulation of protein localization to nucleolus;
	Izvori:Amigo / QuickGO
Ortolozi
	4931
	67459
	ENSG00000143748
	ENSMUSG00000026516
	O15381
	Q9DBY8
	NM_001243146; NM_001243147; NM_002533; NM_206840
	NM_026171
	NP_001230075; NP_001230076; NP_002524; NP_996671
	NP_080447
	Wikipodaci
Pogledaj/uredi – čovjek	Pogledaj/uredi – miš

Proteinoliki jedarni protein sa valozinom jest protein koji je kod ljudi kodiran genom NVL sa hromosoma 1.^[5]^[6]

Aminokiselinska sekvenca

Dužina polipeptidnog lanca je 856 aminokiselina, a molekulska težina 95.051 Da.^[7]

C: Cistein

D: Asparaginska kiselina

E: Glutaminska kiselina

F: Fenilalanin

G: Glicin

H: Histidin

I: Izoleucin

K: Lizin

L: Leucin

M: Metionin

N: Asparagin

P: Prolin

Q: Glutamin

R: Arginin

S: Serin

T: Treonin

V: Valin

W: Triptofan

Y: Tirozin

10	20	30	40	50
MKPRPAGFVD	NKLKQRVIQY	LTSNKCGKYV	DIGVLASDLQ	RVYSIDYGRR
KRNAFRIQVE	KVFSIISSEK	ELKNLTELED	EHLAKRARQG	EEDNEYTESY
SDDDSSMEDY	PDPQSANHMN	SSLLSLYRKG	NPDSVSNTPE	MEQRETTSST
PRISSKTGSI	PLKTPAKDSE	GGWFIDKTPS	VKKDSFFLDL	SCEKSNPKKP
ITEIQDSKDS	SLLESDMKRK	GKLKNKGSKR	KKEDLQEVDG	EIEAVLQKKA
KARGLEFQIS	NVKFEDVGGN	DMTLKEVCKM	LIHMRHPEVY	HHLGVVPPRG
VLLHGPPGCG	KTLLAHAIAG	ELDLPILKVA	APEIVSGVSG	ESEQKLRELF
EQAVSNAPCI	IFIDEIDAIT	PKREVASKDM	ERRIVAQLLT	CMDDLNNVAA
TARVLVIGAT	NRPDSLDPAL	RRAGRFDREI	CLGIPDEASR	ERILQTLCRK
LRLPQAFDFC	HLAHLTPGFV	GADLMALCRE	AAMCAVNRVL	MKLQEQQKKN
PEMEDLPSKG	VQEERLGTEP	TSETQDELQR	LLGLLRDQDP	LSEEQMQGLC
IELNDFIVAL	SSVQPSAKRE	GFVTVPNVTW	ADIGALEDIR	EELTMAILAP
VRNPDQFKAL	GLVTPAGVLL	AGPPGCGKTL	LAKAVANESG	LNFISVKGPE
LLNMYVGESE	RAVRQVFQRA	KNSAPCVIFF	DEVDALCPRR	SDRETGASVR
VVNQLLTEMD	GLEARQQVFI	MAATNRPDII	DPAILRPGRL	DKTLFVGLPP
PADRLAILKT	ITKNGTKPPL	DADVNLEAIA	GDLRCDCYTG	ADLSALVREA
SICALRQEMA	RQKSGNEKGE	LKVSHKHFEE	AFKKVRSSIS	KKDQIMYERL
QESLSR

Reference

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000143748 - Ensembl, maj 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000026516 - Ensembl, maj 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Germain-Lee EL, Obie C, Valle D (Nov 1997). "NVL: a new member of the AAA family of ATPases localized to the nucleus". Genomics. 44 (1): 22–34. doi:10.1006/geno.1997.4856. PMID 9286697.
^ "Entrez Gene: NVL nuclear VCP-like".
^ "UniProt, O15381" (jezik: engleski). Pristupljeno 15. 12. 2017.

Dopunska literatura

Nagahama M, Yamazoe T, Hara Y, et al. (2006). "The AAA-ATPase NVL2 is a component of pre-ribosomal particles that interacts with the DExD/H-box RNA helicase DOB1". Biochem. Biophys. Res. Commun. 346 (3): 1075–82. doi:10.1016/j.bbrc.2006.06.017. PMID 16782053.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Nagahama M, Hara Y, Seki A, et al. (2005). "NVL2 Is a Nucleolar AAA-ATPase that Interacts with Ribosomal Protein L5 through Its Nucleolar Localization Sequence". Mol. Biol. Cell. 15 (12): 5712–23. doi:10.1091/mbc.E04-08-0692. PMC 532049. PMID 15469983.
Leonard D, Ajuh P, Lamond AI, Legerski RJ (2003). "hLodestar/HuF2 interacts with CDC5L and is involved in pre-mRNA splicing". Biochem. Biophys. Res. Commun. 308 (4): 793–801. CiteSeerX 10.1.1.539.8359. doi:10.1016/S0006-291X(03)01486-4. PMID 12927788.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Scherl A, Couté Y, Déon C, et al. (2003). "Functional Proteomic Analysis of Human Nucleolus". Mol. Biol. Cell. 13 (11): 4100–9. doi:10.1091/mbc.E02-05-0271. PMC 133617. PMID 12429849.
Dias Neto E, Correa RG, Verjovski-Almeida S, et al. (2000). "Shotgun sequencing of the human transcriptome with ORF expressed sequence tags". Proc. Natl. Acad. Sci. U.S.A. 97 (7): 3491–6. Bibcode:2000PNAS...97.3491D. doi:10.1073/pnas.97.7.3491. PMC 16267. PMID 10737800.
Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000143748 - Ensembl, maj 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000026516 - Ensembl, maj 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9286697-5] Germain-Lee EL, Obie C, Valle D (Nov 1997). "NVL: a new member of the AAA family of ATPases localized to the nucleus". Genomics. 44 (1): 22–34. doi:10.1006/geno.1997.4856. PMID 9286697.

[entrez-6] "Entrez Gene: NVL nuclear VCP-like".

[UniProt-7] "UniProt, O15381" (jezik: engleski). Pristupljeno 15. 12. 2017.

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