NUCKS1

Jedarni sveprisutni ciklin-ovisni supstrat kazein–kinaze jest protein koji je kod ljudi kodiran genom NUCKS1 sa hromosoma 1.

NUCKS1
Identifikatori
Aliasi	NUCKS1
Vanjski ID-jevi	OMIM: 611912 MGI: 1934811 HomoloGene: 23377 GeneCards: NUCKS1
Lokacija gena (čovjek) Hrom. Hromosom 1 (čovjek) Bend 1q32.1 Početak 205,712,822 bp Kraj 205,750,182 bp
Lokacija gena (miš) Hrom. Hromosom 1 (miš) Bend 1|1 E4 Početak 131,838,272 bp Kraj 131,864,059 bp
Obrazac RNK ekspresije Više referentnih podataka o ekspresiji
Ontologija gena Molekularna funkcija • GO:0001077, GO:0001212, GO:0001213, GO:0001211, GO:0001205 DNA-binding transcription activator activity, RNA polymerase II-specific • transcription factor binding • chromatin binding • double-stranded DNA binding • single-stranded DNA binding • vezivanje sa RNK Ćelijska komponenta • citoplazma • jedro • Hromatin • Jedarce Biološki proces • GO:1903106 positive regulation of insulin receptor signaling pathway • transcription by RNA polymerase II • glucose homeostasis • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II • interstrand cross-link repair • regulation of DNA strand elongation • cellular response to X-ray • regulation of DNA replication • Konverzija gena • double-strand break repair via homologous recombination • GO:0044324, GO:0003256, GO:1901213, GO:0046019, GO:0046020, GO:1900094, GO:0061216, GO:0060994, GO:1902064, GO:0003258, GO:0072212 regulation of transcription by RNA polymerase II • replication fork processing • cellular glucose homeostasis • GO:0031497, GO:0006336, GO:0034724, GO:0001301, GO:0007580, GO:0034652, GO:0010847 chromatin organization • GO:1903104 regulation of insulin receptor signaling pathway Izvori:Amigo / QuickGO
Ortolozi
Vrste	Čovjek	Miš
Entrez	64710	98415
Ensembl	ENSG00000069275	ENSMUSG00000026434
UniProt	Q9H1E3	Q80XU3
RefSeq (mRNK)	NM_022731	NM_001145804 NM_175294
RefSeq (bjelančevina)	NP_073568	NP_001139276 NP_780503
Lokacija (UCSC)	Chr 1: 205.71 – 205.75 Mb	Chr 1: 131.84 – 131.86 Mb
PubMed pretraga
Wikipodaci
Pogledaj/uredi – čovjek Pogledaj/uredi – miš

Aminokiselinska sekvenca

Dužina polipeptidnog lanca je 243 aminokiseline, a molekulska težina 27.296 Da.

• C: Cistein
• D: Asparaginska kiselina
• E: Glutaminska kiselina
• F: Fenilalanin
• G: Glicin
• H: Histidin
• I: Izoleucin
• K: Lizin
• L: Leucin
• M: Metionin
• N: Asparagin
• P: Prolin
• Q: Glutamin
• R: Arginin
• S: Serin
• T: Treonin
• V: Valin
• W: Triptofan
• Y: Tirozin

10		20		30		40		50
MSRPVRNRKV		VDYSQFQESD		DADEDYGRDS		GPPTKKIRSS		PREAKNKRRS
GKNSQEDSED		SEDKDVKTKK		DDSHSAEDSE		DEKEDHKNVR		QQRQAASKAA
SKQREMLMED		VGSEEEQEEE		DEAPFQEKDS		GSDEDFLMED		DDDSDYGSSK
KKNKKMVKKS		KPERKEKKMP		KPRLKATVTP		SPVKGKGKVG		RPTASKASKE
KTPSPKEEDE		EPESPPEKKT		STSPPPEKSG		DEGSEDEAPS		GED

Dopunska literatura

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• Grundt K, Skjeldal L, Anthonsen HW, et al. (2002). "A putative DNA-binding domain in the NUCKS protein". Arch. Biochem. Biophys. 407 (2): 168–75. doi:10.1016/S0003-9861(02)00513-1. PMID 12413487.
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• Grundt K, Haga IV, Aleporou-Marinou V, et al. (2004). "Characterisation of the NUCKS gene on human chromosome 1q32.1 and the presence of a homologous gene in different species". Biochem. Biophys. Res. Commun. 323 (3): 796–801. doi:10.1016/j.bbrc.2004.08.153. PMID 15381070.
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• Gevaert K, Staes A, Van Damme J, et al. (2006). "Global phosphoproteome analysis on human HepG2 hepatocytes using reversed-phase diagonal LC". Proteomics. 5 (14): 3589–99. doi:10.1002/pmic.200401217. PMID 16097034. S2CID 895879.
• Beausoleil SA, Villén J, Gerber SA, et al. (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nat. Biotechnol. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID 16964243. S2CID 14294292.
• Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.
• Grundt K, Haga IV, Huitfeldt HS, Ostvold AC (2007). "Identification and characterization of two putative nuclear localization signals (NLS) in the DNA-binding protein NUCKS". Biochim. Biophys. Acta. 1773 (9): 1398–406. doi:10.1016/j.bbamcr.2007.05.013. PMID 17604136.