NOD1
Nukleotidnovezujući protein 1 sa domenom oligomerizacije (NOD1) jest protein koji je kod ljudi kodiran genom NOD1 sa p kraka hromosoma 7.[5][6] Prepoznaje bakterijske molekule i stimulira imunsku reakciju.[7]
Aminokiselinska sekvenca
urediDužina polipeptidnog lanca je 953 aminokiseline, a molekulska težina 107.691 Da.[5]
10 | 20 | 30 | 40 | 50 | ||||
---|---|---|---|---|---|---|---|---|
MEEQGHSEME | IIPSESHPHI | QLLKSNRELL | VTHIRNTQCL | VDNLLKNDYF | ||||
SAEDAEIVCA | CPTQPDKVRK | ILDLVQSKGE | EVSEFFLYLL | QQLADAYVDL | ||||
RPWLLEIGFS | PSLLTQSKVV | VNTDPVSRYT | QQLRHHLGRD | SKFVLCYAQK | ||||
EELLLEEIYM | DTIMELVGFS | NESLGSLNSL | ACLLDHTTGI | LNEQGETIFI | ||||
LGDAGVGKSM | LLQRLQSLWA | TGRLDAGVKF | FFHFRCRMFS | CFKESDRLCL | ||||
QDLLFKHYCY | PERDPEEVFA | FLLRFPHVAL | FTFDGLDELH | SDLDLSRVPD | ||||
SSCPWEPAHP | LVLLANLLSG | KLLKGASKLL | TARTGIEVPR | QFLRKKVLLR | ||||
GFSPSHLRAY | ARRMFPERAL | QDRLLSQLEA | NPNLCSLCSV | PLFCWIIFRC | ||||
FQHFRAAFEG | SPQLPDCTMT | LTDVFLLVTE | VHLNRMQPSS | LVQRNTRSPV | ||||
ETLHAGRDTL | CSLGQVAHRG | MEKSLFVFTQ | EEVQASGLQE | RDMQLGFLRA | ||||
LPELGPGGDQ | QSYEFFHLTL | QAFFTAFFLV | LDDRVGTQEL | LRFFQEWMPP | ||||
AGAATTSCYP | PFLPFQCLQG | SGPAREDLFK | NKDHFQFTNL | FLCGLLSKAK | ||||
QKLLRHLVPA | AALRRKRKAL | WAHLFSSLRG | YLKSLPRVQV | ESFNQVQAMP | ||||
TFIWMLRCIY | ETQSQKVGQL | AARGICANYL | KLTYCNACSA | DCSALSFVLH | ||||
HFPKRLALDL | DNNNLNDYGV | RELQPCFSRL | TVLRLSVNQI | TDGGVKVLSE | ||||
ELTKYKIVTY | LGLYNNQITD | VGARYVTKIL | DECKGLTHLK | LGKNKITSEG | ||||
GKYLALAVKN | SKSISEVGMW | GNQVGDEGAK | AFAEALRNHP | SLTTLSLASN | ||||
GISTEGGKSL | ARALQQNTSL | EILWLTQNEL | NDEVAESLAE | MLKVNQTLKH | ||||
LWLIQNQITA | KGTAQLADAL | QSNTGITEIC | LNGNLIKPEE | AKVYEDEKRI | ||||
ICF |
Funkcija
urediNOD1 protein sadrži domen regrutacije kaspaze (CARD). NOD1 je član porodice proteina nodolikih receptota i blizak je srodnik NOD2. NOD1 je unutarćrlijski receptor prepoznavanja uzoraka, koji je po strukturi sličan otpornim proteinima biljaka, i posreduje urođeni i stečeni imunitet, prepoznavanjem molekula koji sadrže dio D-glutamil-mezo-diaminopimelne kiseline (iE-DAP), uključujući bakterijski peptidoglikan. Nod1 stupa u interakciju sa RIPK2 preko Card domen|CARD-a]] obiju molekula (Pogledajte strukturu NOD1 CARD na desnom panelu). Stimulacija NOD1 molekulama koji sadrže iE-DAP rezultira aktivacijom faktora transkripcije NF-κB.
Reference
uredi- ^ a b c GRCh38: Ensembl release 89: ENSG00000106100 - Ensembl, maj 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000038058 - Ensembl, maj 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ a b Bertin J, Nir WJ, Fischer CM, Tayber OV, Errada PR, Grant JR, Keilty JJ, Gosselin ML, Robison KE, Wong GH, Glucksmann MA, DiStefano PS (maj 1999). "Human CARD4 protein is a novel CED-4/Apaf-1 cell death family member that activates NF-kappaB". The Journal of Biological Chemistry. 274 (19): 12955–8. doi:10.1074/jbc.274.19.12955. PMID 10224040.
- ^ Inohara N, Koseki T, del Peso L, Hu Y, Yee C, Chen S, Carrio R, Merino J, Liu D, Ni J, Núñez G (maj 1999). "Nod1, an Apaf-1-like activator of caspase-9 and nuclear factor-kappaB". The Journal of Biological Chemistry. 274 (21): 14560–7. doi:10.1074/jbc.274.21.14560. PMID 10329646.
- ^ Mahla RS, Reddy MC, Prasad DV, Kumar H (septembar 2013). "Sweeten PAMPs: Role of Sugar Complexed PAMPs in Innate Immunity and Vaccine Biology". Frontiers in Immunology. 4: 248. doi:10.3389/fimmu.2013.00248. PMC 3759294. PMID 24032031.
Dopunska literatura
uredi- Martinon F, Tschopp J (august 2005). "NLRs join TLRs as innate sensors of pathogens". Trends in Immunology. 26 (8): 447–54. doi:10.1016/j.it.2005.06.004. PMID 15967716.
- Strober W, Murray PJ, Kitani A, Watanabe T (januar 2006). "Signalling pathways and molecular interactions of NOD1 and NOD2". Nature Reviews. Immunology. 6 (1): 9–20. doi:10.1038/nri1747. PMID 16493424. S2CID 33505741.
- Inohara N, Koseki T, Lin J, del Peso L, Lucas PC, Chen FF, Ogura Y, Núñez G (septembar 2000). "An induced proximity model for NF-kappa B activation in the Nod1/RICK and RIP signaling pathways". The Journal of Biological Chemistry. 275 (36): 27823–31. doi:10.1074/jbc.M003415200. PMID 10880512.
- Inohara N, Ogura Y, Chen FF, Muto A, Nuñez G (januar 2001). "Human Nod1 confers responsiveness to bacterial lipopolysaccharides". The Journal of Biological Chemistry. 276 (4): 2551–4. doi:10.1074/jbc.M009728200. PMID 11058605.
- Chu ZL, Pio F, Xie Z, Welsh K, Krajewska M, Krajewski S, Godzik A, Reed JC (mart 2001). "A novel enhancer of the Apaf1 apoptosome involved in cytochrome c-dependent caspase activation and apoptosis". The Journal of Biological Chemistry. 276 (12): 9239–45. doi:10.1074/jbc.M006309200. PMID 11113115.
- Yoo NJ, Park WS, Kim SY, Reed JC, Son SG, Lee JY, Lee SH (decembar 2002). "Nod1, a CARD protein, enhances pro-interleukin-1beta processing through the interaction with pro-caspase-1". Biochemical and Biophysical Research Communications. 299 (4): 652–8. doi:10.1016/S0006-291X(02)02714-6. PMID 12459189.
- Matsuda A, Suzuki Y, Honda G, Muramatsu S, Matsuzaki O, Nagano Y, Doi T, Shimotohno K, Harada T, Nishida E, Hayashi H, Sugano S (maj 2003). "Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways". Oncogene. 22 (21): 3307–18. doi:10.1038/sj.onc.1206406. PMID 12761501.
- Stehlik C, Hayashi H, Pio F, Godzik A, Reed JC (august 2003). "CARD6 is a modulator of NF-kappa B activation by Nod1- and Cardiak-mediated pathways". The Journal of Biological Chemistry. 278 (34): 31941–9. doi:10.1074/jbc.M300009200. PMID 12775719.
- Girardin SE, Boneca IG, Carneiro LA, Antignac A, Jéhanno M, Viala J, Tedin K, Taha MK, Labigne A, Zähringer U, Coyle AJ, DiStefano PS, Bertin J, Sansonetti PJ, Philpott DJ (juni 2003). "Nod1 detects a unique muropeptide from gram-negative bacterial peptidoglycan". Science. 300 (5625): 1584–7. Bibcode:2003Sci...300.1584G. doi:10.1126/science.1084677. PMID 12791997. S2CID 1320864.
- Hisamatsu T, Suzuki M, Podolsky DK (august 2003). "Interferon-gamma augments CARD4/NOD1 gene and protein expression through interferon regulatory factor-1 in intestinal epithelial cells". The Journal of Biological Chemistry. 278 (35): 32962–8. doi:10.1074/jbc.M304355200. PMID 12813035.
- Girardin SE, Travassos LH, Hervé M, Blanot D, Boneca IG, Philpott DJ, Sansonetti PJ, Mengin-Lecreulx D (oktobar 2003). "Peptidoglycan molecular requirements allowing detection by Nod1 and Nod2". The Journal of Biological Chemistry. 278 (43): 41702–8. doi:10.1074/jbc.M307198200. PMID 12871942.
- Kim JG, Lee SJ, Kagnoff MF (mart 2004). "Nod1 is an essential signal transducer in intestinal epithelial cells infected with bacteria that avoid recognition by toll-like receptors". Infection and Immunity. 72 (3): 1487–95. doi:10.1128/IAI.72.3.1487-1495.2004. PMC 356064. PMID 14977954.
- Damiano JS, Oliveira V, Welsh K, Reed JC (juli 2004). "Heterotypic interactions among NACHT domains: implications for regulation of innate immune responses". The Biochemical Journal. 381 (Pt 1): 213–9. doi:10.1042/BJ20031506. PMC 1133779. PMID 15107016.
Vanjski linkovi
uredi- NOD1 lokacija ljudskog genoma UCSC Genome Browser.
NOD1 detalji ljudskog genoma u UCSC Genome Browser.