Nukleotidnovezujući protein 1 sa domenom oligomerizacije (NOD1) jest protein koji je kod ljudi kodiran genom NOD1 sa p kraka hromosoma 7.[5][6] Prepoznaje bakterijske molekule i stimulira imunsku reakciju.[7]

NOD1
Dostupne strukture
PDBPretraga ortologa: PDBe RCSB
Spisak PDB ID kodova

2B1W, 2DBD, 2NSN, 2NZ7, 4E9M, 4JQW

Identifikatori
AliasiNOD1
Vanjski ID-jeviOMIM: 605980 MGI: 1341839 HomoloGene: 4440 GeneCards: NOD1
Lokacija gena (čovjek)
Hromosom 7 (čovjek)
Hrom.Hromosom 7 (čovjek)[1]
Hromosom 7 (čovjek)
Genomska lokacija za NOD1
Genomska lokacija za NOD1
Bend7p14.3Početak30,424,527 bp[1]
Kraj30,478,784 bp[1]
Lokacija gena (miš)
Hromosom 6 (miš)
Hrom.Hromosom 6 (miš)[2]
Hromosom 6 (miš)
Genomska lokacija za NOD1
Genomska lokacija za NOD1
Bend6|6 B3Početak54,900,934 bp[2]
Kraj54,949,597 bp[2]
Obrazac RNK ekspresije
Više referentnih podataka o ekspresiji
Ontologija gena
Molekularna funkcija nucleotide binding
protein homodimerization activity
GO:0001948, GO:0016582 vezivanje za proteine
peptidoglycan binding
vezivanje identičnih proteina
cysteine-type endopeptidase activator activity involved in apoptotic process
CARD domain binding
ATP binding
GO:0032403 protein-containing complex binding
Ćelijska komponenta citoplazma
citosol
membrana
ćelijska membrana
basolateral plasma membrane
apical plasma membrane
Biološki proces regulation of apoptotic process
defense response
detection of biotic stimulus
GO:0007243 intracellular signal transduction
positive regulation of cell death
immune system process
positive regulation of JNK cascade
positive regulation of xenophagy
positive regulation of NIK/NF-kappaB signaling
cellular response to muramyl dipeptide
JNK cascade
positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
positive regulation of dendritic cell antigen processing and presentation
positive regulation of nitric-oxide synthase activity
defense response to bacterium
positive regulation of NF-kappaB transcription factor activity
protein complex oligomerization
detection of bacterium
positive regulation of interleukin-1 beta production
positive regulation of ERK1 and ERK2 cascade
positive regulation of interleukin-6 production
positive regulation of tumor necrosis factor production
positive regulation of I-kappaB kinase/NF-kappaB signaling
inflammatory response
activation of cysteine-type endopeptidase activity involved in apoptotic process
nucleotide-binding oligomerization domain containing signaling pathway
GO:0072468 Transdukcija signala
positive regulation of stress-activated MAPK cascade
GO:0051637 defense response to Gram-positive bacterium
GO:0097285 apoptoza
Urođeni imunski sistem
interleukin-1-mediated signaling pathway
Izvori:Amigo / QuickGO
Ortolozi
VrsteČovjekMiš
Entrez
Ensembl
UniProt
RefSeq (mRNK)

NM_006092
NM_001354849

NM_001171007
NM_172729

RefSeq (bjelančevina)

NP_006083
NP_001341778

NP_001164478
NP_766317

Lokacija (UCSC)Chr 7: 30.42 – 30.48 MbChr 6: 54.9 – 54.95 Mb
PubMed pretraga[3][4]
Wikipodaci
Pogledaj/uredi – čovjekPogledaj/uredi – miš

Aminokiselinska sekvenca

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Dužina polipeptidnog lanca je 953 aminokiseline, a molekulska težina 107.691 Da.[5]

1020304050
MEEQGHSEMEIIPSESHPHIQLLKSNRELLVTHIRNTQCLVDNLLKNDYF
SAEDAEIVCACPTQPDKVRKILDLVQSKGEEVSEFFLYLLQQLADAYVDL
RPWLLEIGFSPSLLTQSKVVVNTDPVSRYTQQLRHHLGRDSKFVLCYAQK
EELLLEEIYMDTIMELVGFSNESLGSLNSLACLLDHTTGILNEQGETIFI
LGDAGVGKSMLLQRLQSLWATGRLDAGVKFFFHFRCRMFSCFKESDRLCL
QDLLFKHYCYPERDPEEVFAFLLRFPHVALFTFDGLDELHSDLDLSRVPD
SSCPWEPAHPLVLLANLLSGKLLKGASKLLTARTGIEVPRQFLRKKVLLR
GFSPSHLRAYARRMFPERALQDRLLSQLEANPNLCSLCSVPLFCWIIFRC
FQHFRAAFEGSPQLPDCTMTLTDVFLLVTEVHLNRMQPSSLVQRNTRSPV
ETLHAGRDTLCSLGQVAHRGMEKSLFVFTQEEVQASGLQERDMQLGFLRA
LPELGPGGDQQSYEFFHLTLQAFFTAFFLVLDDRVGTQELLRFFQEWMPP
AGAATTSCYPPFLPFQCLQGSGPAREDLFKNKDHFQFTNLFLCGLLSKAK
QKLLRHLVPAAALRRKRKALWAHLFSSLRGYLKSLPRVQVESFNQVQAMP
TFIWMLRCIYETQSQKVGQLAARGICANYLKLTYCNACSADCSALSFVLH
HFPKRLALDLDNNNLNDYGVRELQPCFSRLTVLRLSVNQITDGGVKVLSE
ELTKYKIVTYLGLYNNQITDVGARYVTKILDECKGLTHLKLGKNKITSEG
GKYLALAVKNSKSISEVGMWGNQVGDEGAKAFAEALRNHPSLTTLSLASN
GISTEGGKSLARALQQNTSLEILWLTQNELNDEVAESLAEMLKVNQTLKH
LWLIQNQITAKGTAQLADALQSNTGITEICLNGNLIKPEEAKVYEDEKRI
ICF

Funkcija

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NOD1 protein sadrži domen regrutacije kaspaze (CARD). NOD1 je član porodice proteina nodolikih receptota i blizak je srodnik NOD2. NOD1 je unutarćrlijski receptor prepoznavanja uzoraka, koji je po strukturi sličan otpornim proteinima biljaka, i posreduje urođeni i stečeni imunitet, prepoznavanjem molekula koji sadrže dio D-glutamil-mezo-diaminopimelne kiseline (iE-DAP), uključujući bakterijski peptidoglikan. Nod1 stupa u interakciju sa RIPK2 preko Card domen|CARD-a]] obiju molekula (Pogledajte strukturu NOD1 CARD na desnom panelu). Stimulacija NOD1 molekulama koji sadrže iE-DAP rezultira aktivacijom faktora transkripcije NF-κB.

Reference

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000106100 - Ensembl, maj 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000038058 - Ensembl, maj 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b Bertin J, Nir WJ, Fischer CM, Tayber OV, Errada PR, Grant JR, Keilty JJ, Gosselin ML, Robison KE, Wong GH, Glucksmann MA, DiStefano PS (maj 1999). "Human CARD4 protein is a novel CED-4/Apaf-1 cell death family member that activates NF-kappaB". The Journal of Biological Chemistry. 274 (19): 12955–8. doi:10.1074/jbc.274.19.12955. PMID 10224040.
  6. ^ Inohara N, Koseki T, del Peso L, Hu Y, Yee C, Chen S, Carrio R, Merino J, Liu D, Ni J, Núñez G (maj 1999). "Nod1, an Apaf-1-like activator of caspase-9 and nuclear factor-kappaB". The Journal of Biological Chemistry. 274 (21): 14560–7. doi:10.1074/jbc.274.21.14560. PMID 10329646.
  7. ^ Mahla RS, Reddy MC, Prasad DV, Kumar H (septembar 2013). "Sweeten PAMPs: Role of Sugar Complexed PAMPs in Innate Immunity and Vaccine Biology". Frontiers in Immunology. 4: 248. doi:10.3389/fimmu.2013.00248. PMC 3759294. PMID 24032031.

Dopunska literatura

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Vanjski linkovi

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NOD1 detalji ljudskog genoma u UCSC Genome Browser.

Šablon:Nodoliki receptori