NLRP8

NLRP8, skraćenica za porodicu NOD-likih receptora pirinskog domena sa proreinom 8, je unutarćelijski protein koji se eksprimira u jajnicima, sjemenicima ipreimplantcijskim embrionima sisara. To jest protein koji je kod ljudi kodiran genom NLRP8 sa q kraka hromosoma 19. Također je poznat kao NALP8, NOD16, PAN4 i CLR19.2, i jedan je od 14 pirinskih domena koji sadrže članove porodice NOD-u sličnih citoplazmatskih receptora.

NLRP8
Identifikatori
Aliasi	NLRP8
Vanjski ID-jevi	OMIM: 609659 HomoloGene: 82360 GeneCards: NLRP8
Lokacija gena (čovjek) Hrom. Hromosom 19 (čovjek) Bend 19q13.43 Početak 55,947,832 bp Kraj 55,988,629 bp
Ontologija gena Molekularna funkcija • nucleotide binding • ATP binding • molekularna funkcija Ćelijska komponenta • citoplazma • ćelijska komponenta Biološki proces • neuron death Izvori:Amigo / QuickGO
Ortolozi
Vrste	Čovjek	Miš
Entrez	126205	n/a
Ensembl	ENSG00000179709	n/a
UniProt	Q86W28	n/a
RefSeq (mRNK)	NM_176811 NM_001317000	n/a
RefSeq (bjelančevina)	NP_001303929 NP_789781	n/a
Lokacija (UCSC)	Chr 19: 55.95 – 55.99 Mb	n/a
PubMed pretraga		n/a
Wikipodaci
Pogledaj/uredi – čovjek

Aminokiselinska sekvenca

Dužina polipeptidnog lanca je 1.048 aminokiselina, a molekulska težina 119.430 Da.

• C: Cistein
• D: Asparaginska kiselina
• E: Glutaminska kiselina
• F: Fenilalanin
• G: Glicin
• H: Histidin
• I: Izoleucin
• K: Lizin
• L: Leucin
• M: Metionin
• N: Asparagin
• P: Prolin
• Q: Glutamin
• R: Arginin
• S: Serin
• T: Treonin
• V: Valin
• W: Triptofan
• Y: Tirozin

10		20		30		40		50
MSDVNPPSDT		PIPFSSSSTH		SSHIPPWTFS		CYPGSPCENG		VMLYMRNVSH
EELQRFKQLL		LTELSTGTMP		ITWDQVETAS		WAEVVHLLIE		RFPGRRAWDV
TSNIFAIMNC		DKMCVVVRRE		INAILPTLEP		EDLNVGETQV		NLEEGESGKI
RRYKSNVMEK		FFPIWDITTW		PGNQRDFFYQ		GVHRHEEYLP		CLLLPKRPQG
RQPKTVAIQG		APGIGKTILA		KKVMFEWARN		KFYAHKRWCA		FYFHCQEVNQ
TTDQSFSELI		EQKWPGSQDL		VSKIMSKPDQ		LLLLLDGFEE		LTSTLIDRLE
DLSEDWRQKL		PGSVLLSSLL		SKTMLPEATL		LIMIRFTSWQ		TCKPLLKCPS
LVTLPGFNTM		EKIKYFQMYF		GHTEEGDQVL		SFAMENTILF		SMCRVPVVCW
MVCSGLKQQM		ERGNNLTQSC		PNATSVFVRY		ISSLFPTRAE		NFSRKIHQAQ
LEGLCHLAAD		SMWHRKWVLG		KEDLEEAKLD		QTGVTAFLGM		SILRRIAGEE
DHYVFTLVTF		QEFFAALFYV		LCFPQRLKNF		HVLSHVNIQR		LIASPRGSKS
YLSHMGLFLF		GFLNEACASA		VEQSFQCKVS		FGNKRKLLKV		IPLLHKCDPP
SPGSGVPQLF		YCLHEIREEA		FVSQALNDYH		KVVLRIGNNK		EVQVSAFCLK
RCQYLHEVEL		TVTLNFMNVW		KLSSSSHPGS		EAPESNGLHR		WWQDLCSVFA
TNDKLEVLTM		TNSVLGPPFL		KALAAALRHP		QCKLQKLLLR		RVNSTMLNQD
LIGVLTGNQH		LRYLEIQHVE		VESKAVKLLC		RVLRSPRCRL		QCLRLEDCLA
TPRIWTDLGN		NLQGNGHLKT		LILRKNSLEN		CGAYYLSVAQ		LERLSIENCN
LTQLTCESLA		SCLRQSKMLT		HLSLAENALK		DEGAKHIWNA		LPHLRCPLQR
LVLRKCDLTF		NCCQDMISAL		CKNKTLKSLD		LSFNSLKDDG		VILLCEALKN
PDCTLQILEL		ENCLFTSICC		QAMASMLRKN		QHLRHLDLSK		NAIGVYGILT
LCEAFSSQKK		REEVIFCIPA		WTRITSFSPT		PHPPDFTGKS		DCLSQINP

Dopunska literatura

• Enjuanes A, Benavente Y, Bosch F, et al. (2008). "Genetic variants in apoptosis and immunoregulation-related genes are associated with risk of chronic lymphocytic leukemia". Cancer Res. 68 (24): 10178–86. doi:10.1158/0008-5472.CAN-08-2221. PMID 19074885.
• Inohara N, Nuñez G (2003). "NODs: intracellular proteins involved in inflammation and apoptosis". Nat. Rev. Immunol. 3 (5): 371–82. doi:10.1038/nri1086. PMID 12766759. S2CID 8088987.
• Tschopp J, Martinon F, Burns K (2003). "NALPs: a novel protein family involved in inflammation". Nat. Rev. Mol. Cell Biol. 4 (2): 95–104. doi:10.1038/nrm1019. PMID 12563287. S2CID 31417018.