NLRP6

NLRP6
Identifikatori
Aliasi	NLRP6
Vanjski ID-jevi	OMIM: 609650 MGI: 2141990 HomoloGene: 15881 GeneCards: NLRP6
Lokacija gena (čovjek)
Hrom.	Hromosom 11 (čovjek)
Kraj	285,388 bp
Lokacija gena (miš)
Hrom.	Hromosom 7 (miš)
Kraj	140,509,105 bp
Ontologija gena
Molekularna funkcija	• nucleotide binding; • vasopressin receptor activity; • ATP binding;
Ćelijska komponenta	• citoplazma; • Jedarna membrana; • membrana; • ćelijska membrana; • Inflamasom; • jedro;
Biološki proces	• response to bacterium; • immune system process; • Zarastanje rana; • regulation of mucus secretion; • negative regulation of I-kappaB kinase/NF-kappaB signaling; • negative regulation of immune response; • regulation of autophagy; • negative regulation of toll-like receptor signaling pathway; • negative regulation of inflammatory response to antigenic stimulus; • regulation of inflammatory response; • negative regulation of MAPK cascade; • negative regulation of ERK1 and ERK2 cascade; • Urođeni imunski sistem; • inflammatory response; • G protein-coupled receptor signaling pathway;
	Izvori:Amigo / QuickGO
Ortolozi
	171389
	101613
	ENSG00000174885
	ENSMUSG00000038745
	P59044
	Q91WS2
	NM_001276700; NM_138329
	NM_001081389; NM_133946
	NP_001263629; NP_612202
	NP_598707
	Wikipodaci
Pogledaj/uredi – čovjek	Pogledaj/uredi – miš

NLRP6, skraćeno za NOD-liki receptor porodice pirinski domen sa proteinom 6, je unutarćelijski protein koji ima ulogu u imunskom sistemu. Također je poznat kao NALP6, PYPAF5, PAN3 i CLR11.4, i jedan je od 14 pirinskih domena koji sadrže članove porodice receptora sličnih NOD receptor za prepoznavanje uzoraka. Kao i kod nekoliko drugih receptora sličnih NOD-u, uloga NLRP6 u imunosti povezana je sa njegovom sposobnošću da reguliše aktivnost kaspaze-1 i NF-κB.To jest protein koji je kod ljudi kodiran genom NLRP6 sa hromosoma 11.^[5]

Aminokiselinska sekvenca

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000174885 - Ensembl, maj 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000038745 - Ensembl, maj 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ ^a ^b Grenier JM, Wang L, Manji GA, et al. (oktobar 2002). "Functional screening of five PYPAF family members identifies PYPAF5 as a novel regulator of NF-kappaB and caspase-1". FEBS Lett. 530 (1–3): 73–8. doi:10.1016/S0014-5793(02)03416-6. PMID 12387869. S2CID 25023390.