TMEM48
(Preusmjereno sa NDC1)
Nukleoporin NDC1 jest protein koji je kod ljudi kodiran genom TMEM48 sa hromosoma 1.[5][6][7]
Aminokiselinska sekvenca
urediDužina polipeptidnog lanca je 674 aminokiseline, a molekulska težina 76.305 Da.[8].
10 | 20 | 30 | 40 | 50 | ||||
---|---|---|---|---|---|---|---|---|
MATAVSRPCA | GRSRDILWRV | LGWRIVASIV | WSVLFLPICT | TVFIIFSRID | ||||
LFHPIQWLSD | SFSDLYSSYV | IFYFLLLSVV | IIIISIFNVE | FYAVVPSIPC | ||||
SRLALIGKII | HPQQLMHSFI | HAAMGMVMAW | CAAVITQGQY | SFLVVPCTGT | ||||
NSFGSPAAQT | CLNEYHLFFL | LTGAFMGYSY | SLLYFVNNMN | YLPFPIIQQY | ||||
KFLRFRRSLL | LLVKHSCVES | LFLVRNFCIL | YYFLGYIPKA | WISTAMNLHI | ||||
DEQVHRPLDT | VSGLLNLSLL | YHVWLCGVFL | LTTWYVSWIL | FKIYATEAHV | ||||
FPVQPPFAEG | SDECLPKVLN | SNPPPIIKYL | ALQDLMLLSQ | YSPSRRQEVF | ||||
SLSQPGGHPH | NWTAISRECL | NLLNGMTQKL | ILYQEAAATN | GRVSSSYPVE | ||||
PKKLNSPEET | AFQTPKSSQM | PRPSVPPLVK | TSLFSSKLST | PDVVSPFGTP | ||||
FGSSVMNRMA | GIFDVNTCYG | SPQSPQLIRR | GPRLWTSASD | QQMTEFSNPS | ||||
PSTSISAEGK | TMRQPSVIYS | WIQNKREQIK | NFLSKRVLIM | YFFSKHPEAS | ||||
IQAVFSDAQM | HIWALEGLSH | LVAASFTEDR | FGVVQTTLPA | ILNTLLTLQE | ||||
AVDKYFKLPH | ASSKPPRISG | SLVDTSYKTL | RFAFRASLKT | AIYRITTTFG | ||||
EHLNAVQASA | EHQKRLQQFL | EFKE |
Funkcija
urediNukleoporin NDC1 sidri aladin za kompleks jedarnih pora.[9]
Reference
uredi- ^ a b c GRCh38: Ensembl release 89: ENSG00000058804 - Ensembl, maj 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000028614 - Ensembl, maj 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Lau CK, Delmar VA, Forbes DJ (Aug 2006). "Topology of yeast Ndc1p: predictions for the human NDC1/NET3 homologue". Anat Rec A. 288 (7): 681–94. doi:10.1002/ar.a.20335. PMC 3049984. PMID 16779818.
- ^ Schirmer EC, Florens L, Guan T, Yates JR 3rd, Gerace L (Sep 2003). "Nuclear membrane proteins with potential disease links found by subtractive proteomics". Science. 301 (5638): 1380–2. Bibcode:2003Sci...301.1380S. doi:10.1126/science.1088176. PMID 12958361. S2CID 23832536.
- ^ "Entrez Gene: TMEM48 transmembrane protein 48".
- ^ "UniProt, Q9BTX1" (jezik: англ.). Pristupljeno 28 серпня 2017. Provjerite vrijednost datuma u parametru:
|access-date=
(pomoć)CS1 održavanje: nepoznati jezik (link) - ^ Kind, Barbara; Koehler, Katrin; Lorenz, Mike; Huebner, Angela (decembar 2009). "The nuclear pore complex protein ALADIN is anchored via NDC1 but not via POM121 and GP210 in the nuclear envelope". Biochemical and Biophysical Research Communications. 390 (2): 205–210. doi:10.1016/j.bbrc.2009.09.080. PMID 19782045.
Dopunska literatura
uredi- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Nousiainen M, Silljé HH, Sauer G, et al. (2006). "Phosphoproteome analysis of the human mitotic spindle". Proc. Natl. Acad. Sci. U.S.A. 103 (14): 5391–6. Bibcode:2006PNAS..103.5391N. doi:10.1073/pnas.0507066103. PMC 1459365. PMID 16565220.
- Mansfeld J, Güttinger S, Hawryluk-Gara LA, et al. (2006). "The conserved transmembrane nucleoporin NDC1 is required for nuclear pore complex assembly in vertebrate cells". Mol. Cell. 22 (1): 93–103. doi:10.1016/j.molcel.2006.02.015. PMID 16600873.
- Stavru F, Hülsmann BB, Spang A, et al. (2006). "NDC1: a crucial membrane-integral nucleoporin of metazoan nuclear pore complexes" (PDF). J. Cell Biol. 173 (4): 509–19. doi:10.1083/jcb.200601001. PMC 2063861. PMID 16702233.
- Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature. 441 (7091): 315–21. Bibcode:2006Natur.441..315G. doi:10.1038/nature04727. PMID 16710414.
- Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.