TMEM48

(Preusmjereno sa NDC1)

Nukleoporin NDC1 jest protein koji je kod ljudi kodiran genom TMEM48 sa hromosoma 1.[5][6][7]

TMEM48
Identifikatori
AliasiNDC1
Vanjski ID-jeviOMIM: 610115 MGI: 1920037 HomoloGene: 41224 GeneCards: NDC1
Lokacija gena (čovjek)
Hromosom 1 (čovjek)
Hrom.Hromosom 1 (čovjek)[1]
Hromosom 1 (čovjek)
Genomska lokacija za TMEM48
Genomska lokacija za TMEM48
Bend1p32.3Početak53,765,478 bp[1]
Kraj53,838,463 bp[1]
Lokacija gena (miš)
Hromosom 4 (miš)
Hrom.Hromosom 4 (miš)[2]
Hromosom 4 (miš)
Genomska lokacija za TMEM48
Genomska lokacija za TMEM48
Bend4|4 C7Početak107,224,981 bp[2]
Kraj107,273,543 bp[2]
Obrazac RNK ekspresije
Više referentnih podataka o ekspresiji
Ontologija gena
Molekularna funkcija GO:0005487 structural constituent of nuclear pore
Ćelijska komponenta citoplazma
integral component of membrane
Jedarna membrana
nuclear envelope
membrana
ćelijska membrana
jedrova pora
actin cytoskeleton
jedro
Polarno tijelo diobenog vretena
nuclear pore transmembrane ring
host cell
Biološki proces mRNA transport
nuclear pore complex assembly
viral transcription
protein sumoylation
mitotic nuclear membrane disassembly
homologous chromosome pairing at meiosis
Spermatogeneza
protein transport
regulation of cellular response to heat
GO:0022415 viral process
mRNA export from nucleus
GO:0046795 intracellular transport of virus
tRNA export from nucleus
spindle pole body duplication
GO:1905616 regulation of gene silencing by miRNA
regulation of glycolytic process
GO:0015915 transport
nuclear pore organization
Izvori:Amigo / QuickGO
Ortolozi
VrsteČovjekMiš
Entrez
Ensembl
UniProt
RefSeq (mRNK)

NM_001168551
NM_018087

NM_028355

RefSeq (bjelančevina)

NP_001162023
NP_060557

NP_082631

Lokacija (UCSC)Chr 1: 53.77 – 53.84 MbChr 4: 107.22 – 107.27 Mb
PubMed pretraga[3][4]
Wikipodaci
Pogledaj/uredi – čovjekPogledaj/uredi – miš

Aminokiselinska sekvenca

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Dužina polipeptidnog lanca je 674 aminokiseline, a molekulska težina 76.305 Da.[8].

1020304050
MATAVSRPCAGRSRDILWRVLGWRIVASIVWSVLFLPICTTVFIIFSRID
LFHPIQWLSDSFSDLYSSYVIFYFLLLSVVIIIISIFNVEFYAVVPSIPC
SRLALIGKIIHPQQLMHSFIHAAMGMVMAWCAAVITQGQYSFLVVPCTGT
NSFGSPAAQTCLNEYHLFFLLTGAFMGYSYSLLYFVNNMNYLPFPIIQQY
KFLRFRRSLLLLVKHSCVESLFLVRNFCILYYFLGYIPKAWISTAMNLHI
DEQVHRPLDTVSGLLNLSLLYHVWLCGVFLLTTWYVSWILFKIYATEAHV
FPVQPPFAEGSDECLPKVLNSNPPPIIKYLALQDLMLLSQYSPSRRQEVF
SLSQPGGHPHNWTAISRECLNLLNGMTQKLILYQEAAATNGRVSSSYPVE
PKKLNSPEETAFQTPKSSQMPRPSVPPLVKTSLFSSKLSTPDVVSPFGTP
FGSSVMNRMAGIFDVNTCYGSPQSPQLIRRGPRLWTSASDQQMTEFSNPS
PSTSISAEGKTMRQPSVIYSWIQNKREQIKNFLSKRVLIMYFFSKHPEAS
IQAVFSDAQMHIWALEGLSHLVAASFTEDRFGVVQTTLPAILNTLLTLQE
AVDKYFKLPHASSKPPRISGSLVDTSYKTLRFAFRASLKTAIYRITTTFG
EHLNAVQASAEHQKRLQQFLEFKE

Funkcija

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Nukleoporin NDC1 sidri aladin za kompleks jedarnih pora.[9]

Reference

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000058804 - Ensembl, maj 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000028614 - Ensembl, maj 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Lau CK, Delmar VA, Forbes DJ (Aug 2006). "Topology of yeast Ndc1p: predictions for the human NDC1/NET3 homologue". Anat Rec A. 288 (7): 681–94. doi:10.1002/ar.a.20335. PMC 3049984. PMID 16779818.
  6. ^ Schirmer EC, Florens L, Guan T, Yates JR 3rd, Gerace L (Sep 2003). "Nuclear membrane proteins with potential disease links found by subtractive proteomics". Science. 301 (5638): 1380–2. Bibcode:2003Sci...301.1380S. doi:10.1126/science.1088176. PMID 12958361. S2CID 23832536.
  7. ^ "Entrez Gene: TMEM48 transmembrane protein 48".
  8. ^ "UniProt, Q9BTX1" (jezik: англ.). Pristupljeno 28 серпня 2017. Provjerite vrijednost datuma u parametru: |access-date= (pomoć)CS1 održavanje: nepoznati jezik (link)
  9. ^ Kind, Barbara; Koehler, Katrin; Lorenz, Mike; Huebner, Angela (decembar 2009). "The nuclear pore complex protein ALADIN is anchored via NDC1 but not via POM121 and GP210 in the nuclear envelope". Biochemical and Biophysical Research Communications. 390 (2): 205–210. doi:10.1016/j.bbrc.2009.09.080. PMID 19782045.

Dopunska literatura

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