Proteinski misato homolog 1 jest protein koji je kod ljudi kodiran genom MSTO1 sa hromosoma 1.[5][6]

MSTO1
Identifikatori
AliasiMSTO1
Vanjski ID-jeviOMIM: 617619 MGI: 2385175 HomoloGene: 41228 GeneCards: MSTO1
Lokacija gena (čovjek)
Hromosom 1 (čovjek)
Hrom.Hromosom 1 (čovjek)[1]
Hromosom 1 (čovjek)
Genomska lokacija za MSTO1
Genomska lokacija za MSTO1
Bend1q22Početak155,610,205 bp[1]
Kraj155,614,951 bp[1]
Lokacija gena (miš)
Hromosom 3 (miš)
Hrom.Hromosom 3 (miš)[2]
Hromosom 3 (miš)
Genomska lokacija za MSTO1
Genomska lokacija za MSTO1
Bend3|3 F1Početak88,812,414 bp[2]
Kraj88,821,306 bp[2]
Ontologija gena
Molekularna funkcija molekularna funkcija
Ćelijska komponenta mitochondrial outer membrane
mitohondrija
membrana
citoplazma
Biološki proces mitochondrion organization
mitochondrion distribution
mitochondrial genome maintenance
mitotic sister chromatid segregation
mitotic spindle assembly
Izvori:Amigo / QuickGO
Ortolozi
VrsteČovjekMiš
Entrez
Ensembl
UniProt
RefSeq (mRNK)
NM_001256532
NM_001256533
NM_018116
NM_001350772
NM_001350773

NM_001350774
NM_001350775
NM_001350776
NM_001350777
NM_001350778
NM_001350779
NM_001350780
NM_001350781
NM_001350782
NM_001350783
NM_001350784
NM_001350785
NM_001350786
NM_001350787
NM_001350788
NM_001350789

NM_144898

RefSeq (bjelančevina)
NP_001243461
NP_001243462
NP_060586
NP_001337701
NP_001337702

NP_001337703
NP_001337704
NP_001337705
NP_001337706
NP_001337707
NP_001337708
NP_001337709
NP_001337710
NP_001337711
NP_001337712
NP_001337713
NP_001337714
NP_001337715
NP_001337716
NP_001337717
NP_001337718

NP_659147

Lokacija (UCSC)Chr 1: 155.61 – 155.61 MbChr 3: 88.81 – 88.82 Mb
PubMed pretraga[3][4]
Wikipodaci
Pogledaj/uredi – čovjekPogledaj/uredi – miš

Aminokiselinska sekvenca

uredi

Dužina polipeptidnog lanca je 570 aminokiselina, a molekulska težina 61.835 Da.[7]

1020304050
MAGGAREVLTLQLGHFAGFVGAHWWNQQDAALGRATDSKEPPGELCPDVL
YRTGRTLHGQETYTPRLILMDLKGSLSSLKEEGGLYRDKQLDAAIAWQGK
LTTHKEELYPKNPYLQDFLSAEGVLSSDGVWRVKSIPNGKGSSPLPTATT
PKPLIPTEASIRVWSDFLRVHLHPRSICMIQKYNHDGEAGRLEAFGQGES
VLKEPKYQEELEDRLHFYVEECDYLQGFQILCDLHDGFSGVGAKAAELLQ
DEYSGRGIITWGLLPGPYHRGEAQRNIYRLLNTAFGLVHLTAHSSLVCPL
SLGGSLGLRPEPPVSFPYLHYDATLPFHCSAILATALDTVTVPYRLCSSP
VSMVHLADMLSFCGKKVVTAGAIIPFPLAPGQSLPDSLMQFGGATPWTPL
SACGEPSGTRCFAQSVVLRGIDRACHTSQLTPGTPPPSALHACTTGEEIL
AQYLQQQQPGVMSSSHLLLTPCRVAPPYPHLFSSCSPPGMVLDGSPKGAA
VESIPVFGALCSSSSLHQTLEALARDLTKLDLRRWASFMDAGVEHDDVAE
LLQELQSLAQCYQGGDSLVD

Struktura

uredi

MSTO1 gen ima 5134 para baza (lociranih u hromosomu 1), a MSTO1 protein je dug 570 aminokiselina. Nalazi se u vanjskoj membrani mitohondrija i uključen je u regulaciju mitohondrijske distribucije i morfologije.[8]

Protein misato sadrži N-terminalni miozinski domen sličan misato segmentu II i centralni domen tubulina.[8]

Reference

uredi
  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000125459 - Ensembl, maj 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000068922 - Ensembl, maj 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Kuryshev VY, Vorobyov E, Zink D, Schmitz J, Rozhdestvensky TS, Munstermann E, Ernst U, Wellenreuther R, Moosmayer P, Bechtel S, Schupp I, Horst J, Korn B, Poustka A, Wiemann S (Jul 2006). "An anthropoid-specific segmental duplication on human chromosome 1q22". Genomics. 88 (2): 143–51. doi:10.1016/j.ygeno.2006.02.002. PMID 16545939.
  6. ^ "Entrez Gene: MSTO1 misato homolog 1 (Drosophila)".
  7. ^ "UniProt, Q9BUK6" (jezik: engleski). Pristupljeno 14. 12. 2021.
  8. ^ a b Kimura M, Okano Y (april 2007). "Human Misato regulates mitochondrial distribution and morphology". Exp. Cell Res. 313 (7): 1393–404. doi:10.1016/j.yexcr.2007.02.004. PMID 17349998.

Dopunska literatura

uredi