MPC2
Mitohondrijski piruvatni nosač 2 (MPC2), znan i kao moždani protein 44 (BRP44), jest protein koji je kod ljudi kodiran genom MPC2 sa hromosoma 1.[5][6][7]
Aminokiselinska sekvenca
urediDužina polipeptidnog lanca je 127 aminokiselina, a molekulska težina 14.279 Da.[8]
| 10 | 20 | 30 | 40 | 50 | ||||
|---|---|---|---|---|---|---|---|---|
| MSAAGARGLR | ATYHRLLDKV | ELMLPEKLRP | LYNHPAGPRT | VFFWAPIMKW | ||||
| GLVCAGLADM | ARPAEKLSTA | QSAVLMATGF | IWSRYSLVII | PKNWSLFAVN | ||||
| FFVGAAGASQ | LFRIWRYNQE | LKAKAHK |
Funkcija
urediMPC2 dio je porodice proteina mitohondrikski nosači pirivata (MPC) [9] Ovaj protein uključen je u transport piruvata kroz unutrašnju mitohondrijsku membranu, u pripremi za reakciju piruvat-dehidrogenaze.[10]
Interaktivna mapa puta
urediReference
uredi- ^ a b c GRCh38: Ensembl release 89: ENSG00000143158 - Ensembl, maj 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000026568 - Ensembl, maj 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Wiemann S, Weil B, Wellenreuther R, Gassenhuber J, Glassl S, Ansorge W, Böcher M, Blöcker H, Bauersachs S, Blum H, Lauber J, Düsterhöft A, Beyer A, Köhrer K, Strack N, Mewes HW, Ottenwälder B, Obermaier B, Tampe J, Heubner D, Wambutt R, Korn B, Klein M, Poustka A (Mar 2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
- ^ Tsou AP, Lai C, Danielson P, Noonan DJ, Sutcliffe JG (Dec 1986). "Structural characterization of a heterogeneous family of rat brain mRNAs". Mol Cell Biol. 6 (3): 768–78. doi:10.1128/mcb.6.3.768. PMC 367577. PMID 3022128.
- ^ "Entrez Gene: BRP44 brain protein 44".
- ^ "UniProt, O95563" (jezik: engleski). Pristupljeno 13. 12. 2021.
- ^ https://www.uniprot.org/uniprot/?query=family:%22mitochondrial+pyruvate+carrier+%28MPC%29+%28TC+2.A.105%29+family%22
- ^ https://www.ebi.ac.uk/QuickGO/term/GO:0050833
Dopunska literatura
uredi- Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
- Simpson JC, Wellenreuther R, Poustka A, Pepperkok R, Wiemann S (2001). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing". EMBO Rep. 1 (3): 287–92. doi:10.1093/embo-reports/kvd058. PMC 1083732. PMID 11256614.
- Wiemann S, Arlt D, Huber W, Wellenreuther R, Schleeger S, Mehrle A, Bechtel S, Sauermann M, Korf U, Pepperkok R, Sültmann H, Poustka A (2004). "From ORFeome to biology: a functional genomics pipeline". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
- Mehrle A, Rosenfelder H, Schupp I, del Val C, Arlt D, Hahne F, Bechtel S, Simpson J, Hofmann O, Hide W, Glatting KH, Huber W, Pepperkok R, Poustka A, Wiemann S (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.