Aminokiselinska sekvenca
uredi
Dužina polipeptidnog lanca je 458 aminokiselina , а molekulska težina 50.429 Da .[ 2]
10 20 30 40 50 MELEKREKRS LLNKNLEEKL TVSAGGSEAK PLIFTFVPTV RRLPTHTQLA DTSKFLVKIP EESSDKSPET VNRSKSNDYL TLNAGSQQER DQAKLTCPSE VSGTILQERE FEANKLQGMQ QSDLFKAEYV LIVDSEGEDE AASRKVEQGP PGGIGTAAVR PKSLAISSSL VSDVVRPKTQ GTDLKTSSHP EMLHGMAPQQ KHGQQYKTKS SYKAFAAIPT NTLLLEQKAL DEPAKTESVS KDNTLEPPVE LYFPAQLRQQ TEELCATIDK VLQDSLSMHS SDSPSRSPKT LLGSDTVKTP TTLPRAAGRE TKYANLSSPS STVSESQLTK PGVIRPVPVK SRILLKKEEE VYEPNPFSKY LEDNSDLFSE QDVTVPPKPV SLHPLYQTKL YPPAKSLLHP QTLSHADCLA PGPFSHLSFS LSDEQENSHT LLSHNACNKL SHPMVAIPEH EALDSKEQ
Ekspresija i interakcije
uredi
Funkcija MLIP -a nije poznata, ali se pretpostavlja da može imati ulogu u rastu srca i srčanih oboljenja. Postoje neki dokazi da MLIP može biti uključen u održavanje srčane homeostaze i u početnu reakciju na promjene u radnom opterećenju. Međutim, model nokaut-miševa imao je normalnu srčanu funkciju i bez strukturnih abnormalnosti, što pokazuje da MLIP nije od vitalnog značaja za ove procese.[ 3]
^ a b c "Entrez Gene: C6orf142 chromosome 6 open reading frame 142" .^ "UniProt, Q5VWP3" (jezik: engleski). Pristupljeno 3. 10. 2021 .^ a b c Cattin ME, Wang J, Weldrick JJ, Roeske CL, Mak E, Thorn SL, DaSilva JN, Wang Y, Lusis AJ, Burgon PG (oktobar 2015). "Deletion of MLIP (muscle-enriched A-type lamin-interacting protein) leads to cardiac hyperactivation of Akt/mammalian target of rapamycin (mTOR) and impaired cardiac adaptation" . The Journal of Biological Chemistry . 290 (44): 26699–714. doi :10.1074/jbc.M115.678433 . PMC 4646324 PMID 26359501 . ^ "MLIP Gene (Protein Coding)" . Genecards.org . GeneCards, Human gene database. Pristupljeno 10. 11. 2016 .^ Šablon:Ensembl ^ a b Ahmady E, Deeke SA, Rabaa S, Kouri L, Kenney L, Stewart AF, Burgon PG (juni 2011). "Identification of a novel muscle A-type lamin-interacting protein (MLIP)" . The Journal of Biological Chemistry . 286 (22): 19702–13. doi :10.1074/jbc.M110.165548 . PMC 3103349 PMID 21498514 .
Dopunska literatura
uredi
Slachta CA, Jeevanandam V, Goldman B, Lin WL, Platsoucas CD (septembar 2000). "Coronary arteries from human cardiac allografts with chronic rejection contain oligoclonal T cells: persistence of identical clonally expanded TCR transcripts from the early post-transplantation period (endomyocardial biopsies) to chronic rejection (coronary arteries)" . Journal of Immunology . 165 (6): 3469–83. doi :10.4049/jimmunol.165.6.3469 PMID 10975868 . Costello PJ, Winchester RJ, Curran SA, Peterson KS, Kane DJ, Bresnihan B, FitzGerald OM (februar 2001). "Psoriatic arthritis joint fluids are characterized by CD8 and CD4 T cell clonal expansions appear antigen driven" . Journal of Immunology . 166 (4): 2878–86. doi :10.4049/jimmunol.166.4.2878 PMID 11160357 . Zemlin M, Bauer K, Hummel M, Pfeiffer S, Devers S, Zemlin C, Stein H, Versmold HT (mart 2001). "The diversity of rearranged immunoglobulin heavy chain variable region genes in peripheral blood B cells of preterm infants is restricted by short third complementarity-determining regions but not by limited gene segment usage" . Blood . 97 (5): 1511–3. doi :10.1182/blood.V97.5.1511 PMID 11222402 . Harfst E, Cooper S, Neubauer S, Distel L, Grawunder U (oktobar 2000). "Normal V(D)J recombination in cells from patients with Nijmegen breakage syndrome". Molecular Immunology . 37 (15): 915–29. doi :10.1016/S0161-5890(01)00008-6 . PMID 11282395 . Willenbrock K, Ichinohasama R, Kadin ME, Miura I, Terui T, Meguro K, Fukuhara O, DeCoteau JF, Hansmann ML (septembar 2002). "T-cell variant of classical Hodgkin's lymphoma with nodal and cutaneous manifestations demonstrated by single-cell polymerase chain reaction" . Laboratory Investigation; A Journal of Technical Methods and Pathology . 82 (9): 1103–9. doi :10.1097/01.lab.0000027839.98023.5a PMID 12218070 . S2CID 23591559 . Kimura K, Wakamatsu A, Suzuki Y, Ota T, Nishikawa T, Yamashita R, Yamamoto J, Sekine M, Tsuritani K, Wakaguri H, Ishii S, Sugiyama T, Saito K, Isono Y, Irie R, Kushida N, Yoneyama T, Otsuka R, Kanda K, Yokoi T, Kondo H, Wagatsuma M, Murakawa K, Ishida S, Ishibashi T, Takahashi-Fujii A, Tanase T, Nagai K, Kikuchi H, Nakai K, Isogai T, Sugano S (januar 2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes" . Genome Research . 16 (1): 55–65. doi :10.1101/gr.4039406 . PMC 1356129 PMID 16344560 .
