Glavi modulator sa natporodičnim domenom 7 jest protein koji je kod ljudi kodiran genom MFSD7 sa hromosoma 4.[5]

MFSD7
Identifikatori
AliasiSLC49A3
Vanjski ID-jeviMGI: 2442629 HomoloGene: 49990 GeneCards: SLC49A3
Lokacija gena (čovjek)
Hromosom 4 (čovjek)
Hrom.Hromosom 4 (čovjek)[1]
Hromosom 4 (čovjek)
Genomska lokacija za MFSD7
Genomska lokacija za MFSD7
Bend4p16.3Početak681,829 bp[1]
Kraj689,441 bp[1]
Lokacija gena (miš)
Hromosom 5 (miš)
Hrom.Hromosom 5 (miš)[2]
Hromosom 5 (miš)
Genomska lokacija za MFSD7
Genomska lokacija za MFSD7
Bend5|5 FPočetak108,588,920 bp[2]
Kraj108,596,966 bp[2]
Ortolozi
VrsteČovjekMiš
Entrez
Ensembl
UniProt
RefSeq (mRNK)

NM_001294341
NM_001294342
NM_032219

NM_172883
NM_001359977

RefSeq (bjelančevina)
NP_001281270
NP_001281271
NP_115595
NP_001364988
NP_001364989

NP_001364990
NP_001364991

NP_766471
NP_001346906

Lokacija (UCSC)Chr 4: 0.68 – 0.69 MbChr 5: 108.59 – 108.6 Mb
PubMed pretraga[3][4]
Wikipodaci
Pogledaj/uredi – čovjekPogledaj/uredi – miš

Aminokiselinska sekvenca

uredi

Dužina polipeptidnog lanca je 560 aminokiselina, a molekulska težina Da. 58 427[6]

1020304050
MAGPTEAETGLAEPRALCAQRGHRTYARRWVFLLAISLLNCSNATLWLSF
APVADVIAEDLVLSMEQINWLSLVYLVVSTPFGVAAIWILDSVGLRAATI
LGAWLNFAGSVLRMVPCMVVGTQNPFAFLMGGQSLCALAQSLVIFSPAKL
AALWFPEHQRATANMLATMSNPLGVLVANVLSPVLVKKGEDIPLMLGVYT
IPAGVVCLLSTICLWESVPPTPPSAGAASSTSEKFLDGLKLQLMWNKAYV
ILAVCLGGMIGISASFSALLEQILCASGHSSGFSGLCGALFITFGILGAL
ALGPYVDRTKHFTEATKIGLCLFSLACVPFALVSQLQGQTLALAATCSLL
GLFGFSVGPVAMELAVECSFPVGEGAATGMIFVLGQAEGILIMLAMTALT
VRRSEPSLSTCQQGEDPLDWTVSLLLMAGLCTFFSCILAVFFHTPYRRLQ
AESGEPPSTRNAVGGADSGPGVDRGGAGRAGVLGPSTATPECTARGASLE
DPRGPGSPHPACHRATPRAQGPAATDAPSRPGRLAGRVQASRFIDPAGSH
SSFSSPWVIT

Funkcija

uredi

MFSD7 je atipski protein porodice SLC,[7][8] dakle predviđeni transporter SLC-proteina . Filogenetski se grupira u porodicu atipskih MFS transportera 5 i porodicu SLC49.

Reference

uredi
  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000169026 - Ensembl, maj 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000029490 - Ensembl, maj 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: Major facilitator superfamily domain containing 7".
  6. ^ "UniProt, Q6UXD7" (jezik: engleski). Pristupljeno 29. 10. 2021.
  7. ^ Perland E, Bagchi S, Klaesson A, Fredriksson R (septembar 2017). "Characteristics of 29 novel atypical solute carriers of major facilitator superfamily type: evolutionary conservation, predicted structure and neuronal co-expression". Open Biology. 7 (9): 170142. doi:10.1098/rsob.170142. PMC 5627054. PMID 28878041.
  8. ^ Perland E, Fredriksson R (mart 2017). "Classification Systems of Secondary Active Transporters". Trends in Pharmacological Sciences. 38 (3): 305–315. doi:10.1016/j.tips.2016.11.008. PMID 27939446.