Protein MAP kinaza aktivirajućeg domena ćelijske smrti je enzim koji je kod ljudi kodiran genom MADD.[5][6][7]

MADD
Identifikatori
AliasiMADD
Vanjski ID-jeviOMIM: 603584 MGI: 2444672 HomoloGene: 14249 GeneCards: MADD
Lokacija gena (čovjek)
Hromosom 11 (čovjek)
Hrom.Hromosom 11 (čovjek)[1]
Hromosom 11 (čovjek)
Genomska lokacija za MADD
Genomska lokacija za MADD
Bend11p11.2Početak47,269,161 bp[1]
Kraj47,330,031 bp[1]
Lokacija gena (miš)
Hromosom 2 (miš)
Hrom.Hromosom 2 (miš)[2]
Hromosom 2 (miš)
Genomska lokacija za MADD
Genomska lokacija za MADD
Bend2|2 E1Početak91,137,360 bp[2]
Kraj91,183,837 bp[2]
Obrazac RNK ekspresije


Više referentnih podataka o ekspresiji
Ontologija gena
Molekularna funkcija death receptor binding
guanyl-nucleotide exchange factor activity
protein kinase activator activity
GO:0001948, GO:0016582 vezivanje za proteine
Ćelijska komponenta integral component of membrane
membrana
ćelijska membrana
citoplazma
citosol
Biološki proces regulation of apoptotic process
regulation of extrinsic apoptotic signaling pathway
execution phase of apoptosis
regulation of tumor necrosis factor-mediated signaling pathway
regulation of Rab protein signal transduction
regulation of cell cycle
cell surface receptor signaling pathway
regulation of extrinsic apoptotic signaling pathway via death domain receptors
GO:0097285 apoptoza
Izvori:Amigo / QuickGO
Ortolozi
VrsteČovjekMiš
Entrez
Ensembl
UniProt
RefSeq (mRNK)
NM_001135943
NM_001135944
NM_003682
NM_130470
NM_130471

NM_130472
NM_130473
NM_130474
NM_130475
NM_130476

NM_001177719
NM_001177720
NM_001177721
NM_001177722
NM_001177723

NM_001177724
NM_001177725
NM_001177726
NM_001177727
NM_001177728
NM_001177729
NM_145527

RefSeq (bjelančevina)
NP_001129415
NP_001129416
NP_003673
NP_569826
NP_569827

NP_569828
NP_569829
NP_569830
NP_569831
NP_569832
NP_001363500
NP_001363501
NP_001363502
NP_001363503
NP_001363504
NP_001363505
NP_001363506
NP_001363507
NP_001363508
NP_001363509
NP_001363510
NP_001363511
NP_001363512
NP_001363513
NP_001363514
NP_001363515
NP_001363522
NP_001363523
NP_001363524
NP_001363525
NP_001363526
NP_001363527
NP_001363528
NP_001363529
NP_001363530
NP_001363531
NP_001363532
NP_001363533
NP_001363534
NP_001363535
NP_001363536
NP_001363537
NP_001363538
NP_001363539
NP_001363540
NP_001363541
NP_001363542
NP_001363543
NP_001363544
NP_001363545
NP_001363546
NP_001363547
NP_001363548
NP_001363549
NP_001363550
NP_001363551
NP_001363552
NP_001363553
NP_001363554
NP_001363555
NP_001363556
NP_001363557
NP_001363558
NP_001363559
NP_001363560
NP_001363561
NP_001363562
NP_001363563
NP_001363564
NP_001363565
NP_001363566
NP_001363567
NP_001363568
NP_001363569
NP_001363570
NP_001363571
NP_001363572
NP_001363573
NP_001363574
NP_001363575
NP_001363576
NP_001363577
NP_001363578
NP_001363579
NP_001363580
NP_001363581
NP_001363582
NP_001363583
NP_001363584
NP_001363585
NP_001363586
NP_001363587
NP_001363588
NP_001363589
NP_001363590
NP_001363591
NP_001363592

NP_001171190
NP_001171191
NP_663502

Lokacija (UCSC)Chr 11: 47.27 – 47.33 MbChr 2: 91.14 – 91.18 Mb
PubMed pretraga[3][4]
Wikipodaci
Pogledaj/uredi – čovjekPogledaj/uredi – miš

Faktor tumorske nekroze alfa (TNF-alfa) je signalna molekul kojA stupa u interakciju s jednim od dva receptora na ciljanim ćelijama za apoptozu. ApoptotSki signal se transducira unutar ovih ćelija pomoću citoplazmatskih proteinSKIH adaptera. Protein kodiran ovim genom je adapterski protein koji sadrži domen smrti i koji stupa u interakciju s domenom smrti TNF-alfa receptora 1, kako bi aktivirao mitogen-aktiviranu protein-kinazu (MAPK) i proširio apoptotski signal. Vezan je za membranu i eksprimiran je na većem nivou u neoplazijskim ćelijama nego u normalnim ćelijama. Za ovaj gen opisano je nekoliko varijanti transkripta koje kodiraju različite izoforme.[7]

Aminokiselinska sekvenca uredi

Dužina polipeptidnog lanca je 1647 aminokiselina, a molekulska težina 183.303 Da.[8]

1020304050
MVQKKKFCPRLLDYLVIVGARHPSSDSVAQTPELLRRYPLEDHTEFPLPP
DVVFFCQPEGCLSVRQRRMSLRDDTSFVFTLTDKDTGVTRYGICVNFYRS
FQKRISKEKGEGGAGSRGKEGTHATCASEEGGTESSESGSSLQPLSADST
PDVNQSPRGKRRAKAGSRSRNSTLTSLCVLSHYPFFSTFRECLYTLKRLV
DCCSERLLGKKLGIPRGVQRDTMWRIFTGSLLVEEKSSALLHDLREIEAW
IYRLLRSPVPVSGQKRVDIEVLPQELQPALTFALPDPSRFTLVDFPLHLP
LELLGVDACLQVLTCILLEHKVVLQSRDYNALSMSVMAFVAMIYPLEYMF
PVIPLLPTCMASAEQLLLAPTPYIIGVPASFFLYKLDFKMPDDVWLVDLD
SNRVIAPTNAEVLPILPEPESLELKKHLKQALASMSLNTQPILNLEKFHE
GQEIPLLLGRPSNDLQSTPSTEFNPLIYGNDVDSVDVATRVAMVRFFNSA
NVLQGFQMHTRTLRLFPRPVVAFQAGSFLASRPRQTPFAEKLARTQAVEY
FGEWILNPTNYAFQRIHNNMFDPALIGDKPKWYAHQLQPIHYRVYDSNSQ
LAEALSVPPERDSDSEPTDDSGSDSMDYDDSSSSYSSLGDFVSEMMKCDI
NGDTPNVDPLTHAALGDASEVEIDELQNQKEAEEPGPDSENSQENPPLRS
SSSTTASSSPSTVIHGANSEPADSTEMDDKAAVGVSKPLPSVPPSIGKSN
VDRRQAEIGEGSVRRRIYDNPYFEPQYGFPPEEDEDEQGESYTPRFSQHV
SGNRAQKLLRPNSLRLASDSDAESDSRASSPNSTVSNTSTEGFGGIMSFA
SSLYRNHSTSFSLSNLTLPTKGAREKATPFPSLKVFGLNTLMEIVTEAGP
GSGEGNRRALVDQKSSVIKHSPTVKREPPSPQGRSSNSSENQQFLKEVVH
SVLDGQGVGWLNMKKVRRLLESEQLRVFVLSKLNRMVQSEDDARQDIIPD
VEISRKVYKGMLDLLKCTVLSLEQSYAHAGLGGMASIFGLLEIAQTHYYS
KEPDKRKRSPTESVNTPVGKDPGLAGRGDPKAMAQLRVPQLGPRAPSATG
KGPKELDTRSLKEENFIASIELWNKHQEVKKQKALEKQRPEVIKPVFDLG
ETEEKKSQISADSGVSLTSSSQRTDQDSVIGVSPAVMIRSSSQDSEVSTV
VSNSSGETLGADSDLSSNAGDGPGGEGSVHLASSRGTLSDSEIETNSATS
TIFGKAHSLKPSIKEKLAGSPIRTSEDVSQRVYLYEGLLGRDKGSMWDQL
EDAAMETFSISKERSTLWDQMQFWEDAFLDAVMLEREGMGMDQGPQEMID
RYLSLGEHDRKRLEDDEDRLLATLLHNLISYMLLMKVNKNDIRKKVRRLM
GKSHIGLVYSQQINEVLDQLANLNGRDLSIWSSGSRHMKKQTFVVHAGTD
TNGDIFFMEVCDDCVVLRSNIGTVYERWWYEKLINMTYCPKTKVLCLWRR
NGSETQLNKFYTKKCRELYYCVKDSMERAAARQQSIKPGPELGGEFPVQD
LKTGEGGLLQVTLEGINLKFMHNQVFIELNHIKKCNTVRGVFVLEEFVPE
IKEVVSHKYKTPMAHEICYSVLCLFSYVAAVHSSEEDLRTPPRPVSS

Reference uredi

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000110514 - Ensembl, maj 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000040687 - Ensembl, maj 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Schievella AR, Chen JH, Graham JR, Lin LL (Jun 1997). "MADD, a novel death domain protein that interacts with the type 1 tumor necrosis factor receptor and activates mitogen-activated protein kinase". J Biol Chem. 272 (18): 12069–75. doi:10.1074/jbc.272.18.12069. PMID 9115275.
  6. ^ Chow VT, Lim KM, Lim D (Nov 1998). "The human DENN gene: genomic organization, alternative splicing, and localization to chromosome 11p11.21-p11.22". Genome. 41 (4): 543–52. doi:10.1139/gen-41-4-543. PMID 9796103.
  7. ^ a b "Entrez Gene: MADD MAP-kinase activating death domain".
  8. ^ "UniProt, Q8WXG6". Pristupljeno 24. 8. 2021.

Dopunska literatura uredi

Vanjski linkovi uredi