LUC7L2

LUC7L2
Identifikatori
Aliasi	LUC7L2
Vanjski ID-jevi	OMIM: 613056 MGI: 2183260 HomoloGene: 56737 GeneCards: LUC7L2
Lokacija gena (čovjek)
Hrom.	Hromosom 7 (čovjek)
Kraj	139,423,457 bp
Lokacija gena (miš)
Hrom.	Hromosom 6 (miš)
Kraj	38,609,470 bp
Obrazac RNK ekspresije
	; ;
	Više referentnih podataka o ekspresiji
Ontologija gena
Molekularna funkcija	• vezivanje enzima; • GO:0001948, GO:0016582 vezivanje za proteine; • mRNA binding; • vezivanje sa RNK;
Ćelijska komponenta	• U1 snRNP; • nuclear speck; • U2-type prespliceosome; • jedro; • nukleoplazma;
Biološki proces	• mRNA splice site selection;
	Izvori:Amigo / QuickGO
Ortolozi
	51631
	192196
	ENSG00000146963
	ENSMUSG00000029823
	Q9Y383
	Q7TNC4
	NM_016019; NM_001244585; NM_001270643
NM_001170848; NM_001170849; NM_138680; NM_001311099; NM_001311100;
	NM_001331222; NM_001331223
	NP_001231514; NP_001257572; NP_057103
NP_001164319; NP_001164320; NP_001298028; NP_001298029; NP_001318151;
	NP_001318152; NP_619621
	Wikipodaci
Pogledaj/uredi – čovjek	Pogledaj/uredi – miš

Pretpostavljeni RNK-vezujući protein sličan Luc7 2 je protein koji je kod ljudi kodiran genom LUC7L2.^[5]^[6]

U nedavnoj (2021.) studiji navodi se da su ksidativna fosforilacija (OXPHOS) i glikoliza dva glavna puta za proizvodnju ATP-a. Oslanjanje na svako varira u zavisnosti od tkiva i stanja ćelija i može uticati na osjetljivost na bolesti. Još je nepoznat cijeli skup molekulskih mehanizama koji upravljaju relativnom ekspresijom i ravnotežom ova dva puta. Fokusirali su se na gene čiji gubitak dovodi do povećanja aktivnosti OXPHOS-a. Neočekivano, ova klasa gena je obogaćena za komponente mehanizama za preradu pre-iRNK, posebno za podjedinice U1 snRNP. Među njima, pokazano je da LUC7L2 potiskuje OXPHOS i podstiče glikolizu putem više mehanizama, uključujući (1) preradu glkoliznog enzima PFKM, radi suzbijanja sinteze glikogena, (2) prerada antiportera cistin/glutamat SLC7A11 (xCT) za suzbijanje oksidacije glutamata, i (3) sekundarna represija formiranja mitohondrijskog respiratornog superkompleksa. Dobijeni rezultati povezuju ekspresiju LUC7L2 i općenito, U1 snRNP s ćelijskim metabolizmom energije.^[7]

Aminokiselinska sekvenca

Dužina polipeptidnog lanca je 392 aminokiseline, а molekulska težina 46.514 Da.^[8]

10	20	30	40	50
MSAQAQMRAM	LDQLMGTSRD	GDTTRQRIKF	SDDRVCKSHL	LNCCPHDVLS
GTRMDLGECL	KVHDLALRAD	YEIASKEQDF	FFELDAMDHL	QSFIADCDRR
TEVAKKRLAE	TQEEISAEVA	AKAERVHELN	EEIGKLLAKV	EQLGAEGNVE
ESQKVMDEVE	KARAKKREAE	EVYRNSMPAS	SFQQQKLRVC	EVCSAYLGLH
DNDRRLADHF	GGKLHLGFIE	IREKLEELKR	VVAEKQEKRN	QERLKRREER
EREEREKLRR	SRSHSKNPKR	SRSREHRRHR	SRSMSRERKR	RTRSKSREKR
HRHRSRSSSR	SRSRSHQRSR	HSSRDRSRER	SKRRSSKERF	RDQDLASCDR
DRSSRDRSPR	DRDRKDKKRS	YESANGRSED	RRSSEEREAG	EI

C: Cistein
D: Aspartat
E: Glutamat
F: Fenilalanin
G: Glicin
H: Histidin
I: Izoleucin
K: Lizin
L: Leucin
M: Metionin
N: Asparagin
P: Prolin
Q: Glutamin
R: Arginin
S: Serin
T: Treonin
V: Valin
W:Triptofan
Y: Tirozin

Reference

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000146963 - Ensembl, maj 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000029823 - Ensembl, maj 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Lai CH, Chou CY, Ch'ang LY, Liu CS, Lin W (Aug 2000). "Identification of Novel Human Genes Evolutionarily Conserved in Caenorhabditis elegans by Comparative Proteomics". Genome Res. 10 (5): 703–13. doi:10.1101/gr.10.5.703. PMC 310876. PMID 10810093.
^ "Entrez Gene: LUC7L2 LUC7-like 2 (S. cerevisiae)".
^ Alexis A Jourdain, Bridget E Begg, Eran Mick, Hardik Shah, Sarah E Calvo, Owen S Skinner, Rohit Sharma , Steven M Blue, Gene W Yeo, Christopher B Burge, Vamsi K Mootha (2021): Loss of LUC7L2 and U1 snRNP subunits shifts energy metabolism from glycolysis to OXPHOS. Mol Cell, 81(9):1905-1919.e12; pmid: 33852893; pmcid: pmc8314041 (available on 2022-05-06); doi: 10.1016/j.molcel.2021.02.033
^ "UniProt, Q9Y383" (jezik: engleski). Pristupljeno 26. 9. 2021.

Dopunska literatura

Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Hillier LW, Fulton RS, Fulton LA, et al. (2003). "The DNA sequence of human chromosome 7". Nature. 424 (6945): 157–64. doi:10.1038/nature01782. PMID 12853948.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Colland F, Jacq X, Trouplin V, et al. (2004). "Functional Proteomics Mapping of a Human Signaling Pathway". Genome Res. 14 (7): 1324–32. doi:10.1101/gr.2334104. PMC 442148. PMID 15231748.
Jin J, Smith FD, Stark C, et al. (2004). "Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization". Curr. Biol. 14 (16): 1436–50. doi:10.1016/j.cub.2004.07.051. PMID 15324660. S2CID 2371325.
Goehler H, Lalowski M, Stelzl U, et al. (2004). "A protein interaction network links GIT1, an enhancer of huntingtin aggregation, to Huntington's disease". Mol. Cell. 15 (6): 853–65. doi:10.1016/j.molcel.2004.09.016. PMID 15383276.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Andersen JS, Lam YW, Leung AK, et al. (2005). "Nucleolar proteome dynamics". Nature. 433 (7021): 77–83. doi:10.1038/nature03207. PMID 15635413. S2CID 4344740.
Stelzl U, Worm U, Lalowski M, et al. (2005). "A human protein-protein interaction network: a resource for annotating the proteome". Cell. 122 (6): 957–68. doi:10.1016/j.cell.2005.08.029. hdl:11858/00-001M-0000-0010-8592-0. PMID 16169070. S2CID 8235923.
Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.
Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein–protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000146963 - Ensembl, maj 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000029823 - Ensembl, maj 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10810093-5] Lai CH, Chou CY, Ch'ang LY, Liu CS, Lin W (Aug 2000). "Identification of Novel Human Genes Evolutionarily Conserved in Caenorhabditis elegans by Comparative Proteomics". Genome Res. 10 (5): 703–13. doi:10.1101/gr.10.5.703. PMC 310876. PMID 10810093.

[entrez-6] "Entrez Gene: LUC7L2 LUC7-like 2 (S. cerevisiae)".

[7] Alexis A Jourdain, Bridget E Begg, Eran Mick, Hardik Shah, Sarah E Calvo, Owen S Skinner, Rohit Sharma , Steven M Blue, Gene W Yeo, Christopher B Burge, Vamsi K Mootha (2021): Loss of LUC7L2 and U1 snRNP subunits shifts energy metabolism from glycolysis to OXPHOS. Mol Cell, 81(9):1905-1919.e12; pmid: 33852893; pmcid: pmc8314041 (available on 2022-05-06); doi: 10.1016/j.molcel.2021.02.033

[UniProt-8] "UniProt, Q9Y383" (jezik: engleski). Pristupljeno 26. 9. 2021.

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