LRG1

LRG1
Identifikatori
Aliasi	LRG1
Vanjski ID-jevi	OMIM: 611289 MGI: 1924155 HomoloGene: 36468 GeneCards: LRG1
Lokacija gena (čovjek)
Hrom.	Hromosom 19 (čovjek)
Kraj	4,540,036 bp
Lokacija gena (miš)
Hrom.	Hromosom 17 (miš)
Kraj	56,429,001 bp
Ontologija gena
Molekularna funkcija	• transforming growth factor beta receptor binding; • GO:0001948, GO:0016582 vezivanje za proteine; • molekularna funkcija;
Ćelijska komponenta	• Egzosom; • membrana; • Vanćelijsko; • specific granule lumen; • intracellular membrane-bounded organelle; • tertiary granule lumen; • ficolin-1-rich granule lumen; • extracellular region;
Biološki proces	• positive regulation of transforming growth factor beta receptor signaling pathway; • positive regulation of endothelial cell proliferation; • positive regulation of angiogenesis; • brown fat cell differentiation; • neutrophil degranulation; • GO:0022610 biološki proces; • response to bacterium;
	Izvori:Amigo / QuickGO
Ortolozi
	116844
	76905
	ENSG00000171236
	ENSMUSG00000037095
	P02750
	Q91XL1
	NM_052972
	NM_029796
	NP_443204
	NP_084072
	Wikipodaci
Pogledaj/uredi – čovjek	Pogledaj/uredi – miš

Leucinom bogati alfa-2-glikoprotein 1 je protein koji je kod ljudi kodiran genom LRG1.^[5]

Aminokiselinska sekvenca

Simboli

C: Cistein
D: Asparaginska kiselina
E: Glutaminska kiselina
F: Fenilalanin
G: Glicin
H: Histidin
I: Izoleucin
K: Lizin
L: Leucin
M: Metionin
N: Asparagin
P: Prolin
Q: Glutamin
R: Arginin
S: Serin
T: Treonin
V: Valin
W: Triptofan
Y: Tirozin

10	20	30	40	50
MSSWSRQRPK	SPGGIQPHVS	RTLFLLLLLA	ASAWGVTLSP	KDCQVFRSDH
GSSISCQPPA	EIPGYLPADT	VHLAVEFFNL	THLPANLLQG	ASKLQELHLS
SNGLESLSPE	FLRPVPQLRV	LDLTRNALTG	LPPGLFQASA	TLDTLVLKEN
QLEVLEVSWL	HGLKALGHLD	LSGNRLRKLP	PGLLANFTLL	RTLDLGENQL
ETLPPDLLRG	PLQLERLHLE	GNKLQVLGKD	LLLPQPDLRY	LFLNGNKLAR
VAAGAFQGLR	QLDMLDLSNN	SLASVPEGLW	ASLGQPNWDM	RDGFDISGNP
WICDQNLSDL	YRWLQAQKDK	MFSQNDTRCA	GPEAVKGQTL	LAVAKSQ

Funkcija

Pokazalo se da porodica leucinom bogatih proteina (LRR), uključujući LRG1, učestvuje u interakcijama protein-protein, transdukciji signala adheziji ćelija i razvoju. LRG1 se i+ekspzimirta tokom diferencijacije granulocita.^[5]^[6]

LRG1 je također uključen u promociju neovaskularizacije (rasta novih krvnih sudova), uzrokujući prebacivanje u transformiranju signala faktora rasta beta (TGFbeta) u endotelnim ćelijama. LRG1 se veže na akcesorni receptor endoglina i promovira signalizaciju putem ALK1 – Smad1 / 5/8.^[7]

Primjena

Razine LRG proteina su izrazito povišene u akutnoj upali slijepog crijeva i stoga se mogu koristiti kao dijagnostički pokazatelj.^[8]

LRG1 može biti potencijalni terapijski cilj za liječenje bolesti kod kojih postoji aberantna neovaskularizacija.^[7]

Reference

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000171236 - Ensembl, maj 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000037095 - Ensembl, maj 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ ^a ^b "Entrez Gene: LRG1 leucine-rich alpha-2-glycoprotein 1".
^ O'Donnell LC, Druhan LJ, Avalos BR (septembar 2002). "Molecular characterization and expression analysis of leucine-rich alpha2-glycoprotein, a novel marker of granulocytic differentiation". J. Leukoc. Biol. 72 (3): 478–85. PMID 12223515.
^ ^a ^b Wang X, Abraham S, McKenzie JA, Jeffs N, Swire M, Tripathi VB, Luhmann UF, Lange CA, Zhai Z, Arthur HM, Bainbridge JW, Moss SE, Greenwood J (juli 2013). "LRG1 promotes angiogenesis by modulating endothelial TGF-β signalling". Nature. 499 (7458): 306–11. doi:10.1038/nature12345. PMC 3836402. PMID 23868260.
^ Vargas IM (23. 6. 2009). "A urine test for appendicitis?". HarvardScience Press Release. Harvard College. Pristupljeno 25. 6. 2009.

Dopunska literatura

Li X, Miyajima M, Jiang C, Arai H (2007). "Expression of TGF-betas and TGF-beta type II receptor in cerebrospinal fluid of patients with idiopathic normal pressure hydrocephalus". Neurosci. Lett. 413 (2): 141–4. doi:10.1016/j.neulet.2006.11.039. PMID 17194537. S2CID 54324280.
Ramachandran P, Boontheung P, Xie Y, et al. (2006). "Identification of N-linked glycoproteins in human saliva by glycoprotein capture and mass spectrometry". J. Proteome Res. 5 (6): 1493–503. doi:10.1021/pr050492k. PMID 16740002.
Cummings C, Walder J, Treeful A, Jemmerson R (2006). "Serum leucine-rich alpha-2-glycoprotein-1 binds cytochrome c and inhibits antibody detection of this apoptotic marker in enzyme-linked immunosorbent assay". Apoptosis. 11 (7): 1121–9. doi:10.1007/s10495-006-8159-3. PMID 16699948. S2CID 39838086.
Liu T, Qian WJ, Gritsenko MA, et al. (2006). "Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry". J. Proteome Res. 4 (6): 2070–80. doi:10.1021/pr0502065. PMC 1850943. PMID 16335952.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Yamada S, Ohira M, Horie H, et al. (2004). "Expression profiling and differential screening between hepatoblastomas and the corresponding normal livers: identification of high expression of the PLK1 oncogene as a poor-prognostic indicator of hepatoblastomas". Oncogene. 23 (35): 5901–11. doi:10.1038/sj.onc.1207782. PMID 15221005.
Bunkenborg J, Pilch BJ, Podtelejnikov AV, Wiśniewski JR (2004). "Screening for N-glycosylated proteins by liquid chromatography mass spectrometry". Proteomics. 4 (2): 454–65. doi:10.1002/pmic.200300556. PMID 14760718.
Anderson NL, Polanski M, Pieper R, et al. (2004). "The human plasma proteome: a nonredundant list developed by combination of four separate sources". Mol. Cell. Proteomics. 3 (4): 311–26. doi:10.1074/mcp.M300127-MCP200. PMID 14718574.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
O'Donnell LC, Druhan LJ, Avalos BR (2002). "Molecular characterization and expression analysis of leucine-rich alpha2-glycoprotein, a novel marker of granulocytic differentiation". J. Leukoc. Biol. 72 (3): 478–85. PMID 12223515.
Saito K, Tanaka T, Kanda H, et al. (2002). "Gene expression profiling of mucosal addressin cell adhesion molecule-1+ high endothelial venule cells (HEV) and identification of a leucine-rich HEV glycoprotein as a HEV marker". J. Immunol. 168 (3): 1050–9. doi:10.4049/jimmunol.168.3.1050. PMID 11801638.
Takahashi N, Takahashi Y, Putnam FW (1985). "Periodicity of leucine and tandem repetition of a 24-amino acid segment in the primary structure of leucine-rich alpha 2-glycoprotein of human serum". Proc. Natl. Acad. Sci. U.S.A. 82 (7): 1906–10. doi:10.1073/pnas.82.7.1906. PMC 397442. PMID 3856868.
Andersen JD, Boylan KL, Xue FS, Anderson LB, Witthuhn BA, Higgins L, Skubitz AP (2010). "Identification of candidate biomarkers in ovarian cancer serum by depletion of highly abundant proteins and differential in-gel electrophoresis". Electrophoresis. 31 (4): 599–610. doi:10.1002/elps.200900441. PMC 3520508. PMID 20162585.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000171236 - Ensembl, maj 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000037095 - Ensembl, maj 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: LRG1 leucine-rich alpha-2-glycoprotein 1".

[pmid12223515-6] O'Donnell LC, Druhan LJ, Avalos BR (septembar 2002). "Molecular characterization and expression analysis of leucine-rich alpha2-glycoprotein, a novel marker of granulocytic differentiation". J. Leukoc. Biol. 72 (3): 478–85. PMID 12223515.

[pmid23868260-7] Wang X, Abraham S, McKenzie JA, Jeffs N, Swire M, Tripathi VB, Luhmann UF, Lange CA, Zhai Z, Arthur HM, Bainbridge JW, Moss SE, Greenwood J (juli 2013). "LRG1 promotes angiogenesis by modulating endothelial TGF-β signalling". Nature. 499 (7458): 306–11. doi:10.1038/nature12345. PMC 3836402. PMID 23868260.

[urlA_urine_test_for_appendicitis?_|_HarvardScience-8] Vargas IM (23. 6. 2009). "A urine test for appendicitis?". HarvardScience Press Release. Harvard College. Pristupljeno 25. 6. 2009.

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