Katepsin L1

CTSL
Dostupne strukture
PDB	Pretraga Human UniProta: PDBe RCSB
Spisak PDB ID kodova
	1CJL, 1CS8, 1ICF, 1MHW, 2NQD, 2VHS, 2XU1, 2XU3, 2XU4, 2XU5, 2YJ2, 2YJ8, 2YJ9, 2YJB, 2YJC, 3BC3, 3H89, 3H8B, 3H8C, 3HHA, 3HWN, 3IV2, 3K24, 3KSE, 3OF8, 3OF9, 4AXL, 4AXM, 5F02, 5I4H
Identifikatori
Aliasi	CTSL, CATL, CTSL1, MEP, katepsin L1
Vanjski ID-jevi	OMIM: 116880 HomoloGene: 129366 GeneCards: CTSL
Lokacija gena (čovjek)
Hrom.	Hromosom 9 (čovjek)
Kraj	87,731,469 bp
Obrazac RNK ekspresije
	Više referentnih podataka o ekspresiji
Ontologija gena
Molekularna funkcija	• fibronectin binding; • cysteine-type peptidase activity; • collagen binding; • GO:0031493 histone binding; • serpin family protein binding; • GO:0070122 peptidase activity; • GO:0001948, GO:0016582 vezivanje za proteine; • cysteine-type endopeptidase activity; • hydrolase activity; • proteoglycan binding; • serine-type endopeptidase activity;
Ćelijska komponenta	• extracellular region; • endolysosome lumen; • lysosomal lumen; • Lizozom; • Egzosom; • jedro; • Vanćelijsko; • collagen-containing extracellular matrix; • multivesicular body; • ćelijska membrana;
Biološki proces	• macrophage apoptotic process; • antigen processing and presentation; • adaptive immune response; • antigen processing and presentation of exogenous peptide antigen via MHC class II; • extracellular matrix disassembly; • Proteoliza; • toll-like receptor signaling pathway; • cellular response to thyroid hormone stimulus; • collagen catabolic process; • proteolysis involved in cellular protein catabolic process; • regulation of keratinocyte differentiation;
	Izvori:Amigo / QuickGO
Ortolozi
	1514
	n/a
	ENSG00000135047
	n/a
	P07711; Q9HBQ7
	n/a
NM_001257971; NM_001257972; NM_001257973; NM_001912; NM_145918;
	NM_001382757; NM_001382758; NM_001382766; NM_001382767; NM_001382768
	n/a
NP_001244900; NP_001244901; NP_001244902; NP_001903; NP_666023;
	NP_001369686; NP_001369687; NP_001369695; NP_001369696; NP_001369697; NP_001244902.1
	n/a
	Wikipodaci
Pogledaj/uredi – čovjek

Katepsin L1 je protein koji je kod čovjeka kodiran sa lokusa gena CTSL1.^[3]^[4]^[5]

Protein kodiran ovim genom je lizosomna cistein proteaza, koja ima glavnu ulogu u katabolizmu unutarćelijskih protein. Njegove podloge uključuju kolagen i elastin, kao i alfa-1 inhibitor proteaze, glavnog kontrolnog elementa aktivnosti neutrofilske elastaze. Kodirani protein je upleten u nekoliko patoloških procesa, uključujući i miofibrilnu nekrozu u miopatiji i ishemiji miokarda i odgovor na bubrežnu tubularnu proteinuriju.^[6]^[7]^[8]

Ovaj protein, koji je član peptidazne porodice C1, je dimer, sastavljen od disulfidno povezanih teških i lahkih lanaca, oba proizvedena iz jednog proteinskog prekursora. Najmanje dvije varijante ovog gena kodiraju transkripte istog protein.^[5]

Interakcije uredi

Pokazalo se da se CTSL1 ispoljava u proteinskoj interakciji sa cistatinom A.^[9]^[10]

Reference uredi

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000135047 - Ensembl, maj 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Chauhan SS, Popescu NC, Ray D, Fleischmann R, Gottesman MM, Troen BR (Feb 1993). "Cloning, genomic organization, and chromosomal localization of human cathepsin L". J Biol Chem. 268 (2): 1039–45. PMID 8419312.CS1 održavanje: više imena: authors list (link)
^ Joseph LJ, Chang LC, Stamenkovich D, Sukhatme VP (Jun 1988). "Complete nucleotide and deduced amino acid sequences of human and murine preprocathepsin L. An abundant transcript induced by transformation of fibroblasts". J Clin Invest. 81 (5): 1621–9. doi:10.1172/JCI113497. PMC 442598. PMID 2835398.CS1 održavanje: više imena: authors list (link)
^ ^a ^b "Entrez Gene: CTSL1 cathepsin L1".
^ Hadžiselimović R., Pojskić N. (2005): Uvod u humanu imunogenetiku. Institut za genetičko inženjerstvo i biotehnologiju (INGEB), Sarajevo, ISBN 9958-9344-3-4.
^ Mader S. S. (2000): Human biology. McGraw-Hill, New York, ISBN 0-07-290584-0; ISBN 0-07-117940-2.
^ Bajrović K, Jevrić-Čaušević A., Hadžiselimović R., Ed. (2005): Uvod u genetičko inženjerstvo i biotehnologiju. Institut za genetičko inženjerstvo i biotehnologiju (INGEB), Sarajevo, ISBN 9958-9344-1-8.
^ Majerle, Andreja; Jerala Roman (Sep 2003). "Protein inhibitors form complexes with procathepsin L and augment cleavage of the propeptide". Arch. Biochem. Biophys. United States. 417 (1): 53–8. doi:10.1016/S0003-9861(03)00319-9. ISSN 0003-9861. PMID 12921779. Referenca sadrži prazan nepoznati parametars: |laydate=, |laysummary=, i |laysource= (pomoć)CS1 održavanje: nepreporučeni parametar (link)
^ Estrada, S; Nycander M; Hill N J; Craven C J; Waltho J P; Björk I (maj 1998). "The role of Gly-4 of human cystatin A (stefin A) in the binding of target proteinases. Characterization by kinetic and equilibrium methods of the interactions of cystatin A Gly-4 mutants with papain, cathepsin B, and cathepsin L". Biochemistry. UNITED STATES. 37 (20): 7551–60. doi:10.1021/bi980026r. ISSN 0006-2960. PMID 9585570. Referenca sadrži prazan nepoznati parametars: |laydate=, |laysource=, i |laysummary= (pomoć)CS1 održavanje: nepreporučeni parametar (link)

Vanjski linkovi uredi

Commons ima datoteke na temu: Katepsin L1

MEROPS online database for peptidases and their inhibitors: C01.032^{[mrtav link]}

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000135047 - Ensembl, maj 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8419312-3] Chauhan SS, Popescu NC, Ray D, Fleischmann R, Gottesman MM, Troen BR (Feb 1993). "Cloning, genomic organization, and chromosomal localization of human cathepsin L". J Biol Chem. 268 (2): 1039–45. PMID 8419312.CS1 održavanje: više imena: authors list (link)

[pmid2835398-4] Joseph LJ, Chang LC, Stamenkovich D, Sukhatme VP (Jun 1988). "Complete nucleotide and deduced amino acid sequences of human and murine preprocathepsin L. An abundant transcript induced by transformation of fibroblasts". J Clin Invest. 81 (5): 1621–9. doi:10.1172/JCI113497. PMC 442598. PMID 2835398.CS1 održavanje: više imena: authors list (link)

[entrez-5] "Entrez Gene: CTSL1 cathepsin L1".

[6] Hadžiselimović R., Pojskić N. (2005): Uvod u humanu imunogenetiku. Institut za genetičko inženjerstvo i biotehnologiju (INGEB), Sarajevo, ISBN 9958-9344-3-4.

[7] Mader S. S. (2000): Human biology. McGraw-Hill, New York, ISBN 0-07-290584-0; ISBN 0-07-117940-2.

[8] Bajrović K, Jevrić-Čaušević A., Hadžiselimović R., Ed. (2005): Uvod u genetičko inženjerstvo i biotehnologiju. Institut za genetičko inženjerstvo i biotehnologiju (INGEB), Sarajevo, ISBN 9958-9344-1-8.

[pmid12921779-9] Majerle, Andreja; Jerala Roman (Sep 2003). "Protein inhibitors form complexes with procathepsin L and augment cleavage of the propeptide". Arch. Biochem. Biophys. United States. 417 (1): 53–8. doi:10.1016/S0003-9861(03)00319-9. ISSN 0003-9861. PMID 12921779. Referenca sadrži prazan nepoznati parametars: |laydate=, |laysummary=, i |laysource= (pomoć)CS1 održavanje: nepreporučeni parametar (link)

[pmid9585570-10] Estrada, S; Nycander M; Hill N J; Craven C J; Waltho J P; Björk I (maj 1998). "The role of Gly-4 of human cystatin A (stefin A) in the binding of target proteinases. Characterization by kinetic and equilibrium methods of the interactions of cystatin A Gly-4 mutants with papain, cathepsin B, and cathepsin L". Biochemistry. UNITED STATES. 37 (20): 7551–60. doi:10.1021/bi980026r. ISSN 0006-2960. PMID 9585570. Referenca sadrži prazan nepoznati parametars: |laydate=, |laysource=, i |laysummary= (pomoć)CS1 održavanje: nepreporučeni parametar (link)

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