KIF14

Kinezinoliki protein KIF14 jest protein koji je kod ljudi kodiran genom KIF14 sa hromosoma 1.

KIF14
Dostupne strukture PDB Pretraga ortologa: PDBe RCSB Spisak PDB ID kodova 4OZQ
Identifikatori
Aliasi	KIF14
Vanjski ID-jevi	OMIM: 611279 MGI: 1098226 HomoloGene: 8916 GeneCards: KIF14
Lokacija gena (čovjek) Hrom. Hromosom 1 (čovjek) Bend 1q32.1 Početak 200,551,497 bp Kraj 200,620,751 bp
Lokacija gena (miš) Hrom. Hromosom 1 (miš) Bend 1 E4|1 59.8 cM Početak 136,394,081 bp Kraj 136,459,249 bp
Obrazac RNK ekspresije Više referentnih podataka o ekspresiji
Ontologija gena Molekularna funkcija • vezivanje tubulina • nucleotide binding • protein kinase binding • plus-end-directed microtubule motor activity • PDZ domain binding • microtubule motor activity • microtubule binding • ATP binding • GO:0001948, GO:0016582 vezivanje za proteine • ATPase activity Ćelijska komponenta • Diobeno vreteno • citoplazma • Kinezin • jedro • membrana • midbody • Mikrotubula • ćelijska membrana • spindle midzone • citoskelet • citosol • Flemming body Biološki proces • negative regulation of integrin activation • cerebral cortex development • negative regulation of apoptotic process • SCF-dependent proteasomal ubiquitin-dependent protein catabolic process • regulation of neuron apoptotic process • hippocampus development • regulation of cell growth • Ćelijska dioba • substrate adhesion-dependent cell spreading • regulation of G1/S transition of mitotic cell cycle • cell proliferation in forebrain • regulation of G2/M transition of mitotic cell cycle • cerebellar granular layer structural organization • olfactory bulb development • microtubule depolymerization • proteasome-mediated ubiquitin-dependent protein catabolic process • cerebellar Purkinje cell layer structural organization • regulation of myelination • positive regulation of cell population proliferation • regulation of Rap protein signal transduction • cerebellar cortex development • positive regulation of cytokinesis • GO:1904089 negative regulation of neuron apoptotic process • establishment of protein localization • regulation of cell migration • mitotic metaphase plate congression • regulation of cell maturation • microtubule-based movement • activation of protein kinase activity • regulation of cell adhesion Izvori:Amigo / QuickGO
Ortolozi
Vrste	Čovjek	Miš
Entrez	9928	381293
Ensembl	ENSG00000118193	ENSMUSG00000041498
UniProt	Q15058	L0N7N1
RefSeq (mRNK)	NM_001305792 NM_014875	NM_001081258 NM_001287179
RefSeq (bjelančevina)	NP_001292721 NP_055690	NP_001274108
Lokacija (UCSC)	Chr 1: 200.55 – 200.62 Mb	Chr 1: 136.39 – 136.46 Mb
PubMed pretraga
Wikipodaci
Pogledaj/uredi – čovjek Pogledaj/uredi – miš

Aminokiselinska sekvenca

Dužina polipeptidnog lanca je 1.648 aminokiselina, a molekulska težina 186.492 Da..

• C: Cistein
• D: Asparaginska kiselina
• E: Glutaminska kiselina
• F: Fenilalanin
• G: Glicin
• H: Histidin
• I: Izoleucin
• K: Lizin
• L: Leucin
• M: Metionin
• N: Asparagin
• P: Prolin
• Q: Glutamin
• R: Arginin
• S: Serin
• T: Treonin
• V: Valin
• W: Triptofan
• Y: Tirozin

10		20		30		40		50
MSLHSTHNRN		NSGDILDIPS		SQNSSSLNAL		THSSRLKLHL		KSDMSECEND
DPLLRSAGKV		RDINRTYVIS		ASRKTADMPL		TPNPVGRLAL		QRRTTRNKES
SLLVSELEDT		TEKTAETRLT		LQRRAKTDSA		EKWKTAEIDS		VKMTLNVGGE
TENNGVSKES		RTNVRIVNNA		KNSFVASSVP		LDEDPQVIEM		MADKKYKETF
SAPSRANENV		ALKYSSNRPP		IASLSQTEVV		RSGHLTTKPT		QSKLDIKVLG
TGNLYHRSIG		KEIAKTSNKF		GSLEKRTPTK		CTTEHKLTTK		CSLPQLKSPA
PSILKNRMSN		LQVKQRPKSS		FLANKQERSA		ENTILPEEET		VVQNTSAGKD
PLKVENSQVT		VAVRVRPFTK		REKIEKASQV		VFMSGKEITV		EHPDTKQVYN
FIYDVSFWSF		DECHPHYASQ		TTVYEKLAAP		LLERAFEGFN		TCLFAYGQTG
SGKSYTMMGF		SEEPGIIPRF		CEDLFSQVAR		KQTQEVSYHI		EMSFFEVYNE
KIHDLLVCKD		ENGQRKQPLR		VREHPVYGPY		VEALSMNIVS		SYADIQSWLE
LGNKQRATAA		TGMNDKSSRS		HSVFTLVMTQ		TKTEFVEGEE		HDHRITSRIN
LIDLAGSERC		STAHTNGDRL		KEGVSINKSL		LTLGKVISAL		SEQANQRSVF
IPYRESVLTW		LLKESLGGNS		KTAMIATISP		AASNIEETLS		TLRYANQARL
IVNIAKVNED		MNAKLIRELK		AEIAKLKAAQ		RNSRNIDPER		YRLCRQEITS
LRMKLHQQER		DMAEMQRVWK		EKFEQAEKRK		LQETKELQKA		GIMFQMDNHL
PNLVNLNEDP		QLSEMLLYMI		KEGTTTVGKY		KPNSSHDIQL		SGVLIADDHC
TIKNFGGTVS		IIPVGEAKTY		VNGKHILEIT		VLRHGDRVIL		GGDHYFRFNH
PVEVQKGKRP		SGRDTPISEG		PKDFEFAKNE		LLMAQRSQLE		AEIKEAQLKA
KEEMMQGIQI		AKEMAQQELS		SQKAAYESKI		KALEAELREE		SQRKKMQEIN
NQKANHKIEE		LEKAKQHLEQ		EIYVNKKRLE		METLATKQAL		EDHSIRHARI
LEALETEKQK		IAKEVQILQQ		NRNNRDKTFT		VQTTWSSMKL		SMMIQEANAI
SSKLKTYYVF		GRHDISDKSS		SDTSIRVRNL		KLGISTFWSL		EKFESKLAAM
KELYESNGSN		RGEDAFCDPE		DEWEPDITDA		PVSSLSRRRS		RSLMKNRRIS
GCLHDIQVHP		IKNLHSSHSS		GLMDKSSTIY		SNSAESFLPG		ICKELIGSSL
DFFGQSYDEE		RTIADSLINS		FLKIYNGLFA		ISKAHEEQDE		ESQDNLFSSD
RAIQSLTIQT		ACAFEQLVVL		MKHWLSDLLP		CTNIARLEDE		LRQEVKKLGG
YLQLFLQGCC		LDISSMIKEA		QKNAIQIVQQ		AVKYVGQLAV		LKGSKLHFLE
NGNNKAASVQ		EEFMDAVCDG		VGLGMKILLD		SGLEKAKELQ		HELFRQCTKN
EVTKEMKTNA		MGLIRSLENI		FAESKIKSFR		RQVQEENFEY		QDFKRMVNRA
PEFLKLKHCL		EKAIEIIISA		LKGCHSDINL		LQTCVESIRN		LASDFYSDFS
VPSTSVGSYE		SRVTHIVHQE		LESLAKSLLF		CFESEESPDL		LKPWETYNQN
TKEEHQQSKS		SGIDGSKNKG		VPKRVYELHG		SSPAVSSEEC		TPSRIQWV

Dopunska literatura

• Nakagawa T, Tanaka Y, Matsuoka E, et al. (1997). "Identification and classification of 16 new kinesin superfamily (KIF) proteins in mouse genome". Proc. Natl. Acad. Sci. U.S.A. 94 (18): 9654–9. Bibcode:1997PNAS...94.9654N. doi:10.1073/pnas.94.18.9654. PMC 23244. PMID 9275178.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Corson TW, Huang A, Tsao MS, Gallie BL (2005). "KIF14 is a candidate oncogene in the 1q minimal region of genomic gain in multiple cancers". Oncogene. 24 (30): 4741–53. doi:10.1038/sj.onc.1208641. PMID 15897902.
• Gruneberg U, Neef R, Li X, et al. (2006). "KIF14 and citron kinase act together to promote efficient cytokinesis". J. Cell Biol. 172 (3): 363–72. doi:10.1083/jcb.200511061. PMC 2063646. PMID 16431929.
• Corson TW, Gallie BL (2006). "KIF14 mRNA expression is a predictor of grade and outcome in breast cancer". Int. J. Cancer. 119 (5): 1088–94. doi:10.1002/ijc.21954. PMID 16570270.
• Carleton M, Mao M, Biery M, et al. (2006). "RNA interference-mediated silencing of mitotic kinesin KIF14 disrupts cell cycle progression and induces cytokinesis failure". Mol. Cell. Biol. 26 (10): 3853–63. doi:10.1128/MCB.26.10.3853-3863.2006. PMC 1488988. PMID 16648480.
• Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.
• Bowles E, Corson TW, Bayani J, et al. (2007). "Profiling genomic copy number changes in retinoblastoma beyond loss of RB1". Genes Chromosomes Cancer. 46 (2): 118–29. doi:10.1002/gcc.20383. PMID 17099872. S2CID 22499766.
• Vasilescu J, Zweitzig DR, Denis NJ, et al. (2007). "The proteomic reactor facilitates the analysis of affinity-purified proteins by mass spectrometry: application for identifying ubiquitinated proteins in human cells". J. Proteome Res. 6 (1): 298–305. CiteSeerX 10.1.1.401.4220. doi:10.1021/pr060438j. PMID 17203973.
• Corson TW, Zhu CQ, Lau SK, et al. (2007). "KIF14 messenger RNA expression is independently prognostic for outcome in lung cancer". Clin. Cancer Res. 13 (11): 3229–34. doi:10.1158/1078-0432.CCR-07-0393. PMID 17545527.
• Madhavan J, Coral K, Mallikarjuna K, et al. (2007). "High expression of KIF14 in retinoblastoma: association with older age at diagnosis". Invest. Ophthalmol. Vis. Sci. 48 (11): 4901–6. doi:10.1167/iovs.07-0063. PMID 17962437.