Kinezinoliki protein KIF14 jest protein koji je kod ljudi kodiran genom KIF14 sa hromosoma 1.[5][6]

KIF14
Dostupne strukture
PDBPretraga ortologa: PDBe RCSB
Spisak PDB ID kodova

4OZQ

Identifikatori
AliasiKIF14
Vanjski ID-jeviOMIM: 611279 MGI: 1098226 HomoloGene: 8916 GeneCards: KIF14
Lokacija gena (čovjek)
Hromosom 1 (čovjek)
Hrom.Hromosom 1 (čovjek)[1]
Hromosom 1 (čovjek)
Genomska lokacija za KIF14
Genomska lokacija za KIF14
Bend1q32.1Početak200,551,497 bp[1]
Kraj200,620,751 bp[1]
Lokacija gena (miš)
Hromosom 1 (miš)
Hrom.Hromosom 1 (miš)[2]
Hromosom 1 (miš)
Genomska lokacija za KIF14
Genomska lokacija za KIF14
Bend1 E4|1 59.8 cMPočetak136,394,081 bp[2]
Kraj136,459,249 bp[2]
Obrazac RNK ekspresije
Više referentnih podataka o ekspresiji
Ontologija gena
Molekularna funkcija vezivanje tubulina
nucleotide binding
protein kinase binding
plus-end-directed microtubule motor activity
PDZ domain binding
microtubule motor activity
microtubule binding
ATP binding
GO:0001948, GO:0016582 vezivanje za proteine
ATPase activity
Ćelijska komponenta Diobeno vreteno
citoplazma
Kinezin
jedro
membrana
midbody
Mikrotubula
ćelijska membrana
spindle midzone
citoskelet
citosol
Flemming body
Biološki proces negative regulation of integrin activation
cerebral cortex development
negative regulation of apoptotic process
SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
regulation of neuron apoptotic process
hippocampus development
regulation of cell growth
Ćelijska dioba
substrate adhesion-dependent cell spreading
regulation of G1/S transition of mitotic cell cycle
cell proliferation in forebrain
regulation of G2/M transition of mitotic cell cycle
cerebellar granular layer structural organization
olfactory bulb development
microtubule depolymerization
proteasome-mediated ubiquitin-dependent protein catabolic process
cerebellar Purkinje cell layer structural organization
regulation of myelination
positive regulation of cell population proliferation
regulation of Rap protein signal transduction
cerebellar cortex development
positive regulation of cytokinesis
GO:1904089 negative regulation of neuron apoptotic process
establishment of protein localization
regulation of cell migration
mitotic metaphase plate congression
regulation of cell maturation
microtubule-based movement
activation of protein kinase activity
regulation of cell adhesion
Izvori:Amigo / QuickGO
Ortolozi
VrsteČovjekMiš
Entrez
Ensembl
UniProt
RefSeq (mRNK)

NM_001305792
NM_014875

NM_001081258
NM_001287179

RefSeq (bjelančevina)

NP_001292721
NP_055690

NP_001274108

Lokacija (UCSC)Chr 1: 200.55 – 200.62 MbChr 1: 136.39 – 136.46 Mb
PubMed pretraga[3][4]
Wikipodaci
Pogledaj/uredi – čovjekPogledaj/uredi – miš

Aminokiselinska sekvenca

uredi

Dužina polipeptidnog lanca je 1.648 aminokiselina, a molekulska težina 186.492 Da.[7].

1020304050
MSLHSTHNRNNSGDILDIPSSQNSSSLNALTHSSRLKLHLKSDMSECEND
DPLLRSAGKVRDINRTYVISASRKTADMPLTPNPVGRLALQRRTTRNKES
SLLVSELEDTTEKTAETRLTLQRRAKTDSAEKWKTAEIDSVKMTLNVGGE
TENNGVSKESRTNVRIVNNAKNSFVASSVPLDEDPQVIEMMADKKYKETF
SAPSRANENVALKYSSNRPPIASLSQTEVVRSGHLTTKPTQSKLDIKVLG
TGNLYHRSIGKEIAKTSNKFGSLEKRTPTKCTTEHKLTTKCSLPQLKSPA
PSILKNRMSNLQVKQRPKSSFLANKQERSAENTILPEEETVVQNTSAGKD
PLKVENSQVTVAVRVRPFTKREKIEKASQVVFMSGKEITVEHPDTKQVYN
FIYDVSFWSFDECHPHYASQTTVYEKLAAPLLERAFEGFNTCLFAYGQTG
SGKSYTMMGFSEEPGIIPRFCEDLFSQVARKQTQEVSYHIEMSFFEVYNE
KIHDLLVCKDENGQRKQPLRVREHPVYGPYVEALSMNIVSSYADIQSWLE
LGNKQRATAATGMNDKSSRSHSVFTLVMTQTKTEFVEGEEHDHRITSRIN
LIDLAGSERCSTAHTNGDRLKEGVSINKSLLTLGKVISALSEQANQRSVF
IPYRESVLTWLLKESLGGNSKTAMIATISPAASNIEETLSTLRYANQARL
IVNIAKVNEDMNAKLIRELKAEIAKLKAAQRNSRNIDPERYRLCRQEITS
LRMKLHQQERDMAEMQRVWKEKFEQAEKRKLQETKELQKAGIMFQMDNHL
PNLVNLNEDPQLSEMLLYMIKEGTTTVGKYKPNSSHDIQLSGVLIADDHC
TIKNFGGTVSIIPVGEAKTYVNGKHILEITVLRHGDRVILGGDHYFRFNH
PVEVQKGKRPSGRDTPISEGPKDFEFAKNELLMAQRSQLEAEIKEAQLKA
KEEMMQGIQIAKEMAQQELSSQKAAYESKIKALEAELREESQRKKMQEIN
NQKANHKIEELEKAKQHLEQEIYVNKKRLEMETLATKQALEDHSIRHARI
LEALETEKQKIAKEVQILQQNRNNRDKTFTVQTTWSSMKLSMMIQEANAI
SSKLKTYYVFGRHDISDKSSSDTSIRVRNLKLGISTFWSLEKFESKLAAM
KELYESNGSNRGEDAFCDPEDEWEPDITDAPVSSLSRRRSRSLMKNRRIS
GCLHDIQVHPIKNLHSSHSSGLMDKSSTIYSNSAESFLPGICKELIGSSL
DFFGQSYDEERTIADSLINSFLKIYNGLFAISKAHEEQDEESQDNLFSSD
RAIQSLTIQTACAFEQLVVLMKHWLSDLLPCTNIARLEDELRQEVKKLGG
YLQLFLQGCCLDISSMIKEAQKNAIQIVQQAVKYVGQLAVLKGSKLHFLE
NGNNKAASVQEEFMDAVCDGVGLGMKILLDSGLEKAKELQHELFRQCTKN
EVTKEMKTNAMGLIRSLENIFAESKIKSFRRQVQEENFEYQDFKRMVNRA
PEFLKLKHCLEKAIEIIISALKGCHSDINLLQTCVESIRNLASDFYSDFS
VPSTSVGSYESRVTHIVHQELESLAKSLLFCFESEESPDLLKPWETYNQN
TKEEHQQSKSSGIDGSKNKGVPKRVYELHGSSPAVSSEECTPSRIQWV

Reference

uredi
  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000118193 - Ensembl, maj 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000041498 - Ensembl, maj 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Nomura N, Nagase T, Miyajima N, Sazuka T, Tanaka A, Sato S, Seki N, Kawarabayasi Y, Ishikawa K, Tabata S (Dec 1995). "Prediction of the coding sequences of unidentified human genes. II. The coding sequences of 40 new genes (KIAA0041-KIAA0080) deduced by analysis of cDNA clones from human cell line KG-1". DNA Res. 1 (5): 223–9. doi:10.1093/dnares/1.5.223. PMID 7584044.
  6. ^ "Entrez Gene: KIF14 kinesin family member 14".
  7. ^ "UniProt, Q15058" (jezik: en.). Pristupljeno 13. 12. 2021.CS1 održavanje: nepoznati jezik (link)

Dopunska literatura

uredi