KDM7A

KDM7A
Dostupne strukture
PDB	Pretraga ortologa: PDBe RCSB
Spisak PDB ID kodova
	3KV5, 3KV6, 3KV9, 3KVA, 3KVB, 3U78
Identifikatori
Aliasi	KDM7A
Vanjski ID-jevi	MGI: 2443388 HomoloGene: 25281 GeneCards: KDM7A
Lokacija gena (čovjek)
Hrom.	Hromosom 7 (čovjek)
Kraj	140,176,983 bp
Lokacija gena (miš)
Hrom.	Hromosom 6 (miš)
Kraj	39,183,723 bp
Ontologija gena
Molekularna funkcija	• 2-oxoglutarate-dependent dioxygenase activity; • iron ion binding; • histone H3-methyl-lysine-9 demethylase activity; • histone H4-methyl-lysine-20 demethylase activity; • dioxygenase activity; • vezivanje iona metala; • methylated histone binding; • histone H3-methyl-lysine-36 demethylase activity; • oxidoreductase activity; • histone H3-tri/di-methyl-lysine-27 demethylase activity; • histone demethylase activity; • vezivanje iona cinka;
Ćelijska komponenta	• nukleoplazma; • Jedarce; • jedro;
Biološki proces	• GO:0009373 regulation of transcription, DNA-templated; • histone H3-K27 demethylation; • histone H3-K9 demethylation; • histone H4-K20 demethylation; • transcription, DNA-templated; • nervous system development; • GO:0060469, GO:0009371 positive regulation of transcription, DNA-templated; • histone H3-K36 demethylation; • midbrain development; • GO:0031497, GO:0006336, GO:0034724, GO:0001301, GO:0007580, GO:0034652, GO:0010847 chromatin organization;
	Izvori:Amigo / QuickGO
Ortolozi
	80853
	338523
	ENSG00000006459
	ENSMUSG00000042599
	Q6ZMT4
	Q3UWM4
	NM_030647
	NM_001033430
	NP_085150
	NP_001028602
	Wikipodaci
Pogledaj/uredi – čovjek	Pogledaj/uredi – miš

Lizin-demetilaza 7A je protein/enzim koji je kod ljudi kodiran genom KDM7A.^[5]

Aminokiselinska sekvenca

Dužina polipeptidnog lanca je 941 aminokiselina, а molekulska težina 106.557 Da.^[6]

C: Cistein

D: Asparaginska kiselina

E: Glutaminska kiselina

F: Fenilalanin

G: Glicin

H: Histidin

I: Izoleucin

K: Lizin

L: Leucin

M: Metionin

N: Asparagin

P: Prolin

Q: Glutamin

R: Arginin

S: Serin

T: Treonin

V: Valin

W: Triptofan

Y: Tirozin

10	20	30	40	50
MAGAAAAVAA	GAAAGAAAAA	VSVAAPGRAS	APPPPPPVYC	VCRQPYDVNR
FMIECDICKD	WFHGSCVGVE	EHHAVDIDLY	HCPNCAVLHG	SSLMKKRRNW
HRHDYTEIDD	GSKPVQAGTR	TFIKELRSRV	FPSADEIIIK	MHGSQLTQRY
LEKHGFDVPI	MVPKLDDLGL	RLPSPTFSVM	DVERYVGGDK	VIDVIDVARQ
ADSKMTLHNY	VKYFMNPNRP	KVLNVISLEF	SDTKMSELVE	VPDIAKKLSW
VENYWPDDSV	FPKPFVQKYC	LMGVQDSYTD	FHIDFGGTSV	WYHVLWGEKI
FYLIKPTDEN	LARYESWSSS	VTQSEVFFGD	KVDKCYKCVV	KQGHTLFVPT
GWIHAVLTSQ	DCMAFGGNFL	HNLNIGMQLR	CYEMEKRLKT	PDLFKFPFFE
AICWFVAKNL	LETLKELRED	GFQPQTYLVQ	GVKALHTALK	LWMKKELVSE
HAFEIPDNVR	PGHLIKELSK	VIRAIEEENG	KPVKSQGIPI	VCPVSRSSNE
ATSPYHSRRK	MRKLRDHNVR	TPSNLDILEL	HTREVLKRLE	MCPWEEDILS
SKLNGKFNKH	LQPSSTVPEW	RAKDNDLRLL	LTNGRIIKDE	RQPFADQSLY
TADSENEEDK	RRTKKAKMKI	EESSGVEGVE	HEESQKPLNG	FFTRVKSELR
SRSSGYSDIS	ESEDSGPECT	ALKSIFTTEE	SESSGDEKKQ	EITSNFKEES
NVMRNFLQKS	QKPSRSEIPI	KRECPTSTST	EEEAIQGMLS	MAGLHYSTCL
QRQIQSTDCS	GERNSLQDPS	SCHGSNHEVR	QLYRYDKPVE	CGYHVKTEDP
DLRTSSWIKQ	FDTSRFHPQD	LSRSQKCIRK	EGSSEISQRV	QSRNYVDSSG
SSLQNGKYMQ	NSNLTSGACQ	ISNGSLSPER	PVGETSFSVP	LHPTKRPASN
PPPISNQATK	GKRPKKGMAT	AKQRLGKILK	LNRNGHARFF	V

Reference

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000006459 - Ensembl, maj 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000042599 - Ensembl, maj 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: Lysine demethylase 7A". Pristupljeno 9. 4. 2016.
^ "UniProt, Q6ZMT4" (jezik: engleski). Pristupljeno 25. 9. 2021.

Dopunska literatura

Huang C, Xiang Y, Wang Y, Li X, Xu L, Zhu Z, Zhang T, Zhu Q, Zhang K, Jing N, Chen CD (2010). "Dual-specificity histone demethylase KIAA1718 (KDM7A) regulates neural differentiation through FGF4". Cell Res. 20 (2): 154–65. doi:10.1038/cr.2010.5. PMID 20084082.

Vanjski linkovi

PDBe-KB provides an overview of all the structure information available in the PDB for Human Lysine-specific demethylase 7A (KDM7A)

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000006459 - Ensembl, maj 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000042599 - Ensembl, maj 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: Lysine demethylase 7A". Pristupljeno 9. 4. 2016.

[UniProt-6] "UniProt, Q6ZMT4" (jezik: engleski). Pristupljeno 25. 9. 2021.

[5]

[1]

[2]

[3]

[4]

[6]