INTS3
Podjedinica 3 integratorskog kompleksa jest protein koji je kod ljudi kodiran genom INTS3 sa hromosoma 1.[5][6]
Aminokiselinska sekvenca
urediDužina polipeptidnog lanca je 1.043 aminokiseline, a molekulska težina 118. 070 Da.[7]
| 10 | 20 | 30 | 40 | 50 | ||||
|---|---|---|---|---|---|---|---|---|
| MELQKGKGAA | AAAAASGAAG | GGGGGAGAGA | PGGGRLLLST | SLDAKDELEE | ||||
| RLERCMSIVT | SMTAGVSERE | ANDALNAYVC | KGLPQHEEIC | LGLFTLILTE | ||||
| PAQAQKCYRD | LALVSRDGMN | IVLNKINQIL | MEKYLKLQDT | CRTQLVWLVR | ||||
| ELVKSGVLGA | DGVCMTFMKQ | IAGGGDVTAK | NIWLAESVLD | ILTEQREWVL | ||||
| KSSILIAMAV | YTYLRLIVDH | HGTAQLQALR | QKEVDFCISL | LRERFMECLM | ||||
| IGRDLVRLLQ | NVARIPEFEL | LWKDIIHNPQ | ALSPQFTGIL | QLLQSRTSRK | ||||
| FLACRLTPDM | ETKLLFMTSR | VRFGQQKRYQ | DWFQRQYLST | PDSQSLRCDL | ||||
| IRYICGVVHP | SNEVLSSDIL | PRWAIIGWLL | TTCTSNVAAS | NAKLALFYDW | ||||
| LFFSPDKDSI | MNIEPAILVM | HHSMKPHPAI | TATLLDFMCR | IIPNFYPPLE | ||||
| GHVRQGVFSS | LNHIVEKRVL | AHLAPLFDNP | KLDKELRAML | REKFPEFCSS | ||||
| PSPPVEVKIE | EPVSMEMDNH | MSDKDESCYD | NAEAAFSDDE | EDLNSKGKKR | ||||
| EFRFHPIKET | VVEEPVDITP | YLDQLDESLR | DKVLQLQKGS | DTEAQCEVMQ | ||||
| EIVDQVLEED | FDSEQLSVLA | SCLQELFKAH | FRGEVLPEEI | TEESLEESVG | ||||
| KPLYLIFRNL | CQMQEDNSSF | SLLLDLLSEL | YQKQPKIGYH | LLYYLRASKA | ||||
| AAGKMNLYES | FAQATQLGDL | HTCLMMDMKA | CQEDDVRLLC | HLTPSIYTEF | ||||
| PDETLRSGEL | LNMIVAVIDS | AQLQELVCHV | MMGNLVMFRK | DSVLNILIQS | ||||
| LDWETFEQYC | AWQLFLAHNI | PLETIIPILQ | HLKYKEHPEA | LSCLLLQLRR | ||||
| EKPSEEMVKM | VLSRPCHPDD | QFTTSILRHW | CMKHDELLAE | HIKSLLIKNN | ||||
| SLPRKRQSLR | SSSSKLAQLT | LEQILEHLDN | LRLNLTNTKQ | NFFSQTPILQ | ||||
| ALQHVQASCD | EAHKMKFSDL | FSLAEEYEDS | STKPPKSRRK | AALSSPRSRK | ||||
| NATQPPNAEE | ESGSSSASEE | EDTKPKPTKR | KRKGSSAVGS | DSD |
Reference
uredi- ^ a b c ENSG00000262826 GRCh38: Ensembl release 89: ENSG00000143624, ENSG00000262826 - Ensembl, maj 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000027933 - Ensembl, maj 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Baillat D, Hakimi MA, Naar AM, Shilatifard A, Cooch N, Shiekhattar R (Oct 2005). "Integrator, a multiprotein mediator of small nuclear RNA processing, associates with the C-terminal repeat of RNA polymerase II". Cell. 123 (2): 265–76. doi:10.1016/j.cell.2005.08.019. PMID 16239144. S2CID 18069461.
- ^ "Entrez Gene: INTS3 integrator complex subunit 3".
- ^ "UniProt, Q68E01" (jezik: en.). Pristupljeno 12. 12. 2021.CS1 održavanje: nepoznati jezik (link)
Dopunska literatura
uredi- Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
- Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
- Yu Y, Zhang C, Zhou G, et al. (2001). "Gene expression profiling in human fetal liver and identification of tissue- and developmental-stage-specific genes through compiled expression profiles and efficient cloning of full-length cDNAs". Genome Res. 11 (8): 1392–403. doi:10.1101/gr.175501. PMC 311073. PMID 11483580.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
- Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. Bibcode:2004PNAS..10112130B. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature. 441 (7091): 315–21. Bibcode:2006Natur.441..315G. doi:10.1038/nature04727. PMID 16710414.