ING3
Inhibitorni protein rasta 3 je protein koji je kod ljudi kodiran genom ING3.[5][6]
Aminokiselinska sekvenca uredi
Dužina polipeptidnog lanca je 418 aminokiselina, а molekulska težina 46.743 Da.[7]
| 10 | 20 | 30 | 40 | 50 | ||||
|---|---|---|---|---|---|---|---|---|
| MLYLEDYLEM | IEQLPMDLRD | RFTEMREMDL | QVQNAMDQLE | QRVSEFFMNA | ||||
| KKNKPEWREE | QMASIKKDYY | KALEDADEKV | QLANQIYDLV | DRHLRKLDQE | ||||
| LAKFKMELEA | DNAGITEILE | RRSLELDTPS | QPVNNHHAHS | HTPVEKRKYN | ||||
| PTSHHTTTDH | IPEKKFKSEA | LLSTLTSDAS | KENTLGCRNN | NSTASSNNAY | ||||
| NVNSSQPLGS | YNIGSLSSGT | GAGAITMAAA | QAVQATAQMK | EGRRTSSLKA | ||||
| SYEAFKNNDF | QLGKEFSMAR | ETVGYSSSSA | LMTTLTQNAS | SSAADSRSGR | ||||
| KSKNNNKSSS | QQSSSSSSSS | SLSSCSSSST | VVQEISQQTT | VVPESDSNSQ | ||||
| VDWTYDPNEP | RYCICNQVSY | GEMVGCDNQD | CPIEWFHYGC | VGLTEAPKGK | ||||
| WYCPQCTAAM | KRRGSRHK |
Funkcija uredi
Protein kodiran ovim genom sličan je ING1, proteinu supresoru tumora, koji može stupiti u interakciju s TP53, inhibirati rast ćelija i inducirati apoptozu. Ovaj protein sadrži PHD-prst, koji je čest motiv kod proteina uključenih u remodeliranje hromatina. Ovaj gen može aktivirati p53 transaktivirane promotore, uključujući promotore p21/waf1 i bax. Pokazalo se da prekomjerna ekspresija ovog gena inhibira rast ćelija i izaziva apoptozu. Gubitak alela i smanjena ekspresija ovog gena otkriveni su u karcinomu glave i vrata. Uočene su dvije alternativno prerađene varijante transkripta, koje kodiraju različite izoforme.[6]
Reference uredi
- ^ a b c GRCh38: Ensembl release 89: ENSG00000071243 - Ensembl, maj 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000029670 - Ensembl, maj 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Gunduz M, Ouchida M, Fukushima K, Ito S, Jitsumori Y, Nakashima T, Nagai N, Nishizaki K, Shimizu K (Jun 2002). "Allelic loss and reduced expression of the ING3, a candidate tumor suppressor gene at 7q31, in human head and neck cancers". Oncogene. 21 (28): 4462–70. doi:10.1038/sj.onc.1205540. PMID 12080476.
- ^ a b "Entrez Gene: ING3 inhibitor of growth family, member 3".
- ^ "UniProt, Q9NXR8" (jezik: engleski). Pristupljeno 25. 9. 2021.
Dopunska literatura uredi
- Doyon Y, Côté J (2004). "The highly conserved and multifunctional NuA4 HAT complex". Curr. Opin. Genet. Dev. 14 (2): 147–54. doi:10.1016/j.gde.2004.02.009. PMID 15196461.
- Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
- Sanger Centre, The; Washington University Genome Sequencing Cente, The (1999). "Toward a complete human genome sequence". Genome Res. 8 (11): 1097–108. doi:10.1101/gr.8.11.1097. PMID 9847074.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Nagashima M, Shiseki M, Pedeux RM, et al. (2003). "A novel PHD-finger motif protein, p47ING3, modulates p53-mediated transcription, cell cycle control, and apoptosis". Oncogene. 22 (3): 343–50. doi:10.1038/sj.onc.1206115. PMID 12545155.
- Hillier LW, Fulton RS, Fulton LA, et al. (2003). "The DNA sequence of human chromosome 7". Nature. 424 (6945): 157–64. Bibcode:2003Natur.424..157H. doi:10.1038/nature01782. PMID 12853948.
- Cai Y, Jin J, Tomomori-Sato C, et al. (2003). "Identification of new subunits of the multiprotein mammalian TRRAP/TIP60-containing histone acetyltransferase complex". J. Biol. Chem. 278 (44): 42733–6. doi:10.1074/jbc.C300389200. PMID 12963728.
- Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
- Doyon Y, Selleck W, Lane WS, et al. (2004). "Structural and functional conservation of the NuA4 histone acetyltransferase complex from yeast to humans". Mol. Cell. Biol. 24 (5): 1884–96. doi:10.1128/MCB.24.5.1884-1896.2004. PMC 350560. PMID 14966270.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Cai Y, Jin J, Florens L, et al. (2005). "The mammalian YL1 protein is a shared subunit of the TRRAP/TIP60 histone acetyltransferase and SRCAP complexes". J. Biol. Chem. 280 (14): 13665–70. doi:10.1074/jbc.M500001200. PMID 15647280.
- Wang Y, Dai DL, Martinka M, Li G (2007). "Prognostic significance of nuclear ING3 expression in human cutaneous melanoma". Clin. Cancer Res. 13 (14): 4111–6. doi:10.1158/1078-0432.CCR-07-0408. PMID 17634537.