IL22RA1
Interleukinski receptor 22 alfa 1 jest protein koji je kod ljudi kodiran genom IL22RA1 sa hromosoma 1.[5]
Aminokiselinska sekvenca uredi
Dužina polipeptidnog lanca je 574 aminokiseline, a molekulska težina 63.077 Da.[6]
| 10 | 20 | 30 | 40 | 50 | ||||
|---|---|---|---|---|---|---|---|---|
| MRTLLTILTV | GSLAAHAPED | PSDLLQHVKF | QSSNFENILT | WDSGPEGTPD | ||||
| TVYSIEYKTY | GERDWVAKKG | CQRITRKSCN | LTVETGNLTE | LYYARVTAVS | ||||
| AGGRSATKMT | DRFSSLQHTT | LKPPDVTCIS | KVRSIQMIVH | PTPTPIRAGD | ||||
| GHRLTLEDIF | HDLFYHLELQ | VNRTYQMHLG | GKQREYEFFG | LTPDTEFLGT | ||||
| IMICVPTWAK | ESAPYMCRVK | TLPDRTWTYS | FSGAFLFSMG | FLVAVLCYLS | ||||
| YRYVTKPPAP | PNSLNVQRVL | TFQPLRFIQE | HVLIPVFDLS | GPSSLAQPVQ | ||||
| YSQIRVSGPR | EPAGAPQRHS | LSEITYLGQP | DISILQPSNV | PPPQILSPLS | ||||
| YAPNAAPEVG | PPSYAPQVTP | EAQFPFYAPQ | AISKVQPSSY | APQATPDSWP | ||||
| PSYGVCMEGS | GKDSPTGTLS | SPKHLRPKGQ | LQKEPPAGSC | MLGGLSLQEV | ||||
| TSLAMEESQE | AKSLHQPLGI | CTDRTSDPNV | LHSGEEGTPQ | YLKGQLPLLS | ||||
| SVQIEGHPMS | LPLQPPSRPC | SPSDQGPSPW | GLLESLVCPK | DEAKSPAPET | ||||
| SDLEQPTELD | SLFRGLALTV | QWES |
Funkcija uredi
Protein kodiran ovim genom pripada porodici II citokinskih receptora i pokazalo se da je receptor za interleukin 22 (IL22). IL22 receptor je proteinski kompleks koji se sastoji od ovog proteina i receptora interleukina 10 beta (IL10RB/CRFB4), podjedinice koju također dijeli kompleks receptora za interleukin 10 (IL10). Ovaj gen i receptor interleukina 28 alfa (IL28RA) formiraju klaster gena receptora citokina u hromosomskoj regiji 1p36.
Reference uredi
- ^ a b c GRCh38: Ensembl release 89: ENSG00000142677 - Ensembl, maj 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000037157 - Ensembl, maj 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Entrez Gene: Interleukin 22 receptor, alpha 1".
- ^ "UniProt, Q8N6P7" (jezik: eng.). Pristupljeno 29. 11. 2021.CS1 održavanje: nepoznati jezik (link)
Dopunska literatura uredi
- Bleicher L, de Moura PR, Watanabe L, Colau D, Dumoutier L, Renauld JC, Polikarpov I (septembar 2008). "Crystal structure of the IL-22/IL-22R1 complex and its implications for the IL-22 signaling mechanism". FEBS Letters. 582 (20): 2985–92. doi:10.1016/j.febslet.2008.07.046. PMID 18675809. S2CID 20952148.
- Jones BC, Logsdon NJ, Walter MR (septembar 2008). "Structure of IL-22 bound to its high-affinity IL-22R1 chain". Structure. 16 (9): 1333–44. doi:10.1016/j.str.2008.06.005. PMC 2637415. PMID 18599299.
- de Moura PR, Watanabe L, Bleicher L, Colau D, Dumoutier L, Lemaire MM, Renauld JC, Polikarpov I (april 2009). "Crystal structure of a soluble decoy receptor IL-22BP bound to interleukin-22". FEBS Letters. 583 (7): 1072–7. doi:10.1016/j.febslet.2009.03.006. PMID 19285080.
- Dumoutier L, de Meester C, Tavernier J, Renauld JC (septembar 2009). "New activation modus of STAT3: a tyrosine-less region of the interleukin-22 receptor recruits STAT3 by interacting with its coiled-coil domain". The Journal of Biological Chemistry. 284 (39): 26377–84. doi:10.1074/jbc.M109.007955. PMC 2785325. PMID 19632985.
- Wu PW, Li J, Kodangattil SR, Luxenberg DP, Bennett F, Martino M, Collins M, Dunussi-Joannopoulos K, Gill DS, Wolfman NM, Fouser LA (oktobar 2008). "IL-22R, IL-10R2, and IL-22BP binding sites are topologically juxtaposed on adjacent and overlapping surfaces of IL-22". Journal of Molecular Biology. 382 (5): 1168–83. doi:10.1016/j.jmb.2008.07.046. PMID 18675824.
- Meng S, Gui Q, Xu Q, Lu K, Jiao X, Fan J, Ge B, Ke Y, Zhang S, Wu J, Wang C (august 2010). "Association of Shp2 with phosphorylated IL-22R1 is required for interleukin-22-induced MAP kinase activation". Journal of Molecular Cell Biology. 2 (4): 223–30. doi:10.1093/jmcb/mjq017. PMC 2948820. PMID 20671117.
- Kotenko SV, Izotova LS, Mirochnitchenko OV, Esterova E, Dickensheets H, Donnelly RP, Pestka S (januar 2001). "Identification of the functional interleukin-22 (IL-22) receptor complex: the IL-10R2 chain (IL-10Rbeta ) is a common chain of both the IL-10 and IL-22 (IL-10-related T cell-derived inducible factor, IL-TIF) receptor complexes". The Journal of Biological Chemistry. 276 (4): 2725–32. doi:10.1074/jbc.M007837200. PMID 11035029.
- Chang Y, Al-Alwan L, Risse PA, Halayko AJ, Martin JG, Baglole CJ, Eidelman DH, Hamid Q (decembar 2012). "Th17-associated cytokines promote human airway smooth muscle cell proliferation". FASEB Journal. 26 (12): 5152–60. doi:10.1096/fj.12-208033. PMID 22898922. S2CID 205369384.
- Shioya M, Andoh A, Kakinoki S, Nishida A, Fujiyama Y (mart 2008). "Interleukin 22 receptor 1 expression in pancreas islets". Pancreas. 36 (2): 197–9. doi:10.1097/MPA.0b013e3181594258. PMID 18376313. S2CID 26713011.
Vanjski linkovi uredi
Ovaj članak uključuje tekst iz Nacionalne medicinske biblioteke Sjedinjenih Država, koji je u javnom vlasništvu.